Core Viewpoint - The article highlights the increasing concern regarding the consumption of sugary drinks and their association with colorectal cancer (CRC), particularly among younger populations, emphasizing the need for further research on the impact of these beverages on cancer progression and metastasis [2][6]. Group 1: Sugary Drinks and Colorectal Cancer - Sugary drinks, defined as liquids containing added sugars like sucrose and high-fructose corn syrup, have seen a global increase in consumption since the 1980s, correlating with rising rates of obesity, diabetes, and fatty liver disease [2]. - The consumption of sugary drinks has been linked to a doubling of the risk of developing colorectal cancer in younger individuals, as confirmed by large-scale epidemiological studies [6]. Group 2: Research Findings - A recent study published in Nature Metabolism reveals that fructose and glucose from sugary drinks enhance colorectal cancer metastasis through the activation of sorbitol dehydrogenase (SORD) [3][9]. - The research indicates that a combination of glucose and fructose significantly increases the migration and metastatic potential of colorectal cancer cells compared to glucose alone, suggesting a specific mechanism involving the NAD⁺/NADH ratio and glycolytic activity [7]. Group 3: Implications for Treatment and Diet - The findings of this research underscore the harmful effects of sugary drinks on the progression of colorectal cancer and suggest potential dietary interventions and treatment strategies to inhibit metastasis in patients [9].