Core Viewpoint - Ovarian aging significantly impacts women's overall health and vitality, leading to a decline in various physiological functions, and modern medicine proposes endogenous anti-aging strategies using placental peptides to rejuvenate ovarian function and extend the healthy lifespan of women [1][2][4]. Group 1: Ovarian Function and Aging - The ovaries are central to women's physiological systems, regulating reproductive cycles and maintaining hormonal balance, which is crucial for bone strength, cardiovascular health, and skin metabolism [1]. - Ovarian function decline initiates a domino effect, affecting endocrine, immune, and other bodily systems, thereby impacting overall youthfulness [1][2]. - The aging of the ovaries is closely linked to cellular aging and immune system decline, creating a vicious cycle of inflammation and cellular interaction [2][4]. Group 2: Mechanisms of Ovarian Aging - Cellular senescence is characterized by irreversible cell cycle arrest, leading to changes in morphology, metabolism, and gene expression, with senescent cells secreting SASP factors that induce chronic inflammation [4]. - The accumulation of senescent cells in ovarian stroma secretes substances like CCL5, causing granulosa cell apoptosis and follicular abnormalities [4]. - The inflammatory microenvironment associated with ovarian aging is marked by NLRP3 inflammasome activation and increased pro-inflammatory cytokines, resulting in fibrosis, reduced follicle count, and poor oocyte quality [4]. Group 3: Intervention Strategies - Traditional anti-aging methods are insufficient as they do not address the root causes of ovarian aging, while emerging biological interventions like placental peptides offer targeted cellular rejuvenation [4][5]. - Placental peptides, derived from human placenta, contain over 400 active cell factors, demonstrating high biocompatibility, safety, and rapid systemic effects, with nearly 100% bioavailability [5]. - Clinical data indicate that the use of placental peptides leads to significant reductions in follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels, while increasing estradiol (E2) levels and improving symptoms related to reproductive aging [5].