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湿疹药物试验数据令人失望 赛诺菲股价暴跌9%
Core Viewpoint - Sanofi's stock price dropped by 9% due to unsatisfactory late-stage trial data for its eczema treatment drug, amlitelimab, which failed to meet analyst expectations [1] Group 1: Drug Performance - Sanofi claims that amlitelimab achieved its primary goals, showing better skin clearance rates and disease severity compared to placebo [1] - Analysts believe the results are weaker than earlier trials and less effective compared to competitors' biologics [1] - JPMorgan noted that amlitelimab's efficacy is inferior to Sanofi's existing blockbuster drug, Dupixent, which treats the same skin condition and is set to lose patent protection in 2031 [1] Group 2: Analyst Expectations - TD Cowen analysts previously expected amlitelimab to achieve an EASI-75 rate of 45% to 50% within 24 weeks, while actual data showed an EASI-75 rate of 35.9% to 46.0% [1] Group 3: Future Potential - Sanofi executives stated that amlitelimab has the potential for administration only four times a year and could make significant advancements in treating atopic dermatitis [1] - The drug is anticipated to complement or replace Dupixent before its patent expiration, with peak sales projected to exceed $5 billion [1]