Core Insights - A recent study led by Professor Wang Jian'an's team compared the clinical outcomes of coronary angiography-derived fractional flow reserve (FFR) guided intervention strategies with intravascular ultrasound (IVUS) guided strategies in patients with coronary artery disease (CAD) [1][2] - The study found that in non-complex CAD patients, the angiography-derived FFR guided intervention strategy is not inferior to the IVUS guided strategy in clinical outcomes and has the advantage of reducing stent implantation [1] Group 1 - Coronary artery disease is a major global health threat caused by narrowing or blockage of coronary arteries, leading to myocardial ischemia and related conditions [1] - Fractional flow reserve is a critical functional indicator for assessing coronary blood flow, essential for developing appropriate treatment strategies in CAD interventions [1] Group 2 - Traditional invasive FFR is widely recognized but is complex and carries certain risks, while IVUS provides direct visualization of vascular structures but is also an invasive procedure [2] - The emergence of imaging-derived FFR technology offers a non-invasive alternative that simplifies the procedure, requiring only angiography without additional guidewires or vasodilators [2] - The study provides a simpler decision-making and optimization tool for percutaneous coronary intervention, contributing strong evidence for future updates to cardiovascular intervention guidelines [2]