Eisai's Strengths in Orexin Platform Highlight of E2086 Oral Presentation at World Sleep 2025 September 11, 2025 Eisai Co., Ltd. Katsutoshi Ido, Ph.D. Chief Scientific Officer Orexin: A Key Regulator of Sleep-Wakefulness Orexin receptor antagonist Dayvigo Orexin Sleep Center Arousal Center Suppression Dayvigo Suppressing excessive orexin signaling at night Inhibition Sleep Orexin receptor agonist E2086 2 Sleep Center Arousal Center Orexin Suppression E2086 Enhancement of daytime orexin signaling Enhancement ...