Maravai LifeSciences (NasdaqGS:MRVI) Q4 2025 Earnings call February 25, 2026 05:00 PM ET Company ParticipantsBernd Brust - CEOChanfeng Zhao - SVP and Chief Scientific OfficerDebra Hart - Head of Investor RelationsDoug Schenkel - Managing DirectorRajesh Asarpota - EVP and CFOConference Call ParticipantsJosh Heinen - Research AnalystJustin Bowers - Equity Research AnalystMatt Hewitt - Senior Research AnalystMatt Larew - Research AnalystMatt Stanton - VP and Equity Research AnalystMatthew Parisi - Research Ana ...

Maravai LifeSciences (NasdaqGS:MRVI) Q4 2025 Earnings call February 25, 2026 05:00 PM ET Speaker8Ladies and gentlemen, thank you for your continued patience. Your meeting will begin shortly. If you need assistance at any time today, please press star 0 and a member of our team will be happy to help you. Again, ladies and gentlemen, thank you for your continued patience. Your meeting will begin shortly. Again, if you do need assistance at any time today, please press star 0 and a member of our team will be h ...

Schrödinger (NasdaqGS:SDGR) Q4 2025 Earnings call February 25, 2026 04:30 PM ET Company ParticipantsConor MacKay - Equity Research AssociateJaren Madden - Chief Corporate Affairs Officer and Head of Investor RelationsKaren Akinsanya - President, Head of Therapeutics R&D, and Partnerships Chief Strategy OfficerRamy Farid - CEORichie Jain - CFONone - Company RepresentativeNone - Company RepresentativeNone - Company RepresentativeNone - Company RepresentativeConference Call ParticipantsBrendan Smith - Director ...

Core Insights - Recursion has reached a pivotal moment, transitioning from demonstrating AI's role in drug discovery to showcasing an AI-native operating system that can generate clinical proof and sustainable value [3] - The company enters 2026 with five clinical programs advancing and over $500 million in milestone payments earned to date, reflecting a robust pipeline and disciplined execution strategy [3][6] Business Highlights - Recursion's pipeline is diversified, powered by its AI-native Recursion OS, with both wholly-owned and partnered programs [4] - The company achieved its first clinical validation of the Recursion OS in Familial Adenomatous Polyposis (FAP), with 75% of evaluable patients showing reductions in total polyp burden [6][9] - Recursion has received $134 million in milestone payments from its collaboration with Sanofi, with five discovery program packages accepted to date [6][14] Financial Performance - Total revenue for Q4 2025 was $35.5 million, a significant increase from $4.5 million in Q4 2024, driven by milestone payments and collaboration agreements [15] - Research and development expenses for Q4 2025 were $95.9 million, slightly lower than $98.3 million in Q4 2024, while total R&D expenses for the year were $475.3 million compared to $314.4 million in 2024 [15][22] - The net loss for Q4 2025 was $108.1 million, an improvement from a net loss of $178.9 million in Q4 2024, with a total net loss of $644.8 million for the year [15][22] Pipeline and Milestones - Recursion's pipeline includes several promising candidates, such as REC-4881 for FAP, REC-617 for advanced solid tumors, and REC-7735 for PI3Kα H1047R mutation [7][9] - Upcoming milestones include FDA engagement for REC-4881 and additional Phase 1/2 clinical data expected in 2026 [9][12] - The company anticipates further advancements in its partnered discovery programs, with potential for additional near-term milestones as programs progress [8][14] Cash Position - As of December 31, 2025, Recursion had cash and cash equivalents of $754 million, providing a runway into early 2028 without additional financing [6][15] - The company achieved a cash operating expense of approximately $399.2 million for 2025, reflecting improved operational efficiency [12][22]

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Financial Data and Key Metrics Changes - In Q4 2025, the company generated revenue of $772 million, resulting in 4% organic growth, with a full-year revenue of $2.86 billion, reflecting 3% organic growth [22][24] - Adjusted EPS for Q4 was $1.70, exceeding the high end of expectations, while full-year adjusted EPS was $5.06, representing 3% growth year-over-year [10][24] - Adjusted operating margins for Q4 were 29.7%, down 60 basis points year-over-year, and for the full year, they were 27.1%, down 120 basis points year-over-year [23][24] Business Line Data and Key Metrics Changes - The diagnostics segment saw revenue of $390 million in Q4, up 10% reported and 7% organic, while the life sciences segment generated $382 million, flat on an organic basis [26][28] - For the full year, diagnostics grew 4% organically, while life sciences grew 2% organically [26][27] - The Signals software business was flat year-over-year organically in Q4 but grew in the high teens organically for the full year [27] Market Data and Key Metrics Changes - Geographically, the company experienced flat performance in both the Americas and APAC, with double-digit growth in Europe [26] - For the full year, the Americas grew low single digits, Europe grew high single digits, and APAC declined in the low single digits [26] Company Strategy and Development Direction - The company plans to continue capital deployment through share repurchases and acquisitions, having repurchased over $800 million worth of shares in 2025 [10][11] - The acquisition of ACD/Labs is expected to contribute over $20 million in revenue in 2026, adding approximately 75 basis points to overall revenue growth [12][13] - The introduction of the AI models-as-a-service platform, Signals Xynthetica, is aimed at enhancing drug development processes [15][16] Management's Comments on Operating Environment and Future Outlook - Management expressed cautious optimism regarding the recovery of end markets, reiterating a 2%-3% organic growth outlook for 2026 [12][31] - The company noted potential upside from improved customer sentiment in pharma and biotech, as well as ongoing cost efficiency initiatives [20][22] - Management highlighted the importance of maintaining a disciplined approach to capital deployment while navigating a fluid market environment [11][20] Other Important Information - The company generated free cash flow of $162 million in Q4, resulting in 84% conversion of adjusted net income, with a full-year free cash flow of $515 million [25] - The net debt to adjusted EBITDA leverage ratio was 2.7x, with 100% of debt being fixed rate [25] Q&A Session Summary Question: Can you provide more color on the 2%-3% organic growth framework and potential upside? - Management acknowledged positive signs in end markets since September and identified multiple paths for potential upside in both revenue and EPS [39][40] Question: What is the outlook for life sciences versus diagnostics relative to the 2%-3% growth? - Management indicated that life sciences is expected to grow at low single digits, while diagnostics is also expected to grow at low single digits, with specific growth rates for sub-segments [55] Question: How is the company approaching M&A opportunities? - Management stated that any potential M&A must provide a strong strategic addition and that they have not yet identified compelling targets [58] Question: Can you elaborate on the performance within pharma biotech and order trends? - Management noted cautious optimism and consistency in order trends, with no budget flush observed but improved clarity in the policy environment [60][61] Question: What are the expectations for the diagnostics business going into 2026? - Management expressed that diagnostics could provide upside, particularly in newborn screening and immunodiagnostics, despite taking a more prudent approach to assumptions [63][64]

Core Insights - The healthcare sector is optimistic about 2026, with expectations of better performance compared to previous years due to settled drug pricing issues, falling interest rates, and promising scientific advancements [3] Company Updates - Novo Nordisk plans to expand its incretin market with the introduction of the Wegovy oral pill and its injectable version in 2026, despite anticipating price pressures due to a recent drug pricing deal with the Trump administration and the introduction of cheaper generics [5][6] - Bristol Myers Squibb aims to deliver up to 10 new products by the end of the decade to offset losses from upcoming exclusivity expirations of blockbuster drugs, with a diverse portfolio in late-stage development [7][8] - Pfizer is heavily invested in obesity treatments following its $10 billion acquisition of Metsera, planning to launch 10 late-stage studies of obesity products by the end of the year [11][12] Business Development Strategies - Novo Nordisk is focusing on volume growth to counteract price cuts and is actively seeking complementary assets to enhance its pipeline [6] - Bristol Myers Squibb is casting a wide net for business development, aiming to build on its core therapeutic areas and pursue innovative science for challenging diseases [10] Collaborations and Investments - Eli Lilly and Nvidia announced a joint investment of up to $1 billion over five years to create a lab in San Francisco for AI-driven drug discovery [14] - AbbVie has reached an agreement with the Trump administration to lower drug prices and invest $100 billion domestically over the next decade, while also licensing an experimental cancer therapy from RemeGen for $650 million upfront, potentially worth $5.6 billion [14]

Company Overview - Nxera Pharma is not a traditional Japanese pharmaceutical company, focusing on structure-based drug discovery against GPCRs using the NxWave platform [2] - The company has delivered 30 drug candidates over the past 12 years, leveraging proprietary data assets, structural biology, and AI advancements [2] Business Model and Operations - Nxera Pharma has established a lean development and commercial business modeled on the U.S. go-to-market strategy, with bilingual teams guiding approval and launch processes [3] - The company is focused on delivering specialty and rare disease medicines to patients with unmet needs in Japan [3] Clinical and Commercial Progress - Nxera Pharma has 15 clinical programs being advanced by partners across multiple therapeutic areas, indicating strong productivity from its drug discovery platform [4] - The company has two marketed medicines, PIVLAZ and QUVIVIQ, which continue to grow and positively impact patients [4]

Summary of Novartis Conference Call Company Overview - **Company**: Novartis - **Event**: 44th J.P. Morgan Healthcare Conference - **CEO**: Vasant Narasimhan Key Points Financial Performance - Novartis achieved a **7%** increase in sales and a **15%** increase in core operating income over recent years [2] - The core operating margin is projected to reach **38.7%** by 2024, with a target of **40%** [2][3] - Free cash flow generation was **$16 billion** last year and is on track for the same in 2025 [3] - Return on invested capital has improved to **17%**, positioning Novartis in the top quartile among peers [3] Strategic Focus - The company has transitioned to a pure-play medicines company, focusing on high-end technologies in four core therapeutic areas [2][4] - Capital allocation priorities include organic business investment, value-creating bolt-ons, and ongoing share buybacks, with a **$15 billion** share buyback program initiated [5] - Novartis aims to consistently grow dividends in Swiss francs [5] Pipeline and Growth Opportunities - Novartis has **14 in-market blockbusters** and **nine brands** with multi-billion-dollar peak sales potential [6] - The company is entering a catalyst-rich period with **15 submission-enabling readouts** expected in the next two years [6][14] - Significant market opportunities identified in RNA therapeutics (**$36 billion**), radioligand therapies (**$28 billion**), and cell and gene therapies (up to **$50 billion**) [7] Long-term Guidance - Novartis projects **high single-digit growth** for 2024-2025, **5%-6% growth** through 2030, and **mid-single-digit growth** beyond 2030 [8] - The company aims to grow revenues to **$60 billion** to **$80 billion** by the middle of the next decade [9] Commercial Execution - Strong commercial execution noted in the U.S. and international markets, with significant market shares achieved for products like Cosentyx and Kisqali [11][12] - Novartis is ranked **number two in China**, **number one in Germany**, and **number four in Japan** [12] Product Launches and Approvals - Kisqali is projected to exceed **$10 billion** in peak sales, while Scemblix is expected to reach over **$4 billion** [13] - The launch of Roxido is a top priority, with expectations for it to become a multi-billion-dollar medicine [13] - Remibrutinib is highlighted as a key asset with potential in multiple indications, including food allergies and hidradenitis [21] Oncology and R&D Strategy - Novartis is focusing on expanding its oncology pipeline, with a strong emphasis on radioligand therapies and small molecules [27][46] - The company has appointed a new oncology R&D chief to strengthen its leadership in this area [50] ESG and Global Health Initiatives - Novartis emphasizes its commitment to ESG and global health, with notable achievements in malaria treatment [30] Market Challenges and Considerations - The company anticipates **1%-2% margin dilution** from the acquisition of Avidity and the impact of recent healthcare reforms [10][66] - Guidance includes considerations for potential pricing impacts from the Inflation Reduction Act [66] Conclusion - Novartis is positioned for continued growth with a robust pipeline, strong financial performance, and a commitment to shareholder value through strategic investments and acquisitions [31]

Core Insights - SandboxAQ and MapLight Therapeutics have entered a strategic collaboration to develop therapies targeting a novel G protein-coupled receptor (GPCR) for central nervous system (CNS) disorders [1][2] Financial Terms - SandboxAQ received an upfront payment and is eligible for additional milestone payments totaling up to $200 million, covering preclinical, development, regulatory, and commercial stages [2] Research Collaboration - The collaboration involves joint preclinical research, with MapLight holding exclusive rights for clinical development and commercialization of the compounds [2] - SandboxAQ will utilize its AI platform to enhance the discovery and development of therapies, focusing on receptor structure-functional activity and ligand-receptor interactions [3][4] Technological Advancements - SandboxAQ's AQBioSim platform allows for precise simulation and prediction of molecular interactions with GPCRs, facilitating a systematic exploration of chemical space [4] - The collaboration aims to accelerate the generation and optimization of potential drug candidates through rapid Design-Make-Test-Analyze (DMTA) cycles [3][4] Company Backgrounds - SandboxAQ is a B2B company that integrates AI and quantum techniques, emerging from Alphabet Inc. and focusing on various sectors including life sciences [5] - MapLight Therapeutics is a clinical-stage biopharmaceutical company dedicated to addressing CNS disorders through circuit-specific pharmacotherapies, leveraging expertise in psychiatry and neuroscience [6]