Autoimmune disease rates sharply increase after age 50, with cases often unrecognized for years, according to a Mayo Clinic study https://t.co/LOtmn0BWVz ...

Autoimmune disease rates sharply increase after age 50, with cases often unrecognized for years, according to a Mayo Clinic study https://t.co/5basIag9Aw ...

It all started with a headache. A headache that turned into pain in every part of my body. A pain that has stayed with me since I was 9 years old for every second of my life. I was always known as the girl who always missed school. Every time my friends would come and sleep over, they would joke that my room was built more like a pharmacy than anything else. For 11 years, I didn't know what was wrong with me. My disease remained undiagnosed. How do you fight something you can't see? How do you fight somethi ...

Summary of Kyverna Therapeutics Conference Call Company Overview - **Company**: Kyverna Therapeutics (NasdaqGS:KYTX) - **Focus**: Pioneering CAR T therapies for autoimmune diseases, specifically targeting stiff person syndrome and myasthenia gravis [2][3][4] Key Points and Arguments CAR T Therapy Development - Kyverna is advancing its unique CAR T construct, **KYV101**, designed for autoimmune diseases, emphasizing improved safety while maintaining potency and efficacy [2][3] - Over **100 patients** have been treated with KYV101, showing no high-grade CRS or ICANS, which de-risks the therapy for pivotal clinical studies [3] - The company aims to be the **first to launch CAR T therapies** for stiff person syndrome and myasthenia gravis, with FDA alignment on clinical pathways [3][9] Strategic Focus - The strategy includes a focus on **neuroimmunology** with KYV101 and a next-generation construct, **KYV102**, aimed at broadening patient access and reducing costs [4][10] - The company is targeting larger indications like **multiple sclerosis (MS)** and **rheumatoid arthritis (RA)**, which have significant unmet needs [5][10] Clinical Results - Early results from KYV101 show significant clinical reductions in symptoms for patients with stiff person syndrome and myasthenia gravis, with some patients achieving over **50-60%** improvement in the time 25-foot walk test [13][14] - Patients have been able to eliminate background immunosuppressants, indicating a transformative impact on their treatment [14][21] Market Opportunity - The market for stiff person syndrome is estimated to have **6,000 confirmed patients** in the U.S., with a significant portion being severely refractory to existing treatments [16][17] - For myasthenia gravis, up to **50%** of treated patients have inadequate symptom control, representing a substantial market opportunity [25][26] Financial Position - Kyverna is in a strong financial position with a cash runway extending into **2027**, supported by recent debt financing [31] Future Directions - The company is focused on advancing KYV101 for stiff person syndrome and myasthenia gravis, with plans to file for IND for KYV102 by the end of the year [28][31] - There is potential for expansion into additional indications as data matures [29] Additional Important Insights - The current treatment landscape for stiff person syndrome lacks approved therapies, highlighting the urgency and potential impact of KYV101 [11][12] - The economic burden of managing these autoimmune diseases is significant, with costs reaching **hundreds of thousands of dollars** annually, underscoring the health economic benefits of CAR T therapy [8][9] - The company emphasizes the **first-mover advantage** in the CAR T space for autoimmune diseases, which could set commercial pricing and market access standards [30][31]

There's a season of life we all go through when your friends start getting married, buying their first homes, landing promotions, and starting families. It's a stage of life that's full of celebrations and milestones and forward motion. It was during this stage of my life, as everyone around me was accelerating, that I felt like I was caught in a state of inertia.I was in a health crisis. I was watching the world move around me while I stayed still. It was during my mid20s after countless unexplained visits ...

Personal Experience & Disability Awareness - The speaker shares personal experiences with multiple sclerosis and related disorders, highlighting the challenges of living with an often invisible disability [1] - The speaker discusses the societal perception of disability, moving from pity and charity to empathy and understanding [1] - The speaker emphasizes the importance of empathy and small acts of kindness in making the world more livable for people with disabilities [1][2] Healthcare & Medical Diagnosis - The speaker recounts a decade-long journey of medical diagnoses, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and MOG antibody-associated disease [1] - The speaker describes the impact of these conditions on physical abilities, including walking, talking, and vision [1] - The speaker mentions undergoing chemotherapy as part of the treatment [1] Societal Barriers & Invisible Disabilities - The speaker describes the challenges of navigating societal barriers, such as using elevators designated for people with disabilities and facing disbelief or questioning [1] - The speaker highlights the emotional and physical exhaustion of constantly translating one's body and negotiating pain levels due to an invisible disability [1] - The speaker points out that the real barrier is not the physical one, but the silence, disbelief, and discomfort encountered from others [1]

Novartis succeeded in treating a form of autoimmune disease in late-stage studies, offering a boost for the Swiss drugmaker’s potential for treatments in the field https://t.co/LimHNRRlYA ...

Health & Wellness Insights - The speaker was diagnosed with an autoimmune disease in 2021, resulting in 44% lung capacity [1] - Approximately 1 in 5 Canadians, nearly 8 million people, live with an autoimmune disease [2] - Narrative research indicates that two-thirds of Canadians adopted a new hobby after the pandemic started [12] Personal Development & Resilience - The speaker chose to engage in a high-intensity sport (tennis) despite physical limitations [1][8] - The speaker highlights the importance of starting despite limitations, choosing play over perfection, listening to the body, and finding a supportive community [16][17][18] - The speaker emphasizes that effort matters more than ease and that showing up imperfectly is better than quitting [15] Benefits of Hobbies & Activities - Hobbies can improve mental health by reducing stress and lifting mood [12] - Hobbies can boost physical health, leading to better sleep and stronger muscles [13] - Hobbies can improve social connection, especially during difficult times [13]