Core Insights - Lexeo Therapeutics, Inc. has announced key senior leadership appointments to enhance its expertise in cardiovascular medicine and late-stage clinical development [1] - The company provided an update on its strategic partnership with Perceptive Xontogeny Venture Funds and venBio Partners to develop therapies for genetic cardiac diseases using a novel non-viral RNA platform [1] Leadership Appointments - Dr. Narinder Bhalla has been appointed as Chief Medical Officer, bringing over 20 years of experience as an interventional cardiologist and nearly a decade in biopharma leadership [2] - Eric Adler, previously Head of Research at Lexeo, will serve as President and CEO of Myoventive, a company co-founded by Lexeo to address genetic cardiac diseases [3] - José Manuel Otero has been appointed Chief Operating Officer, transitioning from Chief Technical Officer, to further elevate performance across Lexeo's operations [4] - Dr. Hayes Dansky has joined as Vice President, Late-Stage Cardiology Development, with extensive experience in cardiovascular research and development [4] - Dr. Greg Aubert has been named Vice President, Early-Stage Cardiology Development and Translational Science, specializing in cardiovascular genetics and gene therapy [4][5] Company Mission and Pipeline - Lexeo Therapeutics is focused on reshaping heart health by developing therapies targeting the underlying genetic causes of cardiovascular diseases [6] - The company is advancing a portfolio of therapeutic candidates, including LX2006 for Friedreich ataxia cardiomyopathy and LX2020 for plakophilin-2 arrhythmogenic cardiomyopathy [6]

Table of Contents As filed with the Securities and Exchange Commission on April 6, 2023. Registration No. 333-269775 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 1 to FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 WINDTREE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation or organization) 2836 (Primary Standard Industrial Classification Code Number) 94-3171943 (I.R.S. Emp ...