Core Insights - enGene Holdings Inc. is positioned strongly at the end of 2025, with completed enrollment in the LEGEND pivotal cohort and a cash position of $342.4 million, extending its financial runway into the second half of 2028 [2][9] - The company aims to file a Biologics License Application (BLA) in the second half of 2026, with potential approval anticipated in 2027 [2][14] Financial Performance - For the full year ended October 31, 2025, total operating expenses were $123.2 million, a significant increase from $62.3 million in 2024, primarily due to higher research and development costs [10][24] - The net loss attributable to common shareholders was approximately $117.3 million, or $2.29 per share, compared to a net loss of $55.1 million, or $1.46 per share, for the previous year [11][25] - As of October 31, 2025, cash, cash equivalents, and marketable securities totaled $202.3 million, with an additional $140.1 million raised from a public offering in November [9][26] Clinical Development Updates - The LEGEND pivotal cohort has completed enrollment of 125 patients, exceeding the target by 25%, and has shown a generally favorable tolerability profile [3][4] - Recent data from the LEGEND trial indicated a 63% complete response (CR) rate at any time, with 56% at 3 months and 62% at 6 months for post-baseline assessments [6][17] - The company is also participating in the FDA's Chemistry, Manufacturing, and Controls (CMC) Development and Readiness Pilot (CDRP) program, which aims to facilitate the development of therapies with compressed clinical timelines [5][16] Corporate Developments - enGene appointed Hussein Sweiti, M.D., MSc, as Chief Medical Officer, bringing over 15 years of experience in oncology clinical research and drug development [8] - The company successfully closed a public offering of common shares and pre-funded warrants, raising $140.1 million in net proceeds [4]

教育理念与方法 - 教师应首先与学生建立稳固的关系，再传授知识，沟通是关键 [1] - 传统教学方法已不适用于当今学生，需要简化课程内容，例如“利比亚化学”[1] - 课堂环境对学生的学习吸收有显著影响，适宜的环境可提高 68% 的学习效率 [1] - 教学应以学生为中心，根据学生特点采用不同的教学策略，如游戏、谜题和实验 [1] - 鼓励在教学中融入幽默元素，通过“多巴胺学习”提高长期记忆力 40% [2] - 教师的职责不应止于课程结束，而应持续关注学生的成长，提供职业规划等方面的支持 [2] 学生发展与潜力 - 每个学生都是独特的个体，都有发展的潜力，不存在“迟钝”或“无用”的学生 [1][2] - 通过适当的引导和鼓励，即使是看似“惰性”的学生也能发生积极的转变，成为对社会有贡献的人 [1][2] 教师角色与责任 - 教师不仅是知识的传递者，更是学生的引路人，帮助学生找到自我价值和发展方向 [1][2] - 教师应努力帮助学生将分散的知识点整合起来，引导他们认识到自己的潜力 [1]