Workflow
Diagnostic tests
icon
Search documents
How persistent pathogens could accelerate the aging process | Amy Proal | TEDxBoston
TEDx Talksยท 2025-11-21 17:02
[applause] I'm here to tell you that I think most of you will fail to extend your health spans. And that's because the aging models you're using to guide healthspan intervention choices do not account for one of the biggest root cause drivers of human aging. the viral, bacterial, parasite, and other pathogens that can infect and persist in your tissues across the course of your life.All of us, often starting in the womb, acquired from our mothers, and then via close contact, ingested foods and other exposur ...
Castle Biosciences(CSTL) - 2025 Q2 - Earnings Call Presentation
2025-08-04 20:30
Financial Performance & Growth - Q2 2025 total test reports for core revenue drivers (DecisionDx-Melanoma, TissueCypher) increased by 33% year-over-year compared to Q2 2024[14, 61] - Gross Margin for Q2 2025 was 77%, while Adjusted Gross Margin reached 80%, slightly lower than the 81% and 83% respectively in the same period of 2024[14] - Net cash provided by operations in Q2 2025 was $20.8 million, a decrease from $24.0 million in Q2 2024[14] - As of June 30, 2025, the company's cash, cash equivalents, and marketable investment securities totaled $275.9 million[14] - Net income for Q2 2025 was $4.5 million, and Adjusted EBITDA was $10.4 million[14] Strategic Initiatives - The company aims to achieve operating cash flow positivity by the end of 2025[4, 60] - The company closed its acquisition of Previse, a gastrointestinal health company, focusing on chronic acid reflux related diseases, including esophageal cancer[14] - The company entered into a collaboration and license agreement with SciBase to develop diagnostic tests for dermatologic diseases[14] Market Penetration & Clinical Utility - DecisionDx-Melanoma clinical use is associated with improved patient survival, with a 29% lower 3-year melanoma-specific mortality and a 17% lower 3-year overall mortality in tested patients compared to untested patients[38] - DecisionDx-SCC Class results predict an SCC patient's individual metastatic risk and individual benefit of ART[44] - TissueCypher is the strongest independent predictor of progression to HGD or EAC in Barrett's esophagus patients, detecting 62% of progressors[51, 52]