Group 1 - Hand, foot, and mouth disease (HFMD) is a common infectious disease primarily affecting children, particularly those under 5 years old, with the highest risk in ages 1-2 [2][3] - The disease can occur year-round, but peaks are observed in spring (April to July) and autumn (September to November) [3] - Symptoms include fever, red spots, blisters, or ulcers on hands, feet, mouth, and buttocks, along with possible cough and loss of appetite [3] Group 2 - The primary transmission routes are fecal-oral, close contact, and droplet transmission [4][5] - Preventive measures include vaccination, good hygiene practices, environmental protection, and enhancing children's immunity [6] - The EV-A71 virus is the most severe among the enteroviruses causing HFMD, and vaccination against it does not provide protection against other strains [7] Group 3 - In case of infection, mild cases require home care, including isolation, fever management, and oral care [9] - Immediate medical attention is necessary if severe symptoms arise, such as persistent high fever, lethargy, rapid breathing, or signs of dehydration [9]