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复星医药:控股子公司许可口服小分子GLP-1R激动剂全球独家权利给辉瑞
Hua Er Jie Jian Wen· 2025-12-09 11:47
Core Transaction Details - The company has licensed the global exclusive rights for the oral small molecule GLP-1R agonist (including YP05002) for development, production, and commercialization to Pfizer [1] - The licensing scope covers all therapeutic, diagnostic, and preventive areas for humans and animals globally [1] Key Financial Terms - Upfront payment of $150 million (non-refundable) [1] - Development milestones up to $350 million based on clinical and commercialization progress [1] - Sales milestones up to $1.585 billion based on annual net sales achievements [1] - Royalties to be paid as a double-digit percentage of annual net sales [1] Product Overview - YP05002 is an oral small molecule GLP-1R agonist developed by the company [1] - Indications include type 2 diabetes, obesity, and metabolic dysfunction-related fatty liver disease [1] - Currently in Phase I clinical trials in Australia [1] Major Risks - Drug development carries inherent uncertainties, and milestone payments are subject to triggering risks [1] - Pfizer has the right to terminate the agreement with written notice [1]