Summary of Acadia Pharmaceuticals (ACAD) R&D Day - June 25, 2025 Company Overview - Acadia Pharmaceuticals focuses on advancing care for patients with underserved neurological and rare diseases, guided by a mission to address high unmet needs in these areas [4][5][11] - The company has two profitable brands, NUPLAZID and Debut, which are expected to generate over $1 billion in combined revenue for the first time in 2025 [5][11] Financial Performance - NUPLAZID is projected to achieve net sales between GBP $650 million and GBP $690 million in 2025, reflecting a 7% to 13% year-over-year growth [6] - Debut is expected to generate net sales between $380 million and $405 million, indicating a 916% growth [7] - The total peak sales potential for NUPLAZID and Debut combined could reach between $1.5 billion and $2 billion [12] Pipeline and Future Growth - Acadia has a robust pipeline with nine disclosed programs, eight of which are expected to be in clinical stages by the end of the year [17] - The company anticipates five study readouts from Phase II or Phase III trials between now and the end of 2027 [17] - The pipeline includes later-stage assets like ACP101 for Prader-Willi syndrome and ACP204 for Alzheimer's disease psychosis, with top-line data expected in 2025 and 2026, respectively [8][17] Key Pipeline Assets 1. **ACP204**: A novel 5-HT2A inverse agonist targeting Alzheimer's and Lewy body dementia psychosis, with a significant unmet need as there are currently no approved therapies for these conditions [24][60] - Approximately 3 million people are affected by psychosis related to these diseases [27] - ACP204 is designed to avoid QT prolongation, allowing for higher dosing and potentially greater efficacy [30][60] 2. **ACP211**: An oral agent with potential ketamine-like efficacy for major depressive disorder (MDD) and treatment-resistant depression (TRD), aiming to minimize sedation and dissociation [62][81] - MDD affects approximately 21 million adults in the U.S., with only 9 million receiving treatment [67] - The drug is designed to provide rapid antidepressant effects without the severe side effects associated with current treatments [81] Strategic Focus - Acadia's growth strategy is anchored in precision medicine, data innovation, globalization, and patient empowerment [4] - The company aims to expand into adjacent rare disease categories, leveraging its scientific approach and internal capabilities [11] Market Opportunity - The potential market for the pipeline assets is significant, with an estimated combined peak sales potential of up to $12 billion if all five pipeline assets succeed [12][13] - Acadia believes that the current market undervalues its clinical programs, and it is committed to delivering data and executing its strategy to unlock this potential [13] Conclusion - Acadia Pharmaceuticals is positioned for transformational growth through its innovative pipeline and strong commercial brands, addressing critical needs in neurological and rare diseases while aiming to enhance patient care and outcomes [2][4][11]

Core Insights - OP Financial Group reported a strong operating profit of EUR 423 million for Q1 2025, despite a 31.4% decrease compared to the same period in 2024, reflecting challenges in the operating environment [2][13][32] - The economic outlook remains uncertain due to geopolitical tensions and trade wars, with GDP growth in Finland projected at 1% for the year [9][10][48] Financial Performance - Total income decreased by 17.1% to EUR 989 million, while total expenses increased by 10% to EUR 590 million, leading to a weakened cost/income ratio of 60% [2][17][32] - Net interest income fell by 11% to EUR 631 million, with Retail Banking experiencing a 17% decline [4][33] - The Corporate Banking segment saw an operating profit increase of 13% to EUR 145 million, while the Insurance segment reported an operating loss of EUR -14 million [18][32] Business Segments - Retail Banking's operating profit decreased by 23% to EUR 291 million, with a 4% increase in deposits to EUR 64 billion [4][18] - Corporate Banking's loan portfolio grew by 1% to EUR 28.2 billion, with deposits increasing by 14% [4][18] - The Insurance segment's service result improved to EUR 2 million, but investment income plummeted by 88% to EUR 19 million [4][16] Customer Engagement and Initiatives - OP Financial Group increased OP bonuses for owner-customers by 40% compared to 2022, providing significant value during economically challenging times [13][32] - The number of systematic investment agreements increased by 22%, indicating strong customer interest in long-term investments [22][23] Capital and Liquidity - The CET1 ratio stood at 20.0%, exceeding the minimum regulatory requirement by 6.9 percentage points, indicating strong capital adequacy [14][42] - The liquidity position remains robust, with a liquidity coverage ratio (LCR) of 202% [42] Market Trends - The loan portfolio grew by 1% year-on-year to EUR 99.1 billion, with deposits increasing by 5% to EUR 77.5 billion [19][20] - The ratio of non-performing exposures decreased to 2.5%, reflecting improved credit quality [21][34] Outlook - The operating profit for 2025 is expected to be good but lower than in 2023 and 2024, amid a challenging economic environment [48][49]