Core Viewpoint - The company has signed an exclusive licensing agreement with CALICO LIFE SCIENCES LLC for the development, production, and commercialization of IL-11 targeted therapies outside of Greater China, which is expected to enhance its clinical research and long-term development strategy [5][8]. Group 1: Licensing Agreement Details - The agreement allows CALICO to exclusively develop, produce, and commercialize the licensed products in all regions except Greater China [5][7]. - The company will receive an upfront payment of $25 million and potential milestone payments totaling up to $571 million, along with tiered royalties based on net sales of the licensed products [7][8]. - The agreement is not classified as a related party transaction and does not constitute a major asset restructuring as per relevant regulations [5][8]. Group 2: Company and Partner Information - CALICO LIFE SCIENCES LLC, founded in September 2013, focuses on aging biology and age-related diseases, aiming to enhance understanding of biological mechanisms controlling human aging [5][6]. - The CEO of CALICO is Arthur D. Levinson, and the company operates from South San Francisco, California [5][6]. Group 3: Agreement Conditions and Impact - The agreement will take effect upon approval at the company's shareholder meeting and is governed by California law [7][8]. - The collaboration is expected to leverage both parties' strengths, promoting resource sharing and mutual benefits, while not affecting the company's main business or independence [8].

Core Viewpoint - Maiwei Biotech has signed an exclusive licensing agreement with CALICO for IL-11 targeted therapy, including 9MW3811, allowing CALICO to develop, produce, and commercialize the product outside Greater China [1] Group 1: Licensing Agreement Details - The agreement grants Maiwei Biotech exclusive rights to license CALICO for the development, production, and commercialization of the product in all regions except Greater China (Mainland China, Hong Kong, Macau, and Taiwan) [1] - Maiwei Biotech will receive an upfront payment and milestone payments, as well as tiered royalties based on net sales of the licensed product [1] Group 2: Product Information - 9MW3811 is a humanized monoclonal antibody developed by Maiwei Biotech that effectively blocks the activation of IL-11 downstream signaling pathways, aiming to treat fibrosis and tumors [1] - The product has received approval for clinical trials in China, Australia, and the United States, with Phase I clinical studies completed in China and Australia [1] Group 3: Financial Aspects - CALICO will pay an upfront non-refundable payment of $25 million to Maiwei Biotech [1] - Additionally, Maiwei Biotech could receive up to $571 million in potential milestone payments related to near-term, development, registration, and commercialization, along with tiered royalties based on net sales of the licensed product [1]