Core Insights - The U.S. Centers for Medicare and Medicaid Services (CMS) has negotiated lower prices for 15 high-cost medications, leading to significant annual savings on prescription expenses [1][3] - The new prices, effective in 2027, include a monthly cost of $274 for Novo Nordisk's GLP-1 drug, semaglutide, marketed as Wegovy, Ozempic, and Rybelsus [2] - Other drugs, such as AstraZeneca's Calquence, Boehringer's Ofev, and Pfizer's Ibrance, have seen price reductions of 40%-50% from their estimated net prices, with Medicare enrollees expected to save approximately $685 million in out-of-pocket costs and Medicare itself saving $12 billion [3] Drug Price Reductions - The changes are part of the Inflation Reduction Act (IRA) signed into law by former President Joe Biden, aimed at reducing drug costs for Medicare beneficiaries [4] - The pharmaceutical industry has faced pressure to lower drug prices, with recent agreements to reduce costs for weight-loss drugs like Zepbound and Wegovy, bringing patient costs down to $50–$350 per month from over $1,000 [5] - Pfizer was the first company to reach an agreement under the Trump administration to align U.S. drug prices with the lowest prices in other developed countries [6]