Key Takeaways RVMD reported a Q4 2025 loss of $1.86 per share, wider than estimates, with no revenues.Revolution Medicines expects 2026 operating expenses of $1.6B-$1.7B, including stock-based pay.Revolution Medicines advanced daraxonrasib into multiple late-stage studies in PDAC and NSCLC.Revolution Medicines (RVMD) reported a fourth-quarter 2025 loss of $1.86 per share, wider than the Zacks Consensus Estimate of a loss of $1.56. The company had incurred a loss of $1.12 in the year-ago quarter.Currently, R ...

Aristotle Funds, an investment advisor, released its “Growth Equity Fund” fourth-quarter 2025 investor letter. A copy of the letter can be downloaded here. U.S. equity markets reached new all-time highs in Q4 2025, with the S&P 500 Index rising 2.66% and the Bloomberg U.S. Aggregate Bond Index increasing by 1.10%. Within the Russell 1000 Growth Index, healthcare, communication services, and financials were the top-performing sectors, while utilities, real estate, and materials lagged. The U.S. economy show ...

Revolution Medicines (NasdaqGS:RVMD) Q4 2025 Earnings call February 25, 2026 04:30 PM ET Company ParticipantsAlan Sandler - Chief Development OfficerAnthony Mancini - Chief Global Commercialization OfficerAsthika Goonewardene - Managing Director, Equity ResearchJack Anders - CFOMark A. Goldsmith - Chairman and CEOPoorna Kannan - Biotech Equity Research AssociateRyan Aase - Senior Vice President of Corporate AffairsSteve Kelsey - President, Research and DevelopmentWei Lin - Chief Medical OfficerConference Ca ...

On track for readout of RASolute 302, a Phase 3 trial of daraxonrasib in second line metastatic PDAC, in first half of 2026Continues to advance broad late-stage pipeline, with five ongoing Phase 3 trials and three additional Phase 3 trials planned to initiate in 2026Expects to substantially complete enrollment in RASolve 301, a Phase 3 trial of daraxonrasib in previously treated NSCLC, this yearInitiated RASolute 305, the first Phase 3 trial for zoldonrasib, in first line metastatic PDAC harboring a RAS G12 ...

Summit Therapeutics (NasdaqGM:SMMT) Q4 2025 Earnings call February 23, 2026 04:30 PM ET Company ParticipantsAllen Yang - Chief R&D Strategy OfficerDave Gancarz - Chief Business and Strategy OfficerJosh Schimmer - Senior Managing Director and Leader in Biotechnology Equity ResearchMaky Zanganeh - Co-CEO and PresidentManmeet S. Soni - COO and CFOMark Schwartz - Vice ChairmanRobert Duggan - Co-Chief Executive Officer and Chairman of the BoardConference Call ParticipantsAsthika Goonewardene - Managing Director ...

Core Insights - Revolution Medicines has initiated its first-in-human clinical trial for RMC-5127, a selective inhibitor targeting the RAS G12V mutation, which is prevalent in various cancers [1][2][3] Company Overview - Revolution Medicines is a late-stage clinical oncology company focused on developing targeted therapies for RAS-addicted cancers [4] - The company's R&D pipeline includes multiple RAS(ON) inhibitors, with RMC-5127 being the fifth disclosed mutant-selective inhibitor and the fourth in clinical development [3][4] Clinical Trial Details - The trial, named RMC-5127-001, is an open-label study assessing the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of RMC-5127 as both a monotherapy and in combination settings [2] - It will enroll patients with RAS G12V–mutated solid tumors, including pancreatic ductal adenocarcinoma (PDAC), colorectal cancer (CRC), and non–small cell lung cancer (NSCLC), who have either progressed on or are intolerant to prior standard therapies [2] Market Opportunity - RAS G12V is the second most common RAS mutation, with approximately 48,000 new cases diagnosed annually in the U.S., primarily among patients with PDAC, CRC, or NSCLC [3]

Summary of Revolution Medicines FY Conference Call Company Overview - **Company**: Revolution Medicines (NasdaqGS:RVMD) - **Industry**: Biotechnology, specifically focused on oncology and RAS-addicted cancers - **Mission**: To revolutionize treatment for patients with RAS-addicted cancers through innovative targeted medicines [2][3] Core Points and Arguments Clinical Development and Pipeline - Revolution Medicines is advancing in three major RAS-addicted cancers: pancreatic, non-small cell lung, and colorectal cancer [3] - The company has four RAS(ON) inhibitors in clinical trials and a deep pipeline, with eight ongoing or announced registrational phase 3 trials [3] - **Key Investigational Drugs**: - **RMC-6236**: A multi-selective RAS(ON) inhibitor with promising clinical profiles [3][6] - **RMC-6291**: A selective inhibitor for RAS G12C mutations [3] - **RMC-9805**: A selective inhibitor for RAS G12D mutations [3] - **RMC-5127**: A selective inhibitor for RAS G12V mutations [3] Market Need and Unmet Needs - Over 90% of pancreatic ductal adenocarcinoma tumors harbor an oncogenic RAS mutation, indicating a significant need for targeted therapies [4] - Approximately 30% of non-small cell lung cancers and over 50% of colorectal cancers also carry oncogenic RAS mutations, highlighting the unmet need for effective treatments [5] Clinical Trial Highlights - **Pancreatic Cancer**: - RMC-6236 has shown promising clinical durability in second-line treatment settings compared to standard cytotoxic chemotherapy [6][10] - Ongoing trials include RASolute 302, 303, and 304, focusing on various treatment regimens [8][10] - **Non-Small Cell Lung Cancer**: - RMC-6236 is being evaluated in RASolute 301, with encouraging early data from combination therapies [12][13] - RMC-9805 and RMC-6291 are also being explored for their roles in treating specific RAS mutations [13][15] - **Colorectal Cancer**: - The company is pursuing combination studies to maximize clinical impact due to the heterogeneous nature of these cancers [15][16] Innovation and Future Directions - Introduction of a new class of RAS(ON) inhibitors designed to overcome drug resistance, with plans to advance the first compound into clinical trials [19][21] - Continuous investment in research and development to maintain leadership in targeted therapeutics for RAS-addicted cancers [17][22] Financial Position - As of Q3 2025, Revolution Medicines reported a strong financial position with $1.9 billion in cash and an additional $1.75 billion in committed capital from Royalty Pharma [23] - The company is well-positioned for broad execution across its clinical programs and operational capabilities [23] Upcoming Milestones - Key data disclosures for RMC-6236 and RMC-9805 are expected in the first half of 2026, including results from ongoing trials [24][25] - Plans to initiate new registrational trials for both pancreatic and non-small cell lung cancers in 2026 [24][25] Other Important Content - The company emphasizes the importance of data maturity before disclosure, aiming to provide relevant information to support clinical programs [28][30] - Concerns regarding external factors affecting trial outcomes and regulatory processes were acknowledged, highlighting the unpredictability of clinical research [34][36] - The differentiation of ZOLD on RASIB was discussed, noting its favorable tolerability profile and potential as a class-leading compound [39][40] This summary encapsulates the key points from the Revolution Medicines FY Conference Call, focusing on the company's strategic direction, clinical advancements, market needs, and financial health.

On Target to Outsmart Cancer 44th Annual JP Morgan Healthcare Conference January 12, 2026 © 2026 Revolution Medicines, Inc. 2 Legal Disclaimer This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act. All statements other than statements of historical facts contained in this presentation, including statements regarding our future results of operations and financial position, business strategy, prospective products, availability of funding, abil ...

Core Insights - Revolution Medicines, Inc. is set to report its financial results for Q3 2025 on November 5, 2025, after market close [1] - A webcast will be hosted by the senior management team at 4:30 p.m. ET to discuss the financial results and corporate progress [1] Company Overview - Revolution Medicines is a late-stage clinical oncology company focused on developing targeted therapies for RAS-addicted cancers [3] - The company's R&D pipeline includes RAS(ON) inhibitors such as daraxonrasib (RMC-6236), elironrasib (RMC-6291), and zoldonrasib (RMC-9805), which are currently in clinical development [3] - The company plans to advance RMC-5127, a RAS(ON) G12V-selective inhibitor, into clinical development next [3] - Additional pipeline opportunities include RAS(ON) mutant-selective inhibitors like RMC-0708 (Q61H) and RMC-8839 (G13C) [3]

Core Insights - Revolution Medicines, Inc. has appointed Alan Sandler, M.D. as the chief development officer to enhance its leadership in developing targeted therapies for RAS-addicted cancers [1][2] - The company has also appointed Alicia Gardner and Gerwin Winter as regional general managers for the U.S. and Europe, respectively, to strengthen its global commercial capabilities [3] Company Overview - Revolution Medicines is a late-stage clinical oncology company focused on developing novel targeted therapies for patients with RAS-addicted cancers [4] - The company's R&D pipeline includes RAS(ON) inhibitors such as daraxonrasib (RMC-6236), elironrasib (RMC-6291), and zoldonrasib (RMC-9805), which are currently in clinical development [4] - The company anticipates that RMC-5127, a RAS(ON) G12V-selective inhibitor, will be the next to enter clinical development, with additional opportunities focusing on RAS(ON) mutant-selective inhibitors [4]