Core Insights - IGI Therapeutics SA and AbbVie Inc. have entered into an exclusive licensing agreement for IGI's investigational asset ISB 2001, aimed at oncology and autoimmune diseases [1][2] - AbbVie will have exclusive rights to develop, manufacture, and commercialize ISB 2001 in North America, Europe, Japan, and Greater China [2] Financial Terms - IGI will receive an upfront payment of $700 million and is eligible for up to $1.225 billion in milestone payments, along with tiered, double-digit royalties on net sales [3] - The total potential financial benefit for IGI from this agreement could reach $1.925 billion [3] Product Details - ISB 2001 is a first-in-class trispecific T-cell engager targeting BCMA and CD38 on myeloma cells and CD3 on T cells, currently in Phase 1 for relapsed/refractory multiple myeloma [3] - Recent data from a study presented at the 2025 ASCO Annual Meeting showed a sustained overall response rate (ORR) of 79% and a complete/stringent complete response (CR/sCR) rate of 30% in heavily pretreated relapsed/refractory myeloma patients [4] Regulatory Status - The U.S. FDA granted ISB 2001 Orphan Drug Designation in July 2023 and Fast Track Designation for relapsed/refractory myeloma patients in May 2025 [5] Market Context - Other companies in the industry are also pursuing significant partnerships, such as AstraZeneca's reported talks with Summit Therapeutics for a $15 billion deal and BioNTech's agreement with Bristol Myers Squibb involving $1.5 billion upfront [5][6] - AbbVie’s stock price increased by 2.63% to $195.63 following the announcement [7]

Key Takeaways SMMT surged after reports of AstraZeneca exploring a $15 billion licensing deal for ivonescimab. The deal may include billions upfront, with milestone payments tied to Ivonescimab's progress. Ivonescimab showed superiority over Keytruda and Tevimbra in late-stage NSCLC trials.Shares of clinical-stage company Summit Therapeutics (SMMT) rose nearly 9% on Thursday following a report issued by Bloomberg, which stated that pharma giant AstraZeneca (AZN) is in discussions with the company for a po ...

业 及 产 业 2025 年 07 月 06 日 本周医药上涨 3.6%，创新药及高 端器械再迎支持政策，医保目录谈 判正式启动，AZ/Summit 或达成 超 150 亿美元交易 看好 ——医药行业周报（2025/6/30-2025/7/4） 本期投资提示： 证 券 研 相关研究 《创新药持续高增，上游现复苏趋势—— 医药生物行业 25Q2 业绩前瞻》 2025/07/04 《本周医药上涨 1.6%，医保目录调整将首 度纳入商保创新药目录，荣昌泰它西普完 成超 40 亿美元授权——医药行业周报 （2025/6/23-2025/6/27）》 2025/06/29 《本周医药下跌 4.4%，创新药械再迎审评 审批端支持政策，圣诺 25H1 预告利润高 增——医药行业周报（2025/6/16- 2025/6/20）》 2025/06/22 证券分析师 张静含 A0230522080004 zhangjh@swsresearch.com 李敏杰 A0230523070006 limj2@swsresearch.com 联系人 李敏杰 (8621)23297818× limj2@swsresearch.com 本研究 ...

Is it worth it to buy a stock after it experiences significant market gains? The answer is, it depends. Some companies don't have much growth fuel left in the tank after a nice run, while others still boast significant upside potential after juicy gains. It's best to stay away from the former, but the investing wisdom according to which we should "buy low" still applies to the latter.Let's consider two companies that have performed exceptionally well recently but still have excellent long-term prospects: Su ...

AstraZeneca (AZN -2.36%) might soon be on the hook for an eventual 11-figure payout, and investors weren't all that comfortable with this. A Bloomberg article published Thursday morning said that the company is pursuing what might end up being an expensive partnership with a biotech.A cautious market traded AstraZeneca stock down by more than 2% following the report, on a day when the S&P 500 index landed firmly in positive territory with a 0.8% gain.That's one big price tagThe article that dinged AstraZene ...

One day before the July Fourth holiday, the stock of clinical-stage biotech Summit Therapeutics (SMMT 8.18%) exploded like a powerful fireworks display. Shares of the cancer-focused company leaped by 8%, on a media report that a well-known peer was interested in a licensing deal. That rise bettered the S&P 500's (^GSPC 0.83%) 0.8% increase by several orders of magnitude. 15 billion new reasons to consider the stockThe media outlet in question was Bloomberg, which that morning published an article asserting ...

Group 1 - Akeso, Inc. has successfully enrolled the first patient in its Phase Ia clinical trial for AK146D1, a bispecific Antibody-Drug Conjugate (ADC) targeting Trop2 and Nectin4, marking its first bispecific ADC to enter clinical trials [1] - AK146D1 has received approvals from the U.S. FDA, Australia's TGA, and China's NMPA to begin clinical trials, indicating strong regulatory support for the product [1] - Akeso is the only company globally with two approved cancer immunotherapy bispecific antibodies, cadonilimab and ivonescimab, establishing a strong leadership advantage in the IO+ADC space [2] Group 2 - ADC therapeutics are a key component of Akeso's "IO+ADC" 2.0 strategy, which aims to reshape the global treatment landscape and set new standards for cancer care [3] - The company emphasizes the potential of innovative bispecific ADCs like AK146D1 to unlock global clinical opportunities and enhance cancer therapies [4] - Trop2 and Nectin4 are ideal targets for ADC therapy due to their high expression in various tumor types and low expression in normal tissues, which may improve treatment efficacy [4][5] Group 3 - AK146D1 is the first bispecific ADC targeting both Trop2 and Nectin4, with preclinical studies showing strong anti-tumor activity and favorable safety profiles [5] - The development of AK146D1 holds significant potential for improving treatment outcomes for cancer patients, highlighting Akeso's commitment to advancing cancer therapies [5]

REDWOOD CITY, Calif. and MIAMI, June 30, 2025 (GLOBE NEWSWIRE) -- Revolution Medicines, Inc. (Nasdaq: RVMD), a late-stage clinical oncology company developing targeted therapies for patients with RAS- addicted cancers and Summit Therapeutics, Inc. (Nasdaq: SMMT), a biopharmaceutical oncology company focused on patient-friendly medicinal therapies intended to improve quality of life, increase potential duration of life, and resolve serious unmet medical needs, today announced the companies have entered into ...

以下文章来源于投中网 ，作者蒲凡 投中网 . 投中网是领先的创新经济信息服务平台，拥有立体化传播矩阵，为创新经济人群提供深入、独到的智识和洞见，在私募股权投资行业和创新商业领域拥有权 威影响力。官网：www.chinaventure.com.cn 一笔交易直接赚麻了。 文 ｜ 蒲凡 来源｜ 投中网（ID：China-Venture） 封面来源｜ P exels 假如有这样一款神药：它可以有效治疗癌症，走出了一条与化疗的"杀敌一千、自损八百"截然不同的路线，一方面能够阻止恢复患者的T细胞功能，增强身 体对肿瘤的免疫反应，另一方面还能抑制肿瘤部位的血管生成，从而切断肿瘤的营养供应，双管齐下的抑制肿瘤的发展。与此同时，又因为这款神药可 以"双管齐下"，患者还能减少药物种类，降低药物相互作用的风险。 而你是一家制药公司的老板，你的技术顾问告诉你这款神药将成为下一代癌症治疗方案的"主角"，现在你有一个机会买下这款神药的研发权，你愿意出多少 钱？ 美国制药巨头百时美施贵宝的答案是，800亿。 日前，百时美施贵宝与德国生物技术公司BioNTech达成合作协议，获得联合开发和销售抗癌神药PD-L1/VEGF-A双特异性抗体B ...

以下文章来源于投中网 ，作者蒲凡 投中网 . 投中网是领先的创新经济信息服务平台，拥有立体化传播矩阵，为创新经济人群提供深入、独到的智识 和洞见，在私募股权投资行业和创新商业领域拥有权威影响力。官网：www.chinaventure.com.cn 本文来自微信公众号： 投中网 （ID：China-Venture） ，作者：蒲凡，题图来自：AI生成 假如有这样一款神药：它可以有效治疗癌症，走出了一条与化疗的"杀敌一千、自损八百"截然不同的 路线，一方面能够阻止恢复患者的T细胞功能，增强身体对肿瘤的免疫反应，另一方面还能抑制肿瘤 部位的血管生成，从而切断肿瘤的营养供应，双管齐下的抑制肿瘤的发展。与此同时，又因为这款神 药可以"双管齐下"，患者还能减少药物种类，降低药物相互作用的风险。 而你是一家制药公司的老板，你的技术顾问告诉你这款神药将成为下一代癌症治疗方案的"主角"，现 在你有一个机会买下这款神药的研发权，你愿意出多少钱？ 美国制药巨头百时美施贵宝的答案是，800亿。 日前，百时美施贵宝与德国生物技术公司BioNTech达成合作协议，获得联合开发和销售抗癌神药 PD-L1/VEGF-A双特异性抗体BNT327 ...