Group 1 - RNA methylation modification is considered a "switch" for controlling gene expression and is closely related to various diseases, making it a hot topic in biological research [1][2] - A research team at Xi'an Jiaotong-Liverpool University developed a cross-validated RNA methylation modification site database, integrating nearly 1,400 research data points to provide a reliable reference for evaluating experimental conclusions [1] - The database identifies 135,000 high-confidence RNA methylation modification sites and has been utilized by researchers from 24 countries, helping to distinguish reliable biological markers from experimental noise [2] Group 2 - The research team discovered over 6,000 gene variations, some of which are highly correlated with RNA methylation modification sites related to complex diseases such as depression, potentially offering new insights into the molecular mechanisms of these diseases [2]