Company Overview - NRx Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company focused on developing therapeutics for central nervous system disorders, including suicidal bipolar depression, chronic pain, and PTSD [4] - The company is developing NRX-101, which has been designated as an FDA Breakthrough Therapy for suicidal treatment-resistant bipolar depression, with plans to file a New Drug Application (NDA) for Accelerated Approval [4] Recent Developments - NRx Pharmaceuticals has filed an Abbreviated New Drug Application (ANDA) for NRX-100, a preservative-free IV ketamine, for currently approved indications [5] - The company has initiated an NDA filing for NRX-100 for the treatment of suicidal depression, based on clinical trial results and new data from French health authorities [5] - NRx has received Fast Track Designation from the US FDA for the development of NRX-100 to treat patients with acute suicidality and has filed a patent for this novel formulation [5] Events and Collaborations - The CEO and Chairman of NRx Pharmaceuticals will participate in a fireside chat at the BTIG Virtual Biotechnology Conference on July 29-30, 2025, discussing neuroplasticity in CNS disorder treatments [1][2] - The discussion will include insights from Prof. Samuel Wilkinson, a pioneer in the understanding of ketamine and other neuroplastic drugs for treating depression and PTSD [2] Subsidiary Information - HOPE Therapeutics, Inc., a subsidiary of NRx Pharmaceuticals, is establishing a network of interventional psychiatry clinics to provide ketamine and other therapies for suicidal depression and related disorders [6]

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