Core Insights - Immuneering Corporation (IMRX) has entered into a clinical supply agreement with Eli Lilly (LLY) for the KRAS G12C inhibitor, olomorasib (LY3537982) [1] - The agreement supports a planned phase II study evaluating Immuneering's atebimetinib (IMM-1-104) in combination with olomorasib for treating advanced KRAS G12C-mutant non-small cell lung cancer (NSCLC) [2] - Immuneering's shares rose by 21.7% following the announcement, and the stock has increased by 170.5% year-to-date compared to the industry's 4.1% rise [2][3] Agreement Details - The combination of atebimetinib and olomorasib is expected to provide a vertical blockade of the RAS-MAPK pathway, with preclinical data showing enhanced tumor regression and prolonged survival compared to monotherapy [5] - This is Immuneering's second collaboration announcement in 2025, following a similar agreement with Regeneron Pharmaceuticals to evaluate atebimetinib with Libtayo for advanced NSCLC [6][7] - In both agreements, Immuneering retains full worldwide development and commercialization rights to atebimetinib [8] Ongoing Studies - Immuneering is advancing atebimetinib in other cancer studies, including a phase IIa study in combination with modified gemcitabine/nab-paclitaxel for first-line pancreatic cancer [9] - Preliminary data from this study indicated a 94% overall survival and 72% progression-free survival at six months, with updated data expected later in Q3 2025 [10] - The company plans to initiate a pivotal study for atebimetinib in combination with modified gemcitabine/nab-paclitaxel in 2026, pending regulatory feedback [11]

Core Insights - Novo Nordisk (NVO) has faced a significant setback in July, reducing its 2025 sales and profit outlook due to slower-than-expected growth in its semaglutide-based drugs, Wegovy and Ozempic, particularly in the U.S. obesity market [1] - The company is working to diversify its revenue sources beyond GLP-1 drugs, focusing on its Rare Disease franchise, which has seen notable regulatory milestones [2] - The FDA granted accelerated approval for Wegovy to treat noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH), marking a significant advancement in liver care [3] Sales and Market Performance - Eli Lilly's GLP-1 therapies, Mounjaro and Zepbound, have rapidly gained market share, generating combined sales of $14.7 billion in the first half of 2025, accounting for 52% of Eli Lilly's total revenues [4] - Novo Nordisk's stock has underperformed, losing 34.5% year-to-date compared to a 0.3% decline in the industry [6][8] Regulatory Developments - Novo Nordisk has received EU approval for Alhemo to treat hemophilia A and B, enhancing its Rare Disease portfolio [2][8] - Wegovy is now the first GLP-1 therapy approved for MASH, providing a new treatment option for patients with liver disease [3][8] Financial Estimates and Valuation - Earnings estimates for 2025 have decreased from $3.98 to $3.84 per share, while 2026 estimates have dropped from $4.56 to $4.09 [12] - Novo Nordisk's shares are trading at a price/earnings ratio of 14.07, lower than the industry average of 14.85 and significantly below its five-year mean of 29.25 [9]

About this content About Emily Jarvie Emily began her career as a political journalist for Australian Community Media in Hobart, Tasmania. After she relocated to Toronto, Canada, she reported on business, legal, and scientific developments in the emerging psychedelics sector before joining Proactive in 2022. She brings a strong journalism background with her work featured in newspapers, magazines, and digital publications across Australia, Europe, and North America, including The Examiner, The Advocate, ...

Shares of pharmaceutical giant Eli Lilly and Co (NYSE:LLY) are on the rise today, up 3.7% at $720.07 at last check. The company's daily weight-loss pill, orforglipron, met its main goal in a late-stage trial, helping type 2 diabetes patients shed 10.5% of their body weight in 72 weeks. This was the last study needed for Eli Lilly to seek approval for the drug globally. On the charts, LLY has been climbing since its August 8th 52-week low of $623.78, heading for its 10th gain in the last 12 sessions. The sha ...

Key Takeaways The EC approved Gileads lenacapavir, branded Yeytuo, as twice-yearly HIV prevention for at-risk groups.Approval followed accelerated EMA review, CHMP backing, and PURPOSE 1 and 2 trial data.Lenacapavir strengthens Gileads HIV portfolio as Truvada faces generic competition in prevention.Gilead Sciences, Inc. ((GILD) announced that the European Commission (“EC”) has granted marketing authorization to HIV prevention drug lenacapavir, under the brand name Yeytuo.The EC approved lenacapavir, GILD’s ...

Let's get to Jim and stop trading. One of my favorite executives is David Ricks from Eli Liy. He came on after that last trial and that was the uh a trial for weight loss obviously August 7225.He said look our stocks shouldn't be down that much. I mean there's a lot more things in the pipeline. He then bought 1,632 shares at 645 uh August 12th.He said saying basically look we're we're not bad. Well, of course, the new tri another trial came out today, August 26. Same kind, the misinformation thing is so leg ...

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V i e w p o i n t | 22 Aug 2025 05:48:16 ET │ 14 pages Jiangsu Hengrui Pharmaceuticals Share Buy-back for ESOP Set Confident Tone; Recurring BD Revenue Backed by Robust Innovative Pipeline CITI'S TAKE The Rmb15.3/19.2/24.0bn innovative drug sales requirement for 2025- 2027 set the floor for minimum growth – we think it demonstrated confidence, fueled by Hengrui's potential 47 new products/indications approvals in 2025-2027. Hengrui has reached three BD collaborations and booked Rmb2.0bn BD revenue in 1H25, ...

Key Takeaways Amgen shares have climbed 13.5% YTD, outperforming the industry, sector and S&P 500.Strong sales from Repatha, Evenity, Blincyto and new biosimilars offset legacy product declines.Pipeline focus on MariTide and new biosimilars aims to counter Prolia and Xgeva's patent expiries.Amgen’s (AMGN) stock has risen 13.5% so far this year compared with an increase of 1.6% for the industry. The stock has also outperformed the sector and S&P 500 Index, as seen in the chart below.AMGN Stock Outperforms In ...

Key Takeaways AbbVie will pay up to $1.2B to acquire rights to bretisilocin from Gilgamesh.Bretisilocin showed rapid and durable antidepressant effects in phase II studyAbbVie continues neuroscience deal spree to strengthen its early-stage pipeline.AbbVie (ABBV) has announced a deal with private neuroscience biotech, Gilgamesh Pharmaceuticals, to acquire the latter’s lead pipeline candidate, bretisilocin (GM-2505), a novel therapy being developed for treating major depressive disorder(MDD).Gilgamesh is curr ...