Daniel Nadler started OpenEvidence to help physicians sort through a deluge of medical research. Now, he’s raised $210 million at a $3.5 billion valuation.FULL STORY: https://t.co/T3K1X92MNR(Photo: Mauricio Candela for Forbes) https://t.co/ixnSXZRezy ...

Daniel Nadler started OpenEvidence to help physicians sort through a deluge of medical research. Now, he’s raised $210 million at a $3.5 billion valuation. (Photo: Mauricio Candela for Forbes) https://t.co/P9sWDGTDKv https://t.co/2pWELClLbP ...

Core Viewpoint - The article discusses a recent study that highlights the role of fetal-like transcription programs in promoting phenotypic plasticity in colorectal cancer, which is crucial for cancer progression, metastasis, and treatment resistance [2][3]. Group 1: Research Development - A patient-derived organoid model (CiPDO) was developed to capture the fetal-like plasticity state in colorectal cancer [4]. - The CiPDO system was cultivated under specific conditions using EGF, CHIR99021, LDN-214117, and FGF2, allowing for long-term expansion of colorectal cancer cells while retaining fetal-like characteristics [7]. Group 2: Key Findings - The research identified an oncofetal state (OnFS) enriched in advanced tumors, associated with key plasticity features including epithelial-mesenchymal transition, increased metastasis, and enhanced treatment resistance [8]. - Mechanistically, the FGF2-AP-1 signaling pathway was shown to maintain the OnFS program and related phenotypic plasticity in colorectal cancer [9]. Group 3: Implications - The patient-derived organoid model provides a powerful platform for studying the fetal-like characteristics of cancer cells and their roles in tumor progression and treatment resistance in colorectal cancer [11].

Core Viewpoint - The article discusses a breakthrough in reconstructive surgery for ear deformities, utilizing bacteria as a "biological 3D printer" to create customizable artificial ear scaffolds, potentially transforming clinical practices in auricular reconstruction [2][4]. Group 1: Challenges in Traditional Methods - Traditional ear reconstruction methods involve harvesting rib cartilage, which presents three main challenges: insufficient rib cartilage in children requiring multiple surgeries, the complexity of sculpting and stitching that relies heavily on the surgeon's skill, and the risk of postoperative complications such as infections and scaffold exposure [4][5]. - Existing artificial materials used as cartilage substitutes also face issues, including manual shaping and stitching, along with the risk of rejection [4]. Group 2: Innovative Approach - The research team focused on the bacterium Komagataeibacter xylinus, which can synthesize bacterial cellulose known for its high purity, nanoscale network structure, excellent biocompatibility, and functionalization properties [4][5]. - The bacteria exhibit an "oxygen navigation" feature, allowing them to gather in oxygen-rich areas and secrete nanofibers, which are utilized to create the ear scaffold [5]. Group 3: Key Innovations in Scaffold Production - The team designed a high-oxygen-permeable silicone mold to achieve three critical controls: precise molds created from 3D-printed ear models, dynamic oxygen supply to guide bacteria evenly throughout the scaffold, and nanometer-level precision in the cellulose fibers produced [5][7]. - The cellulose fibers have a diameter of 20-100 nanometers and form a cartilage-like network structure with mechanical strength comparable to real ear cartilage, with an elastic modulus ranging from 3.89 to 9.56 MPa [5][8]. Group 4: Performance and Clinical Implications - After 21 days of bacterial "biomanufacturing" and purification, the artificial ear scaffolds demonstrated remarkable characteristics: precise replication of ear structures, high tensile strength with no deformation after 50 days of immersion, long-term stability in the body, and extremely low endotoxin levels [8][9]. - The scaffolds show over 95% survival rates for cartilage and skin cells, allowing for rapid integration with surrounding tissues, indicating significant clinical application potential for personalized ear reconstruction [9]. Group 5: Broader Impact - This research marks the first application of microbial manufacturing technology in organ reconstruction, offering hope for patients with ear deformities and paving the way for future developments in complex tissue engineering, potentially extending to heart valves and vascular networks [9].

Core Insights - The Leukemia & Lymphoma Society (LLS) has partnered with Kroger's Dallas Division to raise funds for The Dare to Dream Project, aimed at improving treatments for pediatric blood cancer patients and providing support for their families [1][2][4] Group 1: The Dare to Dream Project - The Dare to Dream Project is a $175 million campaign focused on funding pediatric blood cancer research, advocating for healthcare policy changes, and expanding support services for affected children and families [8] - Only 5% of cancer drugs have been approved for first-time use in children, and 80% of childhood cancer survivors face chronic health issues due to their treatments [3] Group 2: Fundraising Efforts - From May 14 to June 3, 2025, Kroger encourages customers to donate at checkout in 110 stores across North and East Texas and Louisiana to support LLS's Dare to Dream Project [2] - Funds raised will exclusively benefit the life-saving work of The Dare to Dream Project, helping to ensure better treatment outcomes for children with blood cancer [1][2] Group 3: LLS's Commitment - LLS is pioneering pediatric blood cancer research, including the establishment of the first-ever pediatric AML Data Commons and the launch of the LLS PedAL Master Clinical Trial [4] - The organization has been dedicated to improving the quality of life for blood cancer patients and their families for over 75 years [6]

有很多习惯，我们知道它对健康不利，但总会"不自觉"地放纵自己，比如熬夜、吃高热量的垃圾食品等等—— 但其实，这些坏习惯对我们健康的危害比想象中更严重。 首先，《Nature》子刊的一篇研究论文表明，一系列环境因素，包括生活方式 （例如吸烟、运动锻炼） 和生活条 件，对健康和衰老的影响比遗传因素的影响更大。 其次，睡眠作为人体最基本的生理需求之一，其质量的高低直接关系到免疫系统的功能和整体健康状态。一项 发表在《The Journal of Immunology》的研究指出，即使是短暂的一夜不睡，也会对免疫系统产生显著的负面影 响，使单核细胞的特征发生改变，进而引发慢性炎症和相关疾病的风险增加。 最后，饮食习惯对健康的影响也不容小觑。另一项发表在《Nature》子刊的研究显示，即使是短期的高热量饮 食，也会对大脑结构和功能产生长期的不良影响。 这些研究为我们提供了关于生活习惯对健康影响的有力证据，同时，它们不仅为我们敲响了警钟，也为改善健 康提供了新的方向。 生活方式的影响，远超基因 虽然人类的人均寿命已经突破了80岁，但是我们关于衰老的认知仍然在被不断颠覆——2025年2月19日，牛 津大学的研究人员在国际顶 ...