Financial Data and Key Metrics Changes - Reported revenue for Q3 was $1.62 billion, down 5% year-over-year on an organic basis, primarily due to weaker performance in the Lab segment [13][22] - Adjusted EBITDA margin was 16.5%, with adjusted EPS for the quarter at $0.22, reflecting a $0.04 year-over-year decline [14][22] - Free cash flow was $172 million, with an adjusted conversion rate of 124% [14][22] - Adjusted gross profit was $527 million, representing a 32.4% adjusted gross margin, a decline of 100 basis points year-over-year [14][22] - A $785 million impairment to goodwill associated with the Lab distribution business was recorded, driven by share price weakness and margin headwinds [15] Business Line Data and Key Metrics Changes - Laboratory Solutions revenue was $1.1 billion, down 5% organically year-over-year, below expectations [16][22] - Bioscience production revenue was $527 million, down 4% organically, at the low end of expectations [18][22] - The services business within Laboratory Solutions faced greater than expected headwinds, while proprietary lab chemicals grew mid-single digits [17][22] - Adjusted operating income for Laboratory Solutions was $124 million, with an 11.3% margin, pressured by lower volumes [18][22] - Adjusted operating income for bioscience production was $128 million, representing a 24.2% margin, down year-over-year due to lower volumes [20][22] Market Data and Key Metrics Changes - The market backdrop in the Lab segment is largely stable, but customer activity remains lower than expected due to ongoing end market uncertainty [16][22] - The company expects full-year organic revenue growth of negative 3.5% to negative 2.5%, with reported revenue growth anticipated at negative 4% to negative 3% [22][23] - The U.S. Federal government shutdown is expected to impact the Lab Solutions segment, contributing to reduced guidance [23][84] Company Strategy and Development Direction - The company is initiating a revival plan focusing on five key pillars: go-to-market strategy, strategic investments in manufacturing and supply chain, portfolio scrutiny, cost savings, and talent improvement [27][30] - A $500 million share repurchase program has been authorized to demonstrate confidence in the company's long-term value [12][72] - The management aims to simplify operations and empower frontline staff to better meet customer needs [11][30] Management's Comments on Operating Environment and Future Outlook - Management expressed disappointment with current results but emphasized confidence in the fixability of the issues faced [27][38] - The company is committed to improving operational execution and addressing competitive pressures [18][22] - Future performance is expected to improve as the revival plan is implemented, although it will take time to see significant results [33][72] Other Important Information - The company is focused on enhancing its e-commerce platform and improving service levels to regain market share [45][48] - A new Chief Operating Officer and other key leadership positions are being recruited to drive operational excellence [32][65] Q&A Session Summary Question: What is the confidence that the current declines are fixable? - Management expressed confidence that the issues are fixable, emphasizing the need for better communication and execution [36][38] Question: Can the business grow in 2026? - Management is taking a fresh look at the numbers and will provide clarity on growth expectations for 2026 after further analysis [39][40] Question: How to stem the tide of share loss? - Management acknowledged share losses but noted improvements in retaining key accounts and plans to enhance e-commerce capabilities [42][44] Question: What are the steps to address operational complexity? - Management plans to decentralize decision-making and empower local teams to improve customer engagement [46][47] Question: What is the rationale for the share buyback program? - The buyback program is intended to demonstrate confidence in the company's long-term value and commitment to turnaround efforts [71][72] Question: What are the expectations for the academic and government market? - The academic and government market is expected to remain challenged due to the government shutdown and other factors impacting consumables [84]

Financial Data and Key Metrics Changes - The company reported second quarter revenue of $1.68 billion, flat year-over-year on an organic basis [19] - Adjusted EBITDA margin contracted to 16.6%, with adjusted EPS for the quarter at $0.24, reflecting a year-over-year decline of $0.01 [8][21] - Free cash flow was $125 million, with adjusted conversion at 100% [8][21] - The company remains on track with its cost transformation program, expecting $400 million in run rate savings by 2027 [8] Business Line Data and Key Metrics Changes - Laboratory Solutions, which constitutes roughly two-thirds of the business, saw organic revenue growth in line with expectations, increasing sequentially compared to Q1 but finishing modestly down year-over-year [8][22] - Bioscience production revenue was $561 million, up 2% organically year-over-year and up 7% sequentially, with bioprocessing performance flat year-over-year due to customer headwinds [24][26] Market Data and Key Metrics Changes - The European business in Laboratory Solutions was nearly flat, outperforming The Americas and Asia, which faced greater policy headwinds [22] - The company experienced significant contract extensions with several top global pharma accounts, expected to yield over $100 million in share gains once fully commercialized [12] Company Strategy and Development Direction - The company is focused on executing strategic initiatives to drive growth, improve operating efficiency, and deliver long-term value despite ongoing challenges in the operating environment [7][32] - The leadership transition to Emanuel Ligner as the new CEO is expected to bring additional expertise, particularly in bioprocessing [6][104] Management's Comments on Operating Environment and Future Outlook - Management acknowledged ongoing competitive intensity and the need to protect and grow market share while preserving profitability [13][32] - The full-year organic revenue growth expectation has been reduced to negative 2% to flat, reflecting current trends and headwinds [27][28] Other Important Information - The company is implementing several digital initiatives to enhance customer experience, including the Avantor Navigator AI application and a new digital buying experience platform [11] - Adjusted EBITDA margin expectations have been updated to between 16.5% and 17% for the full year [30] Q&A Session Summary Question: Guidance for third quarter organic growth - Management indicated that the guidance reflects consistency in performance across segments, with some seasonality and timing issues impacting bioprocessing [36][37] Question: Impact of pricing and mix on margins - The decline in EBITDA margins was attributed primarily to pricing actions and mix, particularly in the lab business [38][39] Question: Long-term growth outlook for bioprocessing - Management remains confident in the long-term growth potential of bioprocessing, despite recent headwinds, citing strong demand for the monoclonal antibody platform [44][45] Question: Free cash flow reduction and contract dynamics - The reduction in free cash flow guidance is linked to significant contract extensions that involve upfront rebate payments [86][87] Question: Customer-specific challenges in bioprocessing - Management acknowledged unexpected customer headwinds impacting bioprocessing performance, but emphasized the overall strength of the platform and ongoing recovery in the end market [100][101]