Core Viewpoint - The article discusses the development of body fluid-triggered adhesive hydrogels that can rapidly seal wounds and promote tissue regeneration, presenting a promising alternative to traditional sutures in emergency medical situations [1][2][4]. Group 1: Research Development - The research team developed a body fluid-triggered adhesive hydrogel (BTTA) that can quickly seal wounds in the femoral artery and heart, demonstrating hemostatic effectiveness and clinical feasibility in human patients [2][4]. - The hydrogel can also rapidly seal lung wounds, preventing air leakage and bleeding while promoting the regeneration of alveoli in lung tissue [5][6]. Group 2: Mechanism and Performance - The BTTA hydrogel utilizes temporary phase separation to overcome the impact of body fluids on adhesion, allowing adhesive molecules to form covalent bonds directly with tissue surfaces [4][6]. - Experimental results indicate that the hydrogel can achieve hemostasis within 30 seconds for severe bleeding caused by femoral artery transection in large animals, with further validation in human patients undergoing aortic anastomosis [4][6]. Group 3: Advantages Over Existing Products - The hydrogel addresses the shortcomings of existing sealing agents by providing a new approach for rapid wound closure and tissue regeneration, particularly in complex wound scenarios [5][6].