Group 1 - HPV infection is a significant global public health issue, and the HPV vaccine is a crucial component of public health systems, especially with the promotion of strategies like the "Global Strategy to Accelerate the Elimination of Cervical Cancer" and "Healthy China Strategy" [1] - The introduction of domestic nine-valent HPV vaccines has sparked discussions on how to choose the best vaccine, highlighting the decision-making challenges faced by consumers [1] - Merck holds a leading position in the HPV vaccine market with its Gardasil®9, the only nine-valent vaccine approved for preventing cervical cancer caused by seven high-risk HPV types, and it is also the first and only nine-valent HPV vaccine approved for both males and females in China [1] Group 2 - Merck has a long history in vaccine development, having established itself as a key player in the global vaccine field since its founding in 1891, with significant contributions such as the transfer of hepatitis B vaccine technology to China [2] - The development of the HPV vaccine by Merck is rooted in a commitment to preventive medicine, emphasizing the importance of long-term efforts to ensure the vaccine's effectiveness over time [2] - The research and development of the HPV vaccine also benefited from Chinese scientific advancements, particularly the breakthroughs achieved by Chinese scientist Dr. Zhou Jian in the 1990s [2] Group 3 - As of May 2025, Merck's nine-valent HPV vaccine has been administered over 400 million doses globally, covering 112 countries, and has protected over 33 million eligible women in China since its approval in 2018 [3] - Long-term monitoring in countries like Australia has shown significant reductions in the incidence of HPV-related diseases following the implementation of vaccination programs, reinforcing the vaccine's effectiveness [3] - The stability of safety and efficacy data across different regions and time periods is a critical factor for healthcare providers and parents when choosing vaccines [3] Group 4 - Merck's Gardasil®9 utilizes a more mature yeast expression system, which enhances immunogenicity and reduces contamination risks, providing dual assurance of safety and efficacy [4] - The HPV vaccine market is transitioning from a "single supply" to "multiple competition," with Merck leveraging its extensive clinical data and global experience to offer reliable options for diverse consumer needs [4]