Core Viewpoint - The research team led by Professor Zhang Hongwei from Capital Medical University Sanbo Brain Hospital demonstrates the safety of oncolytic virus therapy and introduces an innovative "cystic channel" treatment approach to alleviate patient suffering and treatment burden [1] Group 1: Oncolytic Virus Therapy - Oncolytic virus therapy faces challenges as the immune system often eliminates the virus as a foreign entity, significantly shortening its effective attack period on tumors [1] - Clinical practice typically requires repeated administration to ensure therapeutic efficacy, which can be burdensome for patients [1] Group 2: Cystic Channel Treatment Approach - The traditional method of administering oncolytic virus therapy involves puncture injections into the brain, leading to additional brain damage and requiring separate surgical procedures for each injection [1] - The innovative "cystic channel" treatment allows for a single surgical procedure to place a small cyst under the patient's skin, connecting it to the tumor via a tube [1] - Subsequent administrations of the oncolytic virus can be done by injecting the drug into the cyst, which then delivers it directly to the tumor, minimizing repeated brain punctures and reducing the number of surgeries required, thus significantly alleviating the treatment burden on patients [1]