Core Insights - The article discusses the emerging technology of proximity labeling, which allows for precise and controllable chemical reactions in complex biological systems, addressing a significant challenge in chemical biology [2] - A recent study published in Nature introduces a novel approach to tumor immunotherapy using proximity labeling to construct artificial antigens, enhancing immune responses against tumors [3][9] Group 1: Proximity Labeling Technology - Proximity labeling has been widely adopted in laboratories over the past decade as a tool to reveal biological processes, but its potential applications beyond biotin substrates remain underexplored [2] - The study proposes the concept of using proximity labeling reactions to construct artificial antigens specifically in tumor tissues, aiming to improve immunotherapy outcomes [7] Group 2: PATCH Technology - The research team developed a technique called Proximity Amplification and Tagging of Cytotoxic Haptens (PATCH), which utilizes engineered nanoenzymes activated by red light or ultrasound to catalyze reactions on tumor cell surfaces [3][7] - This method allows for the rapid and covalent attachment of artificial antigens to nearby proteins on cancer cells, creating high-density antigen clusters that serve as "super beacons" for immune cells [9] Group 3: Efficacy and Safety - In multiple mouse tumor models, PATCH therapy demonstrated the ability to quickly and safely eliminate existing tumors while also inducing systemic immune activation and long-term immune memory [9][10] - The technology addresses two major challenges in current CAR-T and antibody therapies: the heterogeneity of tumor antigens and the potential toxicity to healthy tissues, by ensuring that reactions occur selectively at the tumor site [6][10] Group 4: Future Directions - The research team plans to explore the translational applications of this technology further, including testing its potential in recruiting other types of immune cells and expanding its use in various diseases such as organ aging and autoimmune disorders [10]