Group 1 - The study indicates that for low-risk acute ischemic stroke (AIS) patients, reducing the traditional monitoring frequency from 37 to 17 times within 24 hours is both safe and effective, optimizing medical resource allocation [1][3] - The research involved a collaboration among teams from Fudan University, Johns Hopkins University, and other institutions, covering 4,922 patients across 114 hospitals in 8 countries [1][2] - The findings were published in The Lancet, highlighting the results of the OPTIMISTmain trial, which focuses on monitoring frequency after venous thrombolysis for brain infarction [1][2] Group 2 - Acute stroke is the second leading cause of death and the third leading cause of disability globally, making stroke prevention and treatment a public health priority [2] - The traditional monitoring protocol, established in the 1990s, is resource-intensive and can interfere with patient rest and nursing staff's ability to provide education and support [2][3] - The study found no significant differences in key outcomes such as 90-day poor prognosis, incidence of brain hemorrhage, and serious adverse events between the two monitoring groups [3] Group 3 - The implementation of low-intensity monitoring led to a 30% reduction in ICU admission rates in U.S. hospitals, alleviating pressure on nursing resources [3] - The research team recommends incorporating the low-intensity monitoring protocol for low-risk patients into clinical guidelines to benefit more healthcare systems and patients [3] - Future research includes the establishment of a global research collaboration platform called "ACT-GLOBAL," aiming to enhance clinical trial efficiency by 40% and reduce research cycles by 30% [4]