最新研究：纳米技术研发新型抗蛇毒血清在小鼠实验中展现治疗前景 中新网北京11月3日电 (记者 孙自法)国际知名学术期刊《自然》最新发表一篇生物学论文称，利用纳米 技术研发、能抵抗某些非洲最致命毒蛇类(包括曼巴蛇、眼镜蛇和唾蛇)的一种实验性重组抗蛇毒血清， 已在小鼠实验中展现出治疗前景。 莫桑比克射毒眼镜蛇(图片来自Wolfgang Wüster)。施普林格·自然 供图 这项新型抗蛇毒血清的研发成果，或为蛇咬伤受害者开发出更安全和有效的治疗方法。 与东部绿曼巴蛇的近距离对视(图片来自Wolfgang Wüster)。施普林格·自然 供图 在本项研究中，论文共同通讯作者、丹麦技术大学Andreas H. Laustsen和同事及合作者一起，通过组合 名为纳米抗体的工程改造蛋白，创造出一种新型抗蛇毒血清，这些纳米抗体能靶向蛇毒中发现的关键毒 素。在用眼镜蛇、曼巴蛇和唾蛇等18种非洲蛇的毒液给一只羊驼和一只美洲驼进行免疫接种后，他们鉴 定出这些纳米抗体。在小鼠实验中，这种抗蛇毒血清能防止其中17种蛇的蛇咬伤导致的死亡，并缓解一 些最有害毒液导致的组织损伤。 论文作者指出，相比现有的一种商业抗蛇毒血清，这种基于纳米抗体 ...

Core Insights - The article highlights the remarkable journey of Tim Friede, who has survived 202 snake bites and self-administered over 800 doses of snake venom, ultimately contributing to the development of a new type of antivenom [1][3][12]. Group 1: Background and Motivation - Tim Friede developed an interest in snakes from a young age, leading him to experiment with self-immunization against snake venom [3][5]. - Self-immunization involves gradually exposing the body to harmful substances to build immunity, similar to vaccination [3][6]. Group 2: Research and Development - After a near-fatal incident in 2001, Friede intensified his self-immunization efforts, injecting venom from various snake species over 18 years [6][12]. - Immunologist Jacob Glanville, CEO of Centivax, sought Friede's blood for research to create a universal antivenom that could counteract multiple snake venoms [11][12]. Group 3: Scientific Breakthrough - In May 2025, Glanville's team published findings in the journal Cell, identifying two broad-spectrum human antibodies from Friede's blood that target common snake venom toxins [11][12]. - The new antivenom formulation showed promising results in mice, allowing survival against 13 out of 19 lethal snake venoms tested, potentially reducing treatment costs and saving lives [12][13].