Core Insights - A team from Beihang University has developed a flexible implantable bioelectronic device called POCKET, which allows for personalized drug delivery and gene transfection by conforming to the complex shapes of organs [1][2] - The device addresses a significant clinical issue regarding hereditary ovarian gene mutations, providing a safer alternative to traditional gene therapy methods that pose risks to sensitive organs [1][2] Group 1 - The POCKET device utilizes electroporation, a physical method that opens cell membranes using electric fields, overcoming limitations of traditional devices that cannot conform to the irregular surfaces of organs [2] - The research team introduced the "organ-customized paper-cut conformal theory," establishing a quantitative relationship between geometric parameters and organ curvature, enabling the design of highly conformal patches for various organs [2] - The device has been validated in multiple animal models and ex vivo human tissues, offering a new tool for precise treatment of ovarian cancer prevention and organ damage repair [2] Group 2 - A high-tech company has been established based on this core technology, having completed multiple rounds of financing [3] - The first product, "Ultra-NEP," has been applied in the field of skin health, with plans to expand its applications in medical-grade devices [3]