Core Viewpoint - The research presents a promising alternative strategy for thrombosis prevention through the development of a nanoscavenger that protects vascular endothelial cells from oxidative stress, addressing the bleeding risks associated with current antiplatelet therapies [5][9]. Group 1: Research Development - A novel reactive oxygen species (ROS) chemotactic nanoscavenger (MDCP) was developed, made from melanin and catalase, to prevent acute thrombosis by protecting endothelial cells [4][7]. - The study demonstrated that pre-injected MDCP can specifically accumulate in damaged blood vessels and effectively clear excess hydrogen peroxide while catalyzing the decomposition of superoxide radicals [7]. Group 2: Mechanism of Action - The MDCP enhances the synthesis of antioxidant metabolites involved in nitric oxide (NO) and glutathione production while reducing the release of inflammatory factors, thereby increasing endothelial cell resistance to ROS-induced apoptosis [7]. - This mechanism helps maintain endothelial integrity, preventing collagen exposure and subsequent platelet activation and thrombosis, with minimal impact on platelet function [9].