Core Insights - The article discusses the rational design of materials for uranium extraction from seawater, highlighting the potential of utilizing abundant uranium resources in seawater for sustainable nuclear fuel supply [2][4]. Group 1: Challenges and Opportunities - The extraction of uranium from seawater faces significant challenges, including low uranium concentration, the presence of competing ions, and harsh marine environments [4]. - Recent research indicates that precise control over surface chemistry and local structural environments is crucial for enhancing the selectivity and overall extraction capacity of uranium adsorbents [5]. Group 2: Design Strategies - The article summarizes rational design strategies aimed at improving uranium extraction efficiency, emphasizing emerging methods such as optimizing uranium adsorbents and incorporating catalysts to enhance uranium concentration [5][6]. - These strategies aim to improve the structural responsiveness and extraction behavior of materials in marine environments by increasing the exposure of active sites, reducing electrostatic repulsion, and facilitating mass transport [5]. Group 3: Future Directions - The article outlines recent advancements and emerging challenges in the field, proposing future research directions to accelerate the rational design and development of materials for uranium extraction from seawater [6]. - A design framework focusing on precise control of uranium binding sites, structural optimization, catalytic enhancement, and integration of anti-biofouling components is presented, offering new design concepts and directions for practical applications in natural seawater environments [6].