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大连理工薛闯教授:细胞工厂设计与产物合成强化
Core Insights - The article emphasizes the importance of strains as the "chip" of biomass refining, highlighting their role in the new bio-manufacturing industry chain and green low-carbon bio-economy [2] - It discusses the challenges faced by strain cells in bio-manufacturing, such as the accumulation of intermediate metabolites and the inhibition of toxic products, which lead to low reaction efficiency and product concentration [2] - The article outlines key research areas, including the construction of strain cell factories and the enhancement of product synthesis processes [2] Research and Development - The research led by Professor Xue Chuang from Dalian University of Technology focuses on creating artificial organelles using multi-enzyme self-assembled protein cages, which enhance the tunability of organelles through chemical and light induction [2] - A rapid strain construction method called "multi-gun-multi-target" has been developed, revealing new mechanisms for the multidimensional cooperative regulation of strains [2] - The team has also prepared carbon nanotube array composite membranes and developed reaction separation coupling technology, providing breakthroughs in enhancing bio-synthesis of bioenergy-based products [2] Conference Participation - Professor Xue Chuang will present at the SynBioCon 2025 conference, focusing on "Cell Factory Design and Product Synthesis Enhancement" [3] - The conference will take place from August 20-22, 2025, in Ningbo, Zhejiang, and will cover topics related to AI and bio-manufacturing, green chemicals, new materials, future food, and agriculture [14][15]