Core Viewpoint - The establishment of the Life Sciences Open Alliance aims to promote the integration of technological and industrial innovation in the life sciences sector, enhancing collaboration among high-level universities and research institutions in mainland China and Hong Kong-Macau to address global challenges such as human health, food crises, and extreme weather [1][2]. Group 1 - The alliance was launched on August 12, involving 15 universities and research institutions from mainland China and Hong Kong-Macau, including notable institutions like Peking University, Tsinghua University, and the University of Hong Kong [1]. - The alliance's objectives include fostering international collaboration in talent cultivation, technological innovation paradigm shifts, and the transformation of research outcomes [1][2]. - The alliance aims to create a global innovation network and a hub for talent development in the life sciences field [1]. Group 2 - The alliance plans to develop a series of high-level journals in the life sciences, with the main journal "Vita" being led by West Lake University and published by the Higher Education Press [2]. - It will establish an international open ecosystem for research data, addressing compliance and usability issues, and creating a high-quality data open platform [2]. - The alliance will leverage the advantages of the Guangdong-Hong Kong-Macau Greater Bay Area to accelerate technology transfer and transformation mechanisms between mainland and Hong Kong-Macau [2].