Core Insights - Defence Therapeutics Inc. has established its inaugural Scientific Advisory Board (SAB) to enhance its Accum®-Antibody drug conjugate (ADC) program, which has shown significant laboratory validation results [2][3][9] Group 1: Scientific Advisory Board Formation - The SAB consists of experts Rob Leanna, Danny Chui, and Brendan Hussey, who will provide scientific, technical, and strategic guidance for the company's programs [2][4] - The formation of the SAB aims to strengthen Defence's scientific foundation and support disciplined decision-making as the company advances its Accum® platform [9] Group 2: Accum®-Antibody Drug Conjugate Program - Defence's Accum®-ADC program has achieved laboratory validations, indicating a notable increase in intracellular accumulation and improved efficacy [3] - The SAB will help shape the direction and scientific priorities of the Accum®-enabled ADC programs as they progress towards clinical development [3][9] Group 3: Expertise of SAB Members - Rob Leanna brings extensive experience in ADC and drug-linker chemistry, having previously led development and regulatory strategy at AbbVie Inc. [5] - Danny Chui has over 20 years of experience in therapeutic antibody discovery and ADC development, contributing expertise in antibody engineering and preclinical pharmacology [6] - Brendan Hussey, with a background in biotechnology and investment banking, will align Defence's platform with market opportunities and partner expectations [7] Group 4: Company Overview - Defence Therapeutics is focused on engineering next-generation ADC products using its proprietary Accum® technology, which enhances the precision delivery of biologics [10] - The Accum® platform aims to improve efficacy and potency for biologics, thereby expanding patient access and market opportunities [10]

Core Insights - Defence Therapeutics Inc. has announced promising preclinical in vivo results for its Accum®-Kadcyla, a novel version of Kadcyla® targeting HER2-positive breast cancer, showcasing a significant increase in anti-tumor efficacy [1][2][5] Study Results - Accum®-Kadcyla exhibited approximately a 20-fold increase in anti-tumor efficacy compared to Kadcyla® when administered at the same dose of 0.5 mg/kg, with significant tumor growth inhibition observed [2] - The study reported a durable and near-complete response in most mice treated with Accum®-Kadcyla, while Kadcyla® showed no effect at the same dosage [2] - All animals in the Accum®-Kadcyla group survived the study duration without signs of toxicity, indicating excellent tolerability [2] Implications for Patients and the Industry - The enhanced efficacy at lower doses could lead to reduced toxicity and side effects, addressing a major limitation of current ADC therapies, potentially allowing for a shift from second-line to first-line treatment options for patients [5][6] - The results validate the Accum® platform's ability to improve intracellular delivery and potency of ADCs by overcoming endosomal entrapment, thus enabling more efficient drug release and tumor killing [5][6] Next Steps and Commercial Outlook - Following these results, Defence Therapeutics plans to expand its Accum®-ADC program to additional HER2-positive and HER2-low tumor models and engage in discussions with potential pharmaceutical partners [7]

Core Insights - Defence Therapeutics Inc. is advancing its Accum® platform, which enhances the delivery of antibody-drug conjugates (ADCs) for cancer treatment, potentially transforming precision oncology [1][4][5] Company Overview - Defence Therapeutics is a clinical-stage biotechnology company focused on developing next-generation ADC products using its proprietary Accum® technology, which allows for precision delivery of ADCs to target cells [9] Technology and Innovation - The Accum® platform provides "laser-guided precision" in delivering drugs inside cancer cells, improving payload efficiency and reducing toxic side effects [2][3] - The analogy used illustrates that while traditional methods send many soldiers (drugs) to target a cancer cell, Accum® allows for a more effective approach with fewer drugs achieving the desired effect [3] Market Potential - ADCs are among the most effective anti-cancer drugs, but their use has been limited due to dose-limiting toxicity; Accum® may enable their application as first-line therapies [3][4] - Defence plans to partner with existing ADC developers and expand the applications of Accum® to novel therapies, indicating a strong near-term revenue outlook [4][5] Intellectual Property Strategy - The company employs a "picket fence" approach to protect its intellectual property portfolio globally, covering multiple aspects of the delivery platform [4]