Pipeline Programs - Setrusumab for Osteogenesis Imperfecta (OI) Phase 3 results were reported around the end of 2025, partnered with Ultragenyx, but neither study achieved the primary endpoint of reduction in AFR compared to placebo or bisphosphonates[8, 11] - Alvelestat for Alpha-1 Antitrypsin Deficiency-associated Lung Disease (AATD-LD) activities are ongoing to support the initiation of Phase 3, following an agreement in principle on the primary endpoints[8] - Vantictumab for osteopetrosis is out-licensed to āshibio, with EU rights retained, and an IND is planned for H2 2026[8] Financial Status - The company has approximately $41 million in cash and cash equivalents as of December 31, 2025, providing a cash runway into mid-2027[8] Setrusumab Clinical Trial Results - In the Orbit study (Setrusumab vs placebo), 19.5% of patients met rescue criteria at 12 months, primarily due to fractures, with a larger number of placebo patients exiting the study[14] - In the Cosmic study (Setrusumab vs bisphosphonates), there was a 59% reduction in vertebral fractures on setrusumab (p=0.081), despite more severe type III/IV patients on setrusumab (65% setrusumab vs 54% IV-BP)[31] - Setrusumab patients in the Orbit study showed improvements in disease severity (PGIS) in peds/teens, as well as improvements in pain/comfort and sports/activity[20] Market Opportunities - Osteogenesis Imperfecta affects approximately 60,000 patients across the US & Europe[9] - Severe Alpha-1 Antitrypsin Deficiency affects an estimated 50,000 patients in North America and 60,000 in Europe[9] - Osteopetrosis has an incidence of 1 in 20,000 in North America and Europe, with onset typically in late childhood[9]

Core Viewpoint - Stocks priced under $10 offer an attractive entry point for investors looking to diversify their portfolios and maximize growth potential without significant capital outlay [1] Group 1: Ford Motor Company - Ford Motor Company is currently trading at $9.98 with a dividend yield of 6.02% and a P/E ratio of 6.83, indicating strong value [2][3] - The company reported record revenue of $185 billion for the full year of 2024 and has a positive outlook for 2025, with significant investments in electric vehicle (EV) infrastructure totaling up to $50 billion by 2026 [3] - Ford aims to achieve 2 million annual EV sales by 2026 while maintaining its internal combustion engine vehicle business [3] Group 2: Nokia Oyj - Nokia Oyj is trading at $5.14 with a dividend yield of 1.55% and a P/E ratio of 20.58, positioning it as a key player in telecommunications [5] - The company exceeded Q4 2024 earnings expectations and projects a Comparable Operating Profit between $2.1 billion and $2.7 billion for 2025, alongside strong free cash flow [6] - Nokia's leadership in 5G infrastructure and expansion into high-growth markets like data center networking enhances its revenue diversification [7] Group 3: Goodyear Tire & Rubber Company - Goodyear is currently priced at $9.67 with a P/E ratio of 40.29, indicating potential undervaluation [8][9] - The company reported a full-year 2024 segment operating income of $1.318 billion, reflecting a $350 million year-over-year increase, driven by its "Goodyear Forward" transformation plan [11] - Goodyear aims to achieve $1.5 billion in annual run-rate benefits by the end of 2025 through cost reductions and margin expansion [10] Group 4: Standard Lithium Ltd. - Standard Lithium is trading at $1.23 with a P/E ratio of 2.08, representing a high-risk, high-reward investment opportunity in the EV battery supply chain [12] - The company focuses on innovative Direct Lithium Extraction technology and has received a conditional $225 million grant from the U.S. Department of Energy for its South West Arkansas Project [14] - Standard Lithium's projects in Arkansas position it well to meet the surging demand for lithium in EV batteries [13] Group 5: Mereo BioPharma Group - Mereo BioPharma is priced at $2.45 and focuses on developing drug candidates for rare diseases, presenting a high-risk, high-reward investment opportunity [15] - The company's pipeline includes late-stage candidates Setrusumab and Alvelestat, with Setrusumab receiving Breakthrough Therapy Designation from the U.S. FDA [16] - Mereo has a cash runway extending into 2027, providing financial stability for its clinical programs [17] Group 6: Investment Opportunities - The five identified companies, all priced under $10, present compelling investment opportunities for Q2 2025, with established firms like Ford and Goodyear offering potential value and dividends, while Nokia, Standard Lithium, and Mereo BioPharma represent higher-risk, higher-reward prospects [18]