Dianthus Therapeutics Conference Call Summary Company Overview - **Company**: Dianthus Therapeutics (NasdaqCM:DNTH) - **Date**: October 16, 2025 - **Focus**: Development of next-generation therapeutics for autoimmune diseases Key Points Industry and Product Development - Dianthus announced an exclusive license agreement with Nanjing Leads Biolabs for **DNTH212**, a bifunctional BDCA2 and BAFF-APRIL inhibitor, which is phase 1-ready [2][3] - The agreement grants Dianthus global rights outside of Greater China for DNTH212, enhancing its position in autoimmune therapeutics [3][4] - DNTH212 is designed to target both the innate and adaptive immune systems, potentially offering enhanced efficacy for autoimmune diseases [4][6] Clinical Data and Mechanism of Action - Favorable clinical data from previous therapies (Lidofilumab and POVITAF-SET) support the efficacy of DNTH212 [4][8] - DNTH212 has shown superior in vitro inhibition of plasmacytoid dendritic cells (PDCs) and immunoglobulin reductions in non-human primates (NHPs) compared to existing therapies [4][8] - The drug is expected to have a convenient dosing regimen, potentially allowing for subcutaneous self-administration every four weeks or less [4][5] Financial and Strategic Position - Following the transaction, Dianthus estimates a pro forma cash balance of approximately **$525 million**, providing a cash runway into 2028 [5][12] - The transaction includes an upfront payment of **$30 million** and potential milestone payments totaling up to **$962 million** based on development and sales success [11][12] Future Expectations and Trials - A phase 1 trial for DNTH212 is expected to begin in Q4 2025, with results anticipated in the second half of 2026 [5][16] - The company plans to announce prioritized indications for DNTH212 in 2026, focusing on conditions where type I interferon and B cells are implicated [13][16] Collaboration and Market Position - The partnership with Nanjing Leads Biolabs is viewed as a strong collaboration, allowing for data sharing and joint development efforts [43][44] - Dianthus aims to leverage its expertise and the collaboration to maximize the potential of DNTH212 across various autoimmune indications [51][53] Competitive Landscape - There are currently no known competing BDCA2 and BAFF-APRIL inhibitors in development, positioning DNTH212 uniquely in the market [59][60] - The company emphasizes the scientific rationale behind targeting both pathways, which has been well-received by key opinion leaders in rheumatology [60][62] Conclusion - Dianthus Therapeutics is poised to enhance its leadership in autoimmune therapeutics with DNTH212, which is expected to deliver superior efficacy and patient-friendly administration [14][65] - The company is committed to advancing its pipeline and addressing significant unmet needs in the autoimmune disease space [65]