Core Viewpoint - Coherus Oncology, Inc. has successfully closed a public offering of 28,600,000 shares at a price of $1.75 per share, raising approximately $50.1 million to support its clinical development and commercialization efforts [1][3][4]. Group 1: Offering Details - The public offering was led by healthcare-focused investors including Janus Henderson Investors, HBM Healthcare Investments, and Samsara BioCapital [2]. - The gross proceeds from the offering were approximately $50.1 million, with a 30-day option for underwriters to purchase an additional 4,290,000 shares [1][4]. - The offering was conducted under an effective shelf registration statement previously filed with the SEC [5]. Group 2: Company Strategy and Use of Proceeds - Coherus aims to utilize the net proceeds from the offering to support the commercialization of LOQTORZI (toripalimab-tpzi), continue clinical development of its product candidates, and for general corporate purposes [4]. - The company has significantly improved its financial position by reducing debt by over 80% and transitioning from a biosimilar company to a clinical-stage biotech focused on innovative oncology [3]. Group 3: Product Pipeline - Coherus has an approved next-generation PD-1 inhibitor, LOQTORZI, and a pipeline that includes mid-stage clinical candidates targeting various cancers [7]. - The innovative oncology pipeline includes multiple antibody immunotherapy candidates designed to enhance immune responses against tumors [8].

Core Viewpoint - Coherus Oncology, Inc. has announced a public offering of 28,600,000 shares of common stock at a price of $1.75 per share, aiming to raise approximately $50.1 million in gross proceeds before expenses [1][2]. Group 1: Offering Details - The public offering price is set at $1.75 per share, with gross proceeds expected to be around $50.1 million before underwriting discounts and commissions [1]. - The company has granted underwriters a 30-day option to purchase an additional 4,290,000 shares at the public offering price [1]. - The offering is anticipated to close on or about February 17, 2026, pending customary closing conditions [1]. Group 2: Use of Proceeds - Coherus plans to utilize the net proceeds from the offering to support the commercialization of LOQTORZI (toripalimab-tpzi), continue clinical development of its product candidates, and for working capital and other general corporate purposes [2]. Group 3: Company Overview - Coherus Oncology is a fully integrated commercial-stage innovative oncology company with an approved PD-1 inhibitor, LOQTORZI, and a pipeline that includes mid-stage clinical candidates targeting various cancers [5]. - The company's strategy focuses on growing sales of LOQTORZI in R/M nasopharyngeal carcinoma and advancing new indications in combination with its pipeline candidates and partners [5]. Group 4: Pipeline Information - Coherus' pipeline includes multiple antibody immunotherapy candidates aimed at enhancing immune responses to improve cancer treatment outcomes [6]. - Tagmokitug, a selective anti-CCR8 antibody, is currently in Phase 1b/2a studies for advanced solid tumors, while Casdozokitug, an IL-27 antagonistic antibody, is being evaluated in a Phase 2 study for first-line hepatocellular carcinoma [6].

Core Viewpoint - Coherus Oncology, Inc. has announced a proposed underwritten public offering of its common stock to support the commercialization of its product LOQTORZI and fund ongoing clinical development and general corporate purposes [1][2]. Group 1: Offering Details - The proposed offering includes a 30-day option for underwriters to purchase up to 15% additional shares at the public offering price [1]. - The offering is subject to market conditions, and there is no assurance regarding its completion or the actual size and terms [3]. Group 2: Use of Proceeds - The net proceeds from the offering will be utilized for the commercialization of LOQTORZI, continued clinical development of product candidates, and general corporate purposes [2]. Group 3: Company Overview - Coherus Oncology is a fully integrated commercial-stage oncology company with an approved PD-1 inhibitor, LOQTORZI, and a pipeline that includes mid-stage clinical candidates targeting various cancers [6]. - The company's strategy focuses on growing sales of LOQTORZI in nasopharyngeal carcinoma and advancing new indications in combination with pipeline candidates and partners [6]. Group 4: Pipeline Information - Coherus' pipeline includes multiple antibody immunotherapy candidates aimed at enhancing immune responses against cancer [7]. - Tagmokitug is in Phase 1b/2a studies for advanced solid tumors, while Casdozokitug is being evaluated in a Phase 2 study for hepatocellular carcinoma [7].

Core Insights - The company is focused on transforming into an innovative oncology firm that aims to overcome immune resistance in cancer treatment [3] Company Progress - The CEO provided an update on the company's progress over the past 12 months since the last conference [2] - The cornerstone therapy for the company is LOQTORZI, which serves as a revenue multiplier in conjunction with their PD-1 backbone [3] Promising Assets - The company is developing Tagmokitug, a promising asset in the evolving class of Treg depleters, highlighting its mechanism of action and potential as a new treatment paradigm [3] - Casdozokitug was also mentioned as part of the company's portfolio, indicating ongoing development in innovative cancer therapies [3]

Coherus Oncology FY Conference Summary Company Overview - **Company**: Coherus Oncology (NasdaqGM:CHRS) - **Event**: FY Conference at the 44th JPMorgan Healthcare Conference - **Date**: January 13, 2026 Key Points Company Transformation and Strategy - Coherus has evolved into an innovative oncology company focused on overcoming immune resistance in cancer treatment, with Lactose as a cornerstone therapy [2][3] - The acquisition of Surface Oncology in September 2023 provided global rights to promising products CHS-114 (a CCR8 Treg depleter) and Casdozokitug [4] - The company divested its biosimilar business, raising approximately $800 million, which helped pay down $480 million in debt and support ongoing clinical studies [5] Product Pipeline and Market Opportunities - Coherus's pipeline represents a market opportunity of approximately $29 billion, with significant potential in both U.S. and ex-U.S. markets [9] - **Lactose**: A next-generation PD-1 therapy showing high activity, particularly in low PD-1 states, with a five-year survival rate improvement from 34 months to 65 months when combined with chemotherapy [11] - **CHS-114**: Positioned as a best-in-class Treg depleter, targeting Tregs in the tumor microenvironment to enhance T cell infiltration [15][16] - **Casdozokitug**: A first-in-class IL-27 antagonist showing a 38% overall response rate in hepatocellular carcinoma (HCC) studies, with ongoing trials expected to yield data in mid-2026 [24][25] Financial Projections and Sales Growth - Coherus anticipates revenue growth for Lactose, projecting $150-$200 million by mid-2028, supported by a strong sales trajectory and market penetration strategies [12][49] - The company has successfully increased demand growth quarter-over-quarter, exceeding initial guidance of 10%-15% [12] Clinical Trials and Data Expectations - Coherus is conducting multiple clinical trials across various cancers, with significant data readouts expected in 2026 [6][19] - The company is focused on optimizing dosing and understanding the best treatment settings for its products, particularly for Tecmo Kito and Casdozokitug [31][32] Competitive Landscape and Differentiation - Coherus emphasizes the selectivity and potency of its products, particularly Tecmo Kito, which is the only selective CCR8 binder disclosed, differentiating it from competitors [33][34] - The company is pursuing partnerships to enhance the development of its therapies, particularly in combination with other modalities like T-cell engagers and CAR-T therapies [40][41] Challenges and Market Dynamics - The company faces challenges in educating community physicians about its products due to the rarity of the diseases treated, necessitating sophisticated outreach strategies [48][49] - Coherus is aware of the competitive landscape and is strategically positioning its products to overcome resistance mechanisms in solid tumors [43] Future Outlook - Coherus is optimistic about 2026, with a strong focus on data generation and strategic partnerships to drive growth and enhance shareholder value [29][30] Conclusion Coherus Oncology is strategically positioned for growth in the oncology market with a robust pipeline and a focus on innovative therapies. The company is actively working to enhance its market presence and drive shareholder value through strategic partnerships and clinical advancements.

Core Insights - Coherus Oncology, Inc. will present at the 44th Annual J.P. Morgan Healthcare Conference on January 13, 2026, at 10:30 a.m. Pacific Time, with the presentation accessible via webcast [1] - The webcast will be available for replay until February 13, 2026 [2] Company Overview - Coherus Oncology is a fully integrated commercial-stage innovative oncology company with an approved next-generation PD-1 inhibitor, LOQTORZI® (toripalimab-tpzi), and a pipeline that includes two mid-stage clinical candidates targeting various cancers [3] - The company's strategy focuses on growing sales of LOQTORZI in nasopharyngeal carcinoma (NPC) and advancing new indications for LOQTORZI in combination with its pipeline candidates and partners [3] Pipeline Details - Coherus' oncology pipeline includes multiple antibody immunotherapy candidates aimed at enhancing immune responses to improve cancer treatment outcomes [4] - Tagmokitug, a selective cytolytic anti-CCR8 antibody, is currently in Phase 1b/2a studies for advanced solid tumors, including head and neck squamous cell carcinoma, colorectal cancer, gastric cancer, and esophageal cancer [4] - Casdozokitug, a novel IL-27 antagonistic antibody, is being evaluated in a Phase 2 study for first-line hepatocellular carcinoma [4]

Company Overview - Coherus Oncology is a fully integrated commercial-stage innovative oncology company with an approved next-generation PD-1 inhibitor, LOQTORZI (toripalimab-tpzi) [3] - The company has a pipeline that includes two mid-stage clinical candidates targeting various cancers such as liver, lung, head & neck, and colorectal [3] Upcoming Events - Senior management will present at the 44th Annual J.P. Morgan Healthcare Conference on January 13, 2026, at 10:30 a.m. Pacific Time [1] - The presentation and Q&A session will be accessible via webcast, available for replay until February 13, 2026 [1][2] Pipeline and Research - Coherus' innovative oncology pipeline includes multiple antibody immunotherapy candidates aimed at enhancing immune responses for better cancer treatment outcomes [4] - Tagmokitug, a highly selective cytolytic anti-CCR8 antibody, is currently in Phase 1b/2a studies for advanced solid tumors [4] - Casdozokitug, a novel IL-27 antagonistic antibody, is being evaluated in a Phase 2 study for first-line hepatocellular carcinoma [4]

Core Viewpoint - Coherus Oncology has introduced its investigational anti-CCR8 monoclonal antibody, tagmokitug, which shows high selectivity and efficacy in targeting CCR8+ T regulatory cells in solid tumors, indicating its potential as an anticancer treatment [1][3][4]. Group 1: Scientific Evidence and Mechanism - The publication in Molecular Cancer Therapeutics highlights tagmokitug's picomolar binding affinity and its ability to selectively eliminate CCR8+ T regulatory cells without off-target binding [1][3]. - Preclinical and clinical studies demonstrate that tagmokitug induces significant tumor regression in mouse models, especially when combined with anti-PD-1 antibody treatment [4]. - The first-in-human clinical study confirms that tagmokitug leads to selective reductions in CCR8+ Tregs in cancer patients, establishing proof of mechanism [5]. Group 2: Clinical Development and Pipeline - Tagmokitug is currently undergoing Phase 1b/2a clinical trials in combination with the PD-1 inhibitor toripalimab and chemotherapy for patients with various solid tumors [6][8]. - Coherus Oncology's pipeline includes multiple antibody immunotherapy candidates aimed at enhancing immune responses to improve cancer treatment outcomes [8]. Group 3: Company Overview - Coherus Oncology is a commercial-stage innovative oncology company with an approved PD-1 inhibitor, LOQTORZI®, and a promising pipeline targeting various cancers [7]. - The company's strategy focuses on growing sales of LOQTORZI in nasopharyngeal carcinoma and advancing new indications in combination with its pipeline candidates [7].

Core Insights - Coherus Oncology's CHS-114 shows promising results in selectively depleting CCR8+ Tregs and enhancing immune response in patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) [1][2][3] Clinical Trial Results - The Phase 1b clinical trial of CHS-114 demonstrated a greater than 50% increase in intratumoral CD8 T cells, indicating a shift towards a "hot" tumor microenvironment [1][2] - CHS-114 treatment resulted in a 74% reduction in CCR8+ Treg density and a 73% increase in CD8+ T cell density, showcasing effective immune remodeling [5][6] Safety and Efficacy - The combination of CHS-114 with toripalimab has shown a manageable safety profile and early signs of antitumor activity in HNSCC patients [2][3] - A partial response was observed in a refractory head and neck cancer patient during initial safety testing of the combination therapy [3] Development Strategy - The data supports advancing CHS-114 in combination with toripalimab or other immune activators, aligning with the company's development plan [3][4] - Ongoing enrollment in the dose optimization arm aims to address the FDA's Project Optimus and define a phase 2 dose for CHS-114 [3][7] Company Overview - Coherus Oncology is focused on developing innovative oncology therapies, including the next-generation PD-1 inhibitor LOQTORZI and CHS-114, targeting various cancers [9][10]

Core Insights - Coherus Oncology, Inc. will release its third quarter 2025 financial results on November 6, 2025, after market close [1] - A conference call and webcast will be held at 5:00 p.m. Eastern Time on the same day to discuss the financial results and provide a business update [1][3] Company Overview - Coherus Oncology is a commercial-stage innovative oncology company with an approved PD-1 inhibitor, LOQTORZI® (toripalimab-tpzi), and a growing revenue stream [6] - The company has a promising pipeline that includes two mid-stage clinical candidates targeting various cancers such as liver, lung, and head & neck [6] Pipeline and Research - Coherus' pipeline features multiple antibody immunotherapy candidates aimed at enhancing immune responses against tumors [7] - CHS-114, a selective anti-CCR8 antibody, is currently in Phase 1b/2a studies for advanced solid tumors [7] - Casdozokitug, an IL-27 antagonistic antibody, is being evaluated in a Phase 2 study for first-line hepatocellular carcinoma [7]