Twist Bioscience (NasdaqGS:TWST) 2025 Conference November 17, 2025 03:20 PM ET Company ParticipantsAdam Laponis - CFOEmily Leproust - CEODoug Schenkel - Head of Life Science & Diagnostic ToolsDoug SchenkelAll right, good afternoon, everybody. This is Doug Schenkel from Wolfe Research. It's my pleasure to welcome Emily Leproust, Twist's CEO, and Adam Laponis, the company's Chief Financial Officer. Thanks to the two of you for being here. I know it was a quick turnaround with, it feels like it was a while ago ...

Twist Bioscience (NasdaqGS:TWST) 2025 Conference November 17, 2025 03:20 PM ET Company ParticipantsAdam Laponis - CFOEmily Leproust - CEOConference Call ParticipantsDoug Schenkel - AnalystDoug SchenkelAll right, good afternoon, everybody. This is Doug Schenkel from Wolfe Research. It's my pleasure to welcome Emily Leproust, Twist's CEO, and Adam Laponis, the company's Chief Financial Officer. Thanks to the two of you for being here. I know it was a quick turnaround with, it feels like it was a while ago, bu ...

Summary of London Stock Exchange Group (LSEG) Update / Briefing Company Overview - **Company**: London Stock Exchange Group (LSEG) - **Date of Briefing**: November 10, 2025 - **Focus**: Innovations, strategic transformation, and financial performance Key Points Industry and Market Position - LSEG operates in a competitive landscape, often ranking in the top three or number one in its markets [3][4] - The company serves non-discretionary functions for clients, indicating essential services [3] - Markets are projected to grow from mid-single digits to double digits, particularly in FTSE Russell and risk intelligence [4] Strategic Initiatives - LSEG has a partnership model based on an open ecosystem, emphasizing collaboration with customers [3] - The company is focused on integrating its various services to enhance customer experience, particularly through its data flywheel [5][6] - LSEG is aligned with long-term industry trends, including the growing demand for trusted data and the digitization of financial services [7][8] Financial Performance - Approximately 75% of LSEG's revenue comes from recurring subscription services, providing stability [9] - The company has achieved a 14% compound growth over the last four years, with earnings per share compounding at 15% over 20 years [10] - LSEG has returned $5 billion via buybacks in three and a half years, representing about 10% of its market capitalization [11] Transformation Journey - The acquisition of Refinitiv was a pivotal moment, transforming LSEG from a regional, equities-focused business to a global player with strong data capabilities [12][13] - The company has exceeded growth expectations post-acquisition, achieving over 6% growth annually [15] - LSEG has successfully realized synergies from the Refinitiv deal, exceeding initial targets for both revenue and cost synergies [16] Engineering and AI Strategy - LSEG is undergoing an engineering transformation to enhance product development and operational efficiency [31][32] - The AI strategy is built on three pillars: trusted data, transformative products, and intelligent enterprise [39][40] - LSEG's data is AI-ready, with 90% of data and feeds revenue based on proprietary data, which is not accessible to public AI models [42] Product Development and Innovation - The company is focused on continuous product innovation, with significant investments in platforms like Workspace and TradeWeb [25][26] - LSEG has launched numerous new products across all divisions in the last year, enhancing its service offerings [27] - The partnership with Microsoft is crucial for co-developing AI-driven products and improving customer experiences [66][69] Customer Engagement and Satisfaction - LSEG emphasizes customer partnerships and satisfaction, with a focus on reducing total cost of ownership for clients [24] - The company is actively working on integrating its data into various platforms, enhancing accessibility and usability for customers [50] Future Outlook - LSEG is committed to ongoing transformation and innovation, adapting to evolving technologies and regulatory changes [28] - The company aims to maintain its competitive edge by leveraging its unique data assets and strategic partnerships [66] Additional Important Insights - The leadership team has undergone significant changes to drive transformation, bringing in industry experts to enhance capabilities [19][20] - LSEG's diversified exposure across asset classes and geographies mitigates risks associated with market fluctuations [10][7] - The company is focused on building a product-led culture, ensuring that customer experience is at the forefront of its operations [38]

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Listing Announcement - BitMart 将独家首发上线 DNA (DNA) [1] - DNA 交易对为 DNA/USDT [1] - 存款已开放 [1] - 交易将于 2025 年 8 月 25 日 UTC 时间上午 9:00 开放 [1]

Listing Announcement - BitMart will list $DNA [1] - Follow social media for more announcements [1] Community Engagement - Encourage users to share their opinions about the project [1]

DNA Origami & Applications - DNA origami is the science of folding DNA into mechanisms and machines, utilizing DNA as a construction material at the nanoscale (1 billionth of a meter) [4][6] - Typical origami structures have dimensions of approximately 100 nanometers, smaller than the wavelength of visible light, making them suitable for investigating biological systems [7] - DNA origami leverages the ATCG binding rule to self-assemble structures from a long single-stranded DNA scaffold and shorter staple strands [11][13][14] - In 2006, Dr Paul Rothman introduced DNA origami, demonstrating the creation of shapes like stars and smiley faces [17] Research & Development - Research focuses on creating force sensors to measure forces in biological systems using DNA origami [18] - The creation of a DNA origami replica of the Ohio State marching band's Script Ohio, composed of 192 tokens, each representing a band member, earned a Guinness World Record [19][20][26] - The design process involves introducing stress into a straight rod of DNA origami by adding too much DNA in some spots and not enough in others, causing it to bend into the desired shape [23] Targeted Drug Delivery - Targeted drug delivery for cancer treatment is a key application, aiming to improve the precision of drug delivery to cancerous cells while minimizing harm to healthy cells [27][28] - A "Trojan horse" device, designed to be easily absorbed by cancerous cells, carries drugs directly to the nucleus, bypassing cellular defense mechanisms [28][29][30] - These structures can potentially recognize and attach to cancerous cells via unique genetic sequences (A's, T's, G's, and C's), ensuring targeted delivery [31][32] Educational Initiatives - Current research involves creating DNA origami experiments for middle school, high school, and undergraduate students, using readily available equipment [34]