Clinical data was reported for the first time in patients receiving an 8 mg dose per injection (Cohort 9 of the dose escalation portion of RESOLVE), the highest dose planned in this trial. Patients in Cohort 9 experienced the largest improvements in tissue health outcomes and eosinophil reduction observed to date.RESOLVE Safety Committee and members of the Eupraxia Clinical Advisory Board endorsed using the 8 mg dose per injection as the second dose for the ongoing Phase 2b portion of the RESOLVE study.Eupr ...

VICTORIA, British Columbia, Sept. 24, 2025 (GLOBE NEWSWIRE) -- Eupraxia Pharmaceuticals Inc. (“Eupraxia” or the “Company”) (NASDAQ:EPRX) (TSX:EPRX), a clinical-stage biotechnology company leveraging its proprietary Diffusphere™ technology designed to optimize local, controlled drug delivery for applications with significant unmet need, is pleased to announce the successful closing of its previously announced public offering (the "Offering") of 14,636,363 common shares of the Company (the “Common Shares"), w ...

Core Viewpoint - Eupraxia Pharmaceuticals Inc. has announced a public offering of 12,727,273 common shares at a price of US$5.50 per share, aiming to raise approximately US$70 million for advancing its product pipeline and other corporate purposes [1][3] Group 1: Offering Details - The offering consists of 12,727,273 common shares priced at US$5.50 each, with gross proceeds expected to be around US$70 million before expenses [1] - Underwriters have a 30-day option to purchase an additional 1,909,090 common shares under the same terms [1] - The offering is set to close on September 24, 2025, pending customary closing conditions [1] Group 2: Use of Proceeds - The net proceeds will primarily fund the advancement of the product pipeline, including ongoing preclinical studies, clinical trials, regulatory submissions, and commercial preparation [3] - Additional allocations will support research and development of new pipeline candidates, business development initiatives, and general corporate purposes [3] - The company may also invest in expanding its intellectual property portfolio and enhancing corporate infrastructure for future growth [3] Group 3: Regulatory and Compliance - The offering is made under a U.S. registration statement declared effective by the SEC and the existing Canadian short form base shelf prospectus [4] - A preliminary prospectus supplement has been filed with securities commissions in Canada and the SEC in the U.S., with a final supplement to follow [4][5]

Core Viewpoint - Eupraxia Pharmaceuticals Inc. has filed a preliminary prospectus supplement for a proposed public offering of common shares, aiming to leverage its proprietary Diffusphere™ technology for drug delivery [1][4]. Group 1: Offering Details - The company plans to grant underwriters a 30-day option to purchase up to an additional 15% of the common shares offered [2]. - The offering will be priced based on market conditions, with final terms to be determined at pricing [2]. - The closing of the offering is subject to customary conditions, including listing approvals from the TSX and Nasdaq [2]. Group 2: Use of Proceeds - Net proceeds from the offering will primarily support the advancement of the product pipeline, including preclinical studies, clinical trials, regulatory submissions, and commercial preparation [4]. - A portion of the proceeds will also be allocated to research and development of additional pipeline candidates, business development initiatives, and general corporate purposes [4]. - The company may use proceeds to expand its intellectual property portfolio and strengthen corporate infrastructure for future growth [4]. Group 3: Company Overview - Eupraxia is a clinical-stage biotechnology company focused on developing locally delivered, extended-release products for high unmet medical needs [7]. - The proprietary Diffusphere™ technology is designed to facilitate targeted drug delivery of both existing and novel drugs [7].

Core Insights - Eupraxia Pharmaceuticals announced positive clinical data from its Phase 1b/2a RESOLVE trial for EP-104GI, a treatment for eosinophilic esophagitis (EoE), showing promising results at 52 weeks post-treatment [1][2]. Clinical Trial Results - The RESOLVE trial demonstrated that patients receiving 4mg of EP-104GI showed clinical remission rates of 56% at Week 12, 78% at Week 24, 67% at Week 36, and 67% at Week 52 [3]. - Two-thirds of patients in the 48mg dose cohort maintained clinical remission after 12 months, indicating durable treatment effects [7]. - Improvements in tissue health were observed across all cohorts, with significant reductions in EoE Histological Scoring System (EoEHSS) scores, showing a 47% improvement in severity and a 44% improvement in extent at Week 36 [8]. Pharmacokinetics - Plasma levels of fluticasone in patients treated with 4mg of EP-104GI remained stable and predictable over 52 weeks, significantly lower than levels typically seen with daily asthma inhalers [9][11]. Market Potential - The treatment regimen for EP-104GI could align with the annual endoscopy routine for EoE patients, contrasting with current treatments that require daily or weekly administration [2]. - EoE affects over 450,000 individuals in the U.S., with increasing incidence and prevalence, highlighting a significant market opportunity for effective treatments [17]. Company Overview - Eupraxia Pharmaceuticals focuses on developing locally delivered, extended-release products targeting high unmet medical needs, utilizing its proprietary Diffusphere™ technology for optimized drug delivery [18][19].

Core Insights - Eupraxia Pharmaceuticals reported a net loss of $8.7 million for Q2 2025, an increase from a net loss of $6.1 million in Q2 2024, primarily due to rising research and development costs [4] - The company had cash reserves of $19.8 million as of June 30, 2025, down from $33.1 million at the end of Q4 2024, with expectations to fund operations into Q3 2026 [5][6] - The Phase 2b portion of the RESOLVE trial for EP-104GI has commenced, with topline data expected in the second half of 2026 [2][8] Financial Performance - The increase in net loss for Q2 2025 was attributed to higher research and development, general and administrative costs, and other expenses [4] - Cash reserves decreased significantly, indicating a need for careful financial management as the company funds ongoing clinical trials [5] - The company anticipates that existing cash and potential proceeds from in-the-money warrants will sustain operations until at least Q3 2026 [6] Clinical Development - The Phase 2b trial for EP-104GI aims to enroll at least 60 patients across 25 sites globally, focusing on treatment outcomes for eosinophilic esophagitis (EoE) [9] - Recent data from the Phase 1b/2a RESOLVE trial showed sustained positive treatment outcomes in patients after nine months, with no serious adverse events reported [8][9] - The company is optimistic about the potential of EP-104GI to transform the treatment landscape for EoE, with further data updates expected in October 2025 [3][8] Upcoming Events - Eupraxia's management is scheduled to present at several investor conferences, including the Canaccord Growth Conference and the Citi Biopharma Back to School Conference, providing opportunities for investor engagement [12][13]