Core Insights - The article discusses the importance of DMPK (Drug Metabolism and Pharmacokinetics) research in antibody drug development, highlighting the limitations of traditional isotopic labeling methods and the advantages of Revvity's fluorescent probe imaging technology. Group 1: DMPK Research and Traditional Methods - DMPK research is crucial for understanding the behavior of drugs in the body, particularly in evaluating targeted delivery efficiency and potential toxicity mechanisms [1] - Traditional isotopic labeling methods (e.g., 1?C/3H) are costly and require radioactive facilities, making them unsuitable for early-stage screening of antibody drugs [3] Group 2: Revvity's Fluorescent Probe Technology - Revvity's fluorescent probe imaging technology significantly reduces operational costs and time, allowing for dynamic in vivo visualization without the need for radioactive protection [1][4] - The technology supports real-time, non-invasive monitoring of drug distribution in the same animal model, which is particularly beneficial for early screening and mechanism exploration [4] Group 3: Product Offerings and Applications - Revvity's IVISense series fluorescent dyes are designed for labeling antibodies, small molecules, proteins, or peptides, providing high sensitivity for fluorescence imaging [4] - The IVISense 680 NHS Fluorescent Labeling Kit allows for the preparation of fluorescently labeled antibodies or proteins, enhancing research efficiency [10] Group 4: Case Study and Efficacy - A case study demonstrated the use of IVISense 680 NHS Fluorescent Dye in tracking an anti-DNA antibody in a tumor model, showing a correlation between antibody affinity and targeting efficiency [6] - Revvity's technology offers over 50% cost reduction and an 80% reduction in research cycle time compared to traditional isotopic methods, facilitating faster and more intuitive biological insights [13] Group 5: Company Background and Partnerships - Shanghai Weichi focuses on capturing cutting-edge technologies in the biopharmaceutical industry, providing comprehensive solutions from drug development to quality control [14] - The company has established strategic partnerships with multiple brands, including Revvity, to serve over 800 biopharmaceutical clients in China [14]