Key Takeaways Viatris beat Q4 estimates with 57-cent EPS and $3.7B in revenue, up 5% year over year.VTRS saw 8% operational growth in Emerging Markets and Greater China, lifting Brands sales 8%.Viatris guided 2026 revenue to $14.4B-$14.9B and EPS of $2.33-$2.47 after FDA updates.Viatris Inc. (VTRS) delivered fourth-quarter 2025 adjusted earnings per share (EPS) of 57 cents, which beat the Zacks Consensus Estimate of 52 cents. The company recorded an adjusted EPS of 54 cents in the year-ago quarter.Total rev ...

Viatris forecasts 2026 profit below estimates on India manufacturing woes | ReutersSkip to main content[Exclusive news, data and analytics for financial market professionalsLearn more aboutRefinitiv]- Companies[Viatris Inc]Follow[Pfizer Inc]FollowFeb 26 (Reuters) - Drugmaker Viatris [(VTRS.O), opens new tab] forecast annual profit below analysts' expectations on Thursday, after a fire at one of its major plants in India disrupted operations.A fire occurred at the company's manufacturing facility in Nashik, ...

Core Insights - Viatris Inc. (VTRS) reported third-quarter 2025 adjusted earnings per share (EPS) of 67 cents, exceeding the Zacks Consensus Estimate of 63 cents, but down from 75 cents in the same quarter last year [1][7] - Total revenues for the quarter were $3.76 billion, a 2% decline year over year on an operational basis, yet surpassing the Zacks Consensus Estimate of $3.6 billion [1][7] Revenue Breakdown - Total sales reached $3.7 billion, down 2% year over year, with a 1% decline on a divestiture-adjusted operational basis [3] - Sales from Developed Markets were $2.25 billion, down 5% on a divestiture-adjusted operational basis, but slightly above the Zacks Consensus Estimate of $2.20 billion [3] - Emerging Markets generated $570.4 million in sales, reflecting a 7% increase on a divestiture-adjusted operational basis, beating the Zacks Consensus Estimate of $550 million [4] - Sales from Japan, Australia, and New Zealand (JANZ) totaled $306.3 million, down 9% on a divestiture-adjusted operational basis, yet exceeding the Zacks Consensus Estimate of $303 million [4] - Greater China sales amounted to $615.2 million, up 9% on a divestiture-adjusted operational basis, surpassing the Zacks Consensus Estimate of $579 million [4] Product Category Performance - Revenues from Brands increased by 3% to $2.4 billion, with a 1% rise on a divestiture-adjusted operational basis, driven by strong performance in Greater China and Emerging Markets [5] - Key branded products included Lipitor with sales of $396.1 million, Norvasc at $179.7 million, and EpiPen at $157.2 million, while Lyrica sales decreased to $126.5 million [8] Generics Performance - Generics revenue was $1.31 billion, down 5%, with a 6% decline on an operational change basis, primarily due to the impact from the Indore facility [9][10] - The decline in generics was offset by growth in complex products in North America and strong performance in key European markets [9] Financial Guidance and Shareholder Returns - Viatris raised its 2025 revenue guidance to a range of $13.9-$14.3 billion, up from the previous guidance of $13.5-$14 billion, and adjusted EPS guidance to $2.25-$2.35 from $2.16-$2.30 [12] - The company has returned over $920 million to shareholders year to date, including more than $500 million in share repurchases, and is on track to return over $1 billion in 2025 [11] Strategic Developments - Viatris acquired Aculys Pharma, gaining exclusive rights in Japan for pitolisant and plans to file two new drug applications in Japan [13] - The acquisition also includes rights for Spydia Nasal Spray, approved in Japan for treating status epilepticus [14]

Summary of Dogwood Therapeutics (DWTX) FY Conference Call Company Overview - **Company Name**: Dogwood Therapeutics - **Industry**: Biotechnology - **Focus**: Development of novel non-opioid pain treatments targeting the NAV1.7 sodium channel for chronic pain management, particularly in cancer-related pain and chemotherapy-induced neuropathic pain [1][2][3] Core Product: Halneuron® - **Description**: Halneuron® is a NAV1.7 inhibitor, an injectable therapy aimed at reducing pain associated with cancer and chemotherapy-induced neuropathy [1][5] - **Clinical Stage**: Currently in phase 2b study [1] - **Target Patient Group**: Patients experiencing moderate to severe neuropathic pain post-chemotherapy, with about 70% of chemotherapy patients experiencing neuropathy [2][10] Clinical Data and Results - **Unmet Medical Need**: High demand for effective treatments for cancer-related pain, with millions of patients suffering globally [10] - **Study Results**: - 51% of patients treated with Halneuron® showed a 30% reduction in pain, and a 50% reduction in opioid use [11] - Placebo response rate was 35%, indicating Halneuron®'s effectiveness [11] - Durable effect observed, with patients experiencing pain relief for an average of 58 days post-treatment compared to one week for placebo [12] - **Current Phase 2b Study**: - 200 patients, assessing Halneuron® administered once daily over two weeks [14] - Primary endpoint assessed 30 days after the first dose [14] - Interim results expected by December 2025, with final results projected for mid-2026 [18][19] Regulatory Strategy - **FDA Interaction**: The company has established a good relationship with the FDA, aiming for a collaborative approach to drug approval [24] - **Fast-Track Designation**: Halneuron® has received fast-track review designation from the FDA due to its novel approach and high unmet medical need [15] Intellectual Property (IP) and Commercial Strategy - **Current IP**: Based on the unique process of collecting tetrodotoxin from pufferfish, with plans to file new IP for a synthetic formulation [29] - **Commercialization Strategy**: The company is open to partnerships but prioritizes data-driven decisions for maximizing shareholder value [30][31] Financial Position - **Cash Position**: Approximately $13.5 million on hand, sufficient to fund operations through Q1 of the following year [32] - **Burn Rate**: Low operational costs due to a small team of about 12-13 employees [32] Future Outlook - **Next Steps**: If phase 2b is successful, the company plans to initiate a phase 3 program in early 2027 and explore broader cancer-related pain studies [25][26] - **Potential Market**: With 20 million new cancer cases annually, the commercial opportunity for Halneuron® is significant [16] Additional Insights - **Team Experience**: The management team has a strong background in pain drug development, having successfully brought multiple pain medications to market [4][30] - **Synthetic Formulation**: Development of a synthetic version of tetrodotoxin is expected to improve yield, reduce costs, and enhance regulatory acceptance [21]

Core Insights - Viatris Inc. reported second-quarter 2025 adjusted earnings of 62 cents per share, exceeding the Zacks Consensus Estimate of 56 cents, but down from 69 cents per share in the same quarter last year [1][7] - Total revenues for the quarter were $3.58 billion, a decrease of 6% year over year, yet surpassing the Zacks Consensus Estimate of $3.5 billion [1][5] - The company's share price has declined 29.7% year to date, compared to an 8.6% decline in the industry [2] Revenue Breakdown - Sales from Developed Markets were $2.11 billion, down 4% on a divestiture-adjusted operational basis, but above the Zacks Consensus Estimate of $2.01 billion [5] - Emerging Markets generated sales of $555.1 million, up 1% on a divestiture-adjusted operational basis, beating the Zacks Consensus Estimate of $542 million [6] - Sales from Japan, Australia, and New Zealand (JANZ) totaled $305.7 million, down 11% on a divestiture-adjusted operational basis, missing the Zacks Consensus Estimate of $310 million [6] - Greater China sales reached $588.9 million, up 9% on a divestiture-adjusted operational basis, exceeding the Zacks Consensus Estimate of $546 million [6] Product Category Performance - Revenues from Brands decreased 3% to $2.3 billion, but increased 3% on a divestiture-adjusted operational basis, driven by strong performance in Greater China and Emerging Markets [7] - Lipitor sales rose to $388 million, Norvasc sales increased to $182.7 million, and Lyrica sales grew to $128.1 million compared to the previous year [8] - Generics revenues were $1.28 billion, down 10%, with a 9% decline on an operational change basis, attributed to the negative impact from the Indore facility [9] Financial Metrics - Adjusted gross margin was 56.3%, down from 58.4% in the prior year [11] - The company has returned over $630 million to shareholders in the year to date, including more than $350 million in share repurchases [11] - Viatris expects total share repurchases of $500 million to $650 million in 2025 [11] Guidance and Updates - The company reaffirmed its 2025 revenue guidance of $13.5 billion to $14 billion and raised its adjusted earnings per share forecast to a range of $2.16 to $2.30 [12] - Positive top-line results were announced from phase III studies evaluating MR-142 and MR-141 for treating vision impairments [13] - A phase III study for MR-139 did not meet its primary endpoint [14]

Core Viewpoint - Viatris Inc. (VTRS) reported better-than-expected first-quarter adjusted earnings of 50 cents per share, surpassing the Zacks Consensus Estimate of 49 cents, although down from 67 cents per share in the same quarter last year [1][15] Financial Performance - Total revenues for the quarter were $3.25 billion, reflecting an 11% year-over-year decline, but still exceeding the Zacks Consensus Estimate of $3.23 billion [1][15] - Adjusted gross margin decreased to 55.9% from 58.8% year-over-year [10] Sales Breakdown - Sales from Developed Markets were $1.9 billion, down 3% on a divestiture-adjusted operational basis, missing the Zacks Consensus Estimate of $1.93 billion [4] - Emerging Markets generated $519.9 million in sales, down 5% on a divestiture-adjusted operational basis, but beating the Zacks Consensus Estimate of $464 million [5] - Sales from Japan, Australia, and New Zealand (JANZ) totaled $276.1 million, down 6% and missing the Zacks Consensus Estimate of $309 million [5] - Greater China sales increased by 4% to $555.5 million, surpassing the Zacks Consensus Estimate of $553 million [5] Product Category Performance - Revenues from Brands decreased by 8% to $2.1 billion, but increased by 3% on a divestiture-adjusted operational basis [6] - Lipitor sales were $388 million, relatively flat year-over-year, while Norvasc and Lyrica sales declined [6] - Generics revenue was $1.1 billion, down 16%, with an operational decline of 11% [7][9] Future Guidance - Viatris maintains its total revenue guidance for 2025 at $13.5-$14 billion and adjusted earnings per share guidance at $2.16-$2.30, updated from a previous range of $2.12-$2.26 [12] Research and Development Updates - Positive results were reported from phase III studies for Effexor and a novel formulation of meloxicam, with plans to submit a new drug application to the FDA by the end of 2025 [13][14]

Core Viewpoint - Pfizer has experienced significant stock price declines since its peak in late 2021, primarily due to reduced sales of its COVID-19 treatments and vaccines, but it still holds potential for future growth, particularly in oncology and offers an attractive dividend yield [2][4][5] Group 1: Stock Performance - Pfizer's stock has seen over a 60% decline from its late-2021 high, with a $10,000 investment from 10 years ago now worth just over $7,000 [2] - Including reinvested dividends, the investment would be worth approximately $10,600 over the same period, although this still lags behind broader market returns [3] Group 2: Sales and Market Reaction - The decline in stock value is largely attributed to slowing sales of its COVID-19 treatment Paxlovid and vaccine Comirnaty, with no compensating growth from other products in its portfolio [4] Group 3: Future Outlook - Despite recent setbacks, there are new growth prospects for Pfizer, especially in oncology, and the stock's forward-looking dividend yield of 7.5% may attract new investors confident in the company's future [5]