Matuszewski highlighted publication of top-line results from a diabetic foot ulcer (DFU) clinical trial in the fourth quarter, saying the study showed “clear superiority” of BioStem’s BioREtain-processed product over standard of care. He said the company expects to publish additional DFU analyses in coming months and also expects to publish top-line results for its venous leg ulcer (VLU) study.In the fourth quarter of 2025, BioStem’s revenue consisted only of physician office customer sales, before the acqu ...

POMPANO BEACH, Fla., March 24, 2026 (GLOBE NEWSWIRE) -- BioStem Technologies, Inc. (OTC: BSEM), a leading regenerative medicine company focused on the development, manufacturing, and commercialization of perinatal tissue allograft products, today reported financial results for the fourth quarter and full year ended December 31, 2025. Recent Financial and Business Highlights Generated net revenue of $10.1 million for the fourth quarter 2025 and gross margin of 97%Completed the acquisition of the BioTissue H ...

Company Presentation MARCH 2026 Forward Looking Statements Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations and assumptions. The Company's actual results and financial condition may differ materially from those indicated in the forward-looking statements. The following is a list of risks, among others, that could cause actual results to differ materially from those contemplated by the forward-looki ...

Summary of BioStem Technologies Conference Call Company Overview - **Company**: BioStem Technologies - **Industry**: Regenerative Medicine, Wound Care - **CEO**: Jason Matuszewski - **Conference**: 46th Annual TD Cowen Healthcare Conference Core Points and Arguments - **Mission**: BioStem aims to create and deliver advanced wound healing technologies, addressing the significant challenges posed by chronic and acute wounds, which have an estimated economic impact of over $30 billion annually in the U.S. [2][4] - **Key Pillars**: The company is built on three pillars: differentiated technology, strong operational and clinical foundation, and a scalable growth engine [3] - **Technologies**: BioStem's technology platform includes BioREtain, CryoTek, and SteriTek, with a focus on perinatal-derived allograft brands like Neox and Clarix [3] - **Intellectual Property**: The company holds 58 issued U.S. patents and 68 pending patents, showcasing a strong IP portfolio [3] - **Market Opportunity**: BioStem targets a multi-billion dollar market, with a soft tissue allograft opportunity exceeding $23 billion across six core segments: orthopedics, chronic wound care, foot and ankle, urology, spine, and women's health [5] Financial Performance - **Revenue**: In 2025, the surgical revenue generated approximately $29 million, largely unaffected by CMS's wound pricing changes [6] - **EBITDA**: The BioTissue surgical and wound care assets delivered a single-digit positive EBITDA in 2025 [17] - **Cash Position**: The company has around $16 million in cash on the balance sheet, indicating a strong position for future investments [18] Market Dynamics - **Reimbursement Changes**: The transition from a bundled payment system to a fixed rate per square centimeter allows for treatment of larger wounds, which is expected to enhance market access [12][13] - **Challenges**: There are concerns regarding access to products in physician offices and mobile wound care settings due to the new reimbursement rates [27][28] - **Regulatory Environment**: The company is focused on generating clinical evidence to support reimbursement and market access, particularly in light of changing LCDs and payment methodologies [29] Strategic Initiatives - **Acquisition Impact**: The acquisition of BioTissue has expanded BioStem's product offerings and market reach, with a focus on diversifying the portfolio and driving growth [5][10] - **Sales Expansion**: The company has increased its sales force with 18 direct representatives and over 30 independent agents, aiming to penetrate new markets and enhance distribution [20] - **Future Products**: BioStem is looking forward to a 510(k) product launch in the middle to back half of the year, which will further diversify its offerings [4][19] Leadership and Management - **Management Team**: The company has assembled a leadership team with extensive experience in clinical research, commercial education, manufacturing, regulatory, and finance [16] - **New Appointments**: Barry Hassett has been appointed as Chief Commercial Officer, and Lita Lilly as VP of Sales, both bringing valuable experience from BioTissue [17] Conclusion - **Long-term Vision**: BioStem is positioned to capitalize on opportunities in regenerative medicine, leveraging its platform of perinatal tissues and focusing on evidence-based approaches to support its growth strategy [21]

Core Insights - BioTissue Holdings, Inc. has completed the sale of its non-ocular Surgical and Wound Care business to BioStem Technologies, Inc., allowing BioTissue to focus on ocular market leadership and innovation in eye care solutions [1][2][3] Company Overview - BioTissue specializes in utilizing human birth tissue for regenerative healing, particularly in treating acute and chronic ocular surface conditions [4] - The company has developed a portfolio of cryopreserved amniotic membrane products using proprietary CryoTek® technology, which preserves the tissue's structural and functional integrity [4] - BioTissue has conducted over 1 million human procedures with its products and has over 420 peer-reviewed publications supporting its technology [4] Strategic Focus - Following the divestiture, BioTissue will concentrate on advancing interventional therapies for ocular conditions, including products like Prokera, CAM360 AmnioGraft, and AmnioGuard [2][3] - The company aims to prioritize product innovation, professional education, and comprehensive customer support within the eye care market [2] Partnership with BioStem - BioStem Technologies will acquire exclusive rights to BioTissue's Neox and Clarix product lines, integrating BioTissue's surgical sales team into its commercial organization [2][3] - BioStem's CEO highlighted the complementary strengths of BioTissue's portfolio to their existing business, indicating a strong potential for growth and improved patient outcomes [3]

Core Viewpoint - BioStem Technologies, Inc. has acquired the surgical and wound care business of BioTissue Holdings Inc. for approximately $15 million, enhancing its commercial organization and expanding its market reach in advanced wound care [1][4][5]. Group 1: Acquisition Details - BioStem has closed a definitive asset purchase agreement with BioTissue, acquiring its full portfolio of surgical and wound care assets, including the Neox and Clarix product lines [2][3]. - The acquisition includes a nationwide network of sales representatives and independent agents, along with key GPO contracts, significantly expanding BioStem's commercial capabilities [2][3]. - The total upfront cash payment for the acquisition is approximately $15 million, with potential additional payments of up to $25 million based on regulatory and commercial milestones [4][5]. Group 2: Financial Impact - The acquired assets generated approximately $29 million in sales in 2025 and are expected to contribute positively to BioStem's EBITDA in 2026 [5]. - Post-acquisition, BioStem's cash and restricted cash balance is approximately $16 million [5]. Group 3: Leadership Changes - Barry Hassett has been promoted to Chief Commercial Officer to lead the newly combined commercial team, bringing over 25 years of industry experience [6].

Group 1 - Atresmedia Corporación de Medios de Comunicación experienced a significant increase in short interest, rising by 116.4% from 640 shares on November 30th to 1,385 shares by December 15th [2] - The average daily trading volume is 2,052 shares, resulting in a days-to-cover ratio of 0.7 days [2] - The stock opened at $5.60, with a fifty-day moving average of $6.09 and a 200-day moving average of $6.13 [3] Group 2 - Atresmedia is a leading Spanish multimedia group that operates a diverse portfolio of free-to-air television channels, including flagship networks Antena 3 and laSexta [4] - The company also manages thematic channels such as Neox, Nova, Mega, and Atreseries, catering to various audience segments with a range of content [4] - In addition to television, Atresmedia operates a network of radio stations, including Onda Cero, Europa FM, and Melodía FM [5]