Market Overview - U.S. stocks experienced a decline, with the Dow Jones falling approximately 250 points, down 0.53% to 47,465.86, the NASDAQ down 0.22% to 23,313.48, and the S&P 500 down 0.26% to 6,831.40 [1] - Energy shares increased by 1%, while utilities stocks decreased by 2.1% [1] Economic Indicators - The ISM manufacturing PMI fell to 48.2 in November, marking the lowest level in four months, down from 48.7 in the previous month and below market expectations of 48.6 [2][11] - The S&P Global manufacturing PMI was revised up to 52.2 in November from a preliminary reading of 51.9, but down from October's final reading of 52.5 [11] Commodity Market - Oil prices rose by 1.4% to $59.40, gold increased by 0.2% to $4,263.90, silver climbed 2.8% to $58.765, and copper rose 0.6% to $5.3050 [5] European Market - European shares were predominantly lower, with the eurozone's STOXX 600 down 0.20%, while Spain's IBEX 35 Index rose 0.11%. The FTSE 100 fell 0.18%, Germany's DAX 40 dipped 1.04%, and France's CAC 40 decreased by 0.32% [6] Asian Market - Asian markets closed mixed, with Japan's Nikkei down 1.89%, Hong Kong's Hang Seng up 0.67%, China's Shanghai Composite up 0.65%, and India's BSE Sensex down 0.08% [7] Company News - Q32 Bio Inc. shares surged 103% to $4.4404 after selling its Phase 2 complement inhibitor ADX-097 to Akebia for $12 million upfront, with potential milestone and royalty payments up to $592 million [9] - New Fortress Energy Inc. shares rose 15% to $1.4050 following news of conditional approval for a large liquified natural gas supply contract [9] - KALA BIO, Inc. shares increased by 86% to $1.8004 after securing a $6 million securities purchase agreement and appointing David Lazar as CEO and Chairman [9] - Sionna Therapeutics, Inc. shares fell 16% to $36.42 after being downgraded by RBC Capital from Sector Perform to Underperform [9] - CN ENERGY GROUP Inc shares dropped 17% to $1.2101 after announcing the launch of its PATHENBOT Robotics Solutions Platform [9] - Bitmine Immersion Technologies, Inc. shares fell 13% to $28.96, with crypto-linked stocks declining after Bitcoin fell below $86,000 [9]

Market Overview - U.S. stocks traded lower, with the Dow Jones falling approximately 200 points, down 0.42% to 47,515.41, NASDAQ down 1.08% to 23,113.36, and S&P 500 down 0.68% to 6,802.39 [1] - European shares were mostly lower, with the eurozone's STOXX 600 down 0.4%, Spain's IBEX 35 Index down 0.1%, London's FTSE 100 up 0.1%, Germany's DAX 40 down 1.1%, and France's CAC 40 down 0.4% [5] - Asian markets closed mixed, with Japan's Nikkei down 1.89%, Hong Kong's Hang Seng up 0.67%, China's Shanghai Composite up 0.65%, and India's BSE Sensex down 0.08% [6] Economic Indicators - The S&P Global manufacturing PMI was revised higher to 52.2 in November from a preliminary reading of 51.9, but down from October's final reading of 52.5 [2][7] Commodity Market - Oil traded up 1.7% to $59.53, gold up 0.2% to $4,261.40, silver up 0.9% to $57.62, and copper rose 0.8% to $5.3150 [4] Company Performance - Q32 Bio Inc. shares surged 171% to $5.91 after selling its Phase 2 complement inhibitor ADX-097 to Akebia for $12 million upfront and potential milestone and royalty payments up to $592 million [8] - Ambitions Enterprise Management Co. L.L.C shares increased 102% to $9.75 [8] - KALA BIO, Inc. shares rose 47% to $1.42 after securing a $6 million securities purchase agreement and appointing David Lazar as CEO and Chairman [8] - Paranovus Entertainment Technology Ltd. shares dropped 81% to $0.1996 [8] - CN ENERGY GROUP Inc shares fell 18% to $1.19 after announcing the launch of PATHENBOT Robotics Solutions Platform [8] - Rubico Inc shares decreased 19% to $0.13 following a 1-for-30 reverse stock split [8]