Access the Akari CEO Corner here BOSTON and LONDON, Nov. 25, 2025 (GLOBE NEWSWIRE) -- Akari Therapeutics, Plc (Nasdaq: AKTX), an oncology biotechnology company developing novel payloads for antibody drug conjugates (ADCs), today announced the next CEO Corner segment has been published on the Company’s website. For this CEO Corner segment, Abizer Gaslightwala, CEO of Akari, provides an overview of the Company’s innovation in ADCs, highlighting its novel PH1 payload and its dual mechanism of action. Additiona ...

More than 20 years of financial and operational leadership in biopharma, including $170M+ in capital raised, global commercialization experience, and a proven track record scaling companies from preclinical to clinical milestonesTAMPA and LONDON, Nov. 18, 2025 (GLOBE NEWSWIRE) -- Akari Therapeutics, Plc (Nasdaq: AKTX), an oncology biotechnology company developing novel payloads for antibody drug conjugates (ADCs), today announced the appointment of Kameel D. Farag as its Interim Chief Financial Officer who ...

Core Insights - Akari Therapeutics is presenting new data on its novel antibody drug conjugate (ADC) payload, PH1, at the 40th Annual SITC Meeting, highlighting its immune mechanism-of-action and potential in oncology treatment [1][2]. Company Overview - Akari Therapeutics is focused on developing next-generation spliceosome payload ADCs, with its lead candidate, AKTX-101, targeting the Trop2 receptor on cancer cells [5]. - The PH1 payload is a spliceosome modulator designed to disrupt RNA splicing in cancer cells, showing preclinical efficacy in inducing cancer cell death and activating immune responses [5]. Research Findings - The abstract presented at SITC indicates that the PH1 ADC, in combination with anti-PD-1, resulted in a higher rate of complete tumor regressions compared to a first-in-class ADC with a microtubule inhibitor payload [2]. - The immune response stimulated by the PH1 ADC involves neoantigen activation, antigen-presenting cells, and T-cell activation, leading to enhanced therapeutic potential [2]. Presentation Details - The oral and poster presentations will provide further insights into the findings, with specific sessions scheduled for November 7 and November 9, 2025 [3][4].

Core Insights - Akari Therapeutics is presenting data on its novel antibody drug conjugate (ADC) payload, PH1, at the 40th Annual Society for Immunotherapy of Cancer (SITC) Meeting, highlighting its immune mechanism-of-action and potential in oncology [1][2] Company Overview - Akari Therapeutics is focused on developing next-generation spliceosome payload ADCs, with its lead candidate, AKTX-101, targeting the Trop2 receptor on cancer cells [5][6] - The PH1 payload is designed to disrupt RNA splicing within cancer cells, showing preclinical efficacy in inducing cancer cell death and activating immune cells [5][6] Research Findings - The abstract presented at SITC indicates that the PH1 ADC, in combination with anti-PD-1, resulted in a higher rate of complete tumor regressions compared to a first-in-class ADC with a microtubule inhibitor payload [2] - The immune response stimulated by the PH1 ADC is attributed to neoantigen activation, which enhances the activity of antigen-presenting cells, B, and T-cells [2] - Notably, the combination of PH1 ADC and anti-PD-1 expanded the population of gamma-delta T cells, which are effective in tumor killing [2] Presentation Details - The oral and poster presentations will take place on November 7 and 9, 2025, at the Gaylord National Resort and Convention Center, with specific times and locations provided for attendees [3][4]

Core Insights - Akari Therapeutics has launched a new platform called CEO Corner, aimed at providing deeper insights into the company's press releases, corporate developments, and pipeline progress [2][3] - The CEO Corner will allow stakeholders to ask questions and suggest topics for future discussions, enhancing engagement and transparency [1][2] Company Overview - Akari Therapeutics is focused on developing next-generation spliceosome payload antibody drug conjugates (ADCs) for oncology applications [4] - The company's lead candidate, AKTX-101, targets the Trop2 receptor on cancer cells and utilizes a proprietary linker to deliver a novel PH1 payload directly into tumors [4] - PH1 is designed to modulate RNA splicing within cancer cells, leading to cancer cell death and activation of immune responses, showing significant activity in preclinical studies compared to traditional ADCs [4] Product Development - AKTX-101 has demonstrated prolonged survival in preclinical models, both as a single agent and in combination with checkpoint inhibitors, indicating its potential for synergistic effects [4] - The company is actively generating validating data on the PH1 payload to further advance AKTX-101 and explore other undisclosed targets [4]

Core Insights - Akari Therapeutics has filed two new provisional patent applications with the USPTO, focusing on its novel immuno-oncology payload PH1 and its combination therapy with other immuno-oncology drugs [1][2][3] Patent Applications - The first patent application protects Akari's novel immuno-oncology payload PH1, which is a Thailanstatin analog, and its mechanism of action that activates the host immune system against cancer [1] - The second application covers a combination therapy of PH1 ADCs with other immuno-oncology drugs that alleviate checkpoint inhibition, demonstrating synergy in preclinical models [1][3] Strategic Goals - The patent filings are part of Akari's strategy to establish a new class of immuno-oncology ADC therapies, building on the success of checkpoint inhibitors [2] - The company aims to enhance its intellectual property estate to create long-term value for itself and potential partners [2] Clinical Implications - Akari's data suggest the potential for a new ADC paradigm targeting cancer through spliceosome modulation, which could improve clinical outcomes compared to existing therapies [4] - Checkpoint inhibitors currently benefit only 20-30% of patients, indicating a significant opportunity for Akari's innovative approach [4] Pipeline Development - Akari is expanding its ADC pipeline to include multiple targets, such as AKTX-101 (Trop2 ADC with PH1 payload) and future programs like AKTX-102 [5][6] - The lead candidate AKTX-101 has shown significant activity and prolonged survival in preclinical studies, with potential synergy with checkpoint inhibitors [6]

Core Insights - Akari Therapeutics, Plc is an oncology biotechnology company focused on developing novel payload antibody drug conjugates (ADCs) [1][2] - The company’s lead candidate, AKTX-101, targets the Trop2 receptor on cancer cells and utilizes a proprietary linker to deliver a novel spliceosome modulator payload, PH1, designed to disrupt RNA splicing [2] - AKTX-101 has shown significant preclinical activity, inducing cancer cell death and activating immune cells, with potential synergy with checkpoint inhibitors [2] Presentation Details - Akari Therapeutics will present an abstract at the 40th Annual SITC Meeting, scheduled for November 5-9, 2025 [1] - The presentation titled "A Novel Splicing-Targeted ADC Payload Drives Immune Activation, Synergy with Checkpoint Inhibitors, and Enhanced Therapeutic Potential beyond Cytotoxicity" will be delivered by Dr. Satyajit Mitra [1] - The oral presentation is set for November 9, 2025, at 11:05 AM ET, with a poster presentation on November 7, 2025 [1]

Core Insights - Akari Therapeutics has announced promising preclinical data for its novel antibody drug conjugate (ADC) payload, PH1, which targets the AR-V7 receptor linked to hormone refractory prostate cancer progression [1][2][3] Group 1: Product Development - PH1 has shown the ability to suppress AR-V7 receptor expression in a hormone-refractory metastatic castration resistant prostate cancer (mCRPC) model, indicating its potential effectiveness where current therapies fail [3] - In hormone-sensitive LnCAP cells, PH1 demonstrated single-agent benefits and additive effects when combined with existing therapies like Xtandi and Erleada, suggesting potential for first-line combination regimens [4] - The company aims to develop PH1 ADCs as either first-line therapies with ARPIs or second-line therapies for patients who have failed ARPI treatments [5] Group 2: Market Context - There is a significant unmet need for effective therapies in ARPI-resistant hormone refractory prostate cancer, as current options are limited primarily to traditional chemotherapy [2] - Current first-line therapies, including enzalutamide (Xtandi), apalutamide (Erleada), and darolutamide (Nubeqa), have substantial annual sales, indicating a lucrative market for effective alternatives [2] Group 3: Company Overview - Akari Therapeutics specializes in developing next-generation spliceosome payload ADCs, with its lead candidate, AKTX-101, targeting the Trop2 receptor and utilizing a novel PH1 payload [6] - The company’s innovative ADC discovery platform allows for the generation and optimization of ADC candidates tailored to specific targets, enhancing its competitive edge in oncology [6][7]

Core Insights - Akari Therapeutics has announced promising preclinical data for its novel antibody drug conjugate (ADC) payload, PH1, which targets the AR-V7 receptor linked to hormone refractory prostate cancer progression [1][2][3] Group 1: Product Development - The ADC payload PH1 has shown the ability to suppress AR-V7 receptor expression in a hormone-refractory metastatic castration resistant prostate cancer (mCRPC) model, indicating its potential effectiveness where current therapies fail [3][4] - In a hormone-sensitive model, PH1 demonstrated single-agent benefits and additive effects when combined with existing therapies like Xtandi and Erleada, suggesting potential for first-line combination regimens [4][5] - Akari aims to develop the first ADC therapeutic for prostate cancer, targeting both first-line and second-line treatment scenarios for AR-V7 driven tumors [5] Group 2: Market Context - There is a significant unmet need for effective therapies in ARPI-resistant hormone refractory prostate cancer, as current options are limited primarily to traditional chemotherapy [2][4] - Current first-line therapies, including enzalutamide, apalutamide, and darolutamide, have substantial annual sales, indicating a lucrative market for effective alternatives [2] Group 3: Company Overview - Akari Therapeutics specializes in developing next-generation spliceosome payload ADCs, with a focus on innovative therapeutic mechanisms that differ from traditional ADCs [6][7] - The lead candidate, AKTX-101, targets the Trop2 receptor and utilizes a proprietary linker to deliver the PH1 payload directly into tumors, aiming for enhanced efficacy and survival outcomes [6][7]

Company Overview - Akari Therapeutics is an oncology biotechnology company focused on developing next-generation spliceosome payload antibody drug conjugates (ADCs) [4] - The company utilizes an innovative ADC discovery platform to generate and optimize ADC candidates for various targets [4] Lead Product Candidate - Akari's lead candidate, AKTX-101, targets the Trop2 receptor on cancer cells and employs a proprietary linker to deliver a novel PH1 payload directly into tumors [4] - PH1 is a spliceosome modulator designed to disrupt RNA splicing within cancer cells, leading to cancer cell death and activation of immune cells [4] - Preclinical studies indicate that AKTX-101 has significant activity and prolonged survival compared to traditional ADCs, and it shows potential synergy with checkpoint inhibitors [4] Upcoming Events - Abizer Gaslightwala, President and CEO of Akari Therapeutics, will present at the H.C. Wainwright 27th Annual Global Investment Conference from September 8-10, 2025 [1] - Management will also be available for in-person one-on-one meetings with qualified investors during the conference [2] - A video webcast of the presentation will be available on-demand starting September 5, 2025, and will be archived for 90 days [3]