Core Insights - Replimune Group, Inc. presented data on RP1 plus nivolumab at the 2025 ASCO Annual Meeting, highlighting robust responses in both injected and non-injected lesions, with deep injections showing higher response rates compared to superficial injections [1][2][4] Group 1: Clinical Trial Findings - The IGNYTE clinical trial involved 140 anti-PD-1 failed melanoma patients, showing an objective response rate (ORR) of 32.9% and a complete response rate of 15.0% [4] - Landmark overall survival (OS) rates at 1, 2, and 3 years were reported as 75.3%, 63.3%, and 54.8% respectively, with median OS not yet reached [4] - Deep injections resulted in higher ORR: 29.8% for superficial injections, 42.9% for deep/visceral plus superficial injections, and 40.9% for deep/visceral injections only [4] Group 2: Safety and Tolerability - RP1 injections into the liver and lung were generally well tolerated, with few organ-specific adverse events [4] - No bleeding events were reported after liver injections, and lung injections had low rates of pneumothorax, typically of low grade and manageable [4] - Standard disinfection procedures were confirmed sufficient for RP1 clean-up, with no transmission of RP1 reported to date [10] Group 3: Product Information - RP1 is Replimune's lead product candidate, engineered from a proprietary strain of herpes simplex virus, designed to maximize tumor killing potency and activate a systemic anti-tumor immune response [6][8] - The RPx platform aims to induce a strong and durable systemic response while being synergistic with various cancer treatment modalities [8]

Core Viewpoint - Raspberry Pi has launched the RP2350 microcontroller, which features significant improvements in performance, security, and power efficiency compared to its predecessor, the RP2040 [1][2][3]. Pricing and Availability - The RP2350A (7×7 QFN60) is priced at $1.10 per unit, while the RP2350B (10×10 QFN80) is priced at $1.20 per unit. Bulk purchases significantly reduce the price, with the RP2350A available for $0.80 per unit when buying 3,400 units [1][2]. - The RP2354A and RP2354B models, which will include 2MB stacked flash memory, are in the final stages of development and testing, with plans for mass production later this year [1][5]. Technical Specifications - The RP2350 integrates dual Arm Cortex-M33 processors running at 150MHz, supporting floating-point operations and DSP, along with a security model based on Arm TrustZone [3][4]. - The microcontroller features enhanced power efficiency, with the ability to reduce power consumption to less than one-tenth of the previous model when in low-power mode [3][4]. Design Improvements - The RP2350 replaces the voltage regulator with a more efficient converter, allowing for higher peak current delivery and improved efficiency in low-power modes [4]. - The design retains many elements from the RP2040, allowing for quicker integration and development while also introducing new features such as OTP and core power regulation [5].