Key Takeaways EDIT advances CRISPR-based EDIT-401, showing over 90% LDL-C reduction in preclinical tests.SANA pushes ex vivo and in vivo platforms, with IND plans for SC451 in 2026 and SG293 in 2027.PACB delivers advanced long-read sequencing tools serving research, clinical and commercial users.An updated edition of the Sept. 18, 2025, article.Genomics is a comprehensive study of genomes (an organism’s complete set of deoxyribonucleic acid or DNA). Given the recent promising breakthroughs in this field, th ...

Core Insights - Sana Biotechnology is increasing its focus on SC451, a therapy for type 1 diabetes, and SG293, an in vivo CAR T product, while suspending other allogeneic CAR T studies to allocate resources effectively [1][2][3] Financial Highlights - The company raised gross proceeds of $115.8 million from common stock sales in Q3 2025, with a cash position of $153.1 million as of September 30, 2025, expected to last into late 2026 [1][7] - Research and development expenses for Q3 2025 were $30.1 million, down from $53.2 million in Q3 2024, reflecting a strategic portfolio prioritization [13][19] - The net loss for Q3 2025 was $42.2 million, or $0.16 per share, compared to a net loss of $59.9 million, or $0.25 per share, in Q3 2024 [19][28] Clinical Development Updates - Positive results from a 12-week clinical study of UP421, a hypoimmune-modified pancreatic islet cell therapy, were published, showing safety and insulin production without immunosuppression [4][9] - The company plans to file an Investigational New Drug Application (IND) for SC451 as early as 2026 and for SG293 as early as 2027, with both therapies showing promising preclinical data [1][3][9] Strategic Focus - The decision to concentrate on SC451 and SG293 is based on recent progress and the potential for transformative impacts in treating type 1 diabetes and B-cell cancers [3][4] - The company has suspended enrollment in its allogeneic CAR T programs, SC291 and SC262, to focus resources on the more promising SC451 and SG293 [2][3]