Core Insights - Charles River Laboratories International, Inc. (CRL) is valued at a market cap of $9.2 billion and provides drug discovery, non-clinical development, and safety testing services, partnering with various institutions to accelerate research and drug development [1] Financial Performance - Analysts expect CRL to report a profit of $2.32 per share for fiscal Q3 2025, a decrease of 10.4% from $2.59 per share in the same quarter last year [2] - For fiscal 2025, CRL is projected to report a profit of $10.17 per share, down 1.5% from $10.32 per share in fiscal 2024, but is expected to rebound to $10.71 per share in fiscal 2026, reflecting a year-over-year growth of 5.3% [3] Stock Performance - Over the past 52 weeks, CRL has gained marginally, underperforming the S&P 500 Index's 14.5% increase but outperforming the Health Care Select Sector SPDR Fund's 3.4% decline [4] Recent Earnings and Guidance - Following its Q2 earnings release, CRL's shares fell 10.3% despite better-than-expected results, with revenue of $1 billion and adjusted EPS of $3.12 exceeding consensus estimates [5] - The modest revenue growth was attributed to favorable foreign currency movements, while organic revenue declined due to weakness in the Discovery and Safety Assessment (DSA) segment [5] - In light of its Q2 results and expectations for a gradual recovery in the DSA segment, CRL raised its fiscal 2025 guidance, projecting adjusted EPS between $9.90 and $10.30, with revenue expected to decline modestly by 0.5% to 2.5% [6]

Core Insights - ClearBridge Investments reported a significant rally in US equities during Q2 2025, with the S&P 500 returning 10.9% and the Russell Midcap Growth Index advancing 18.2% [1] - The ClearBridge Growth Strategy outperformed its benchmark, driven by strong performance in the "mid cap plus" segment and solid stock selection in IT, industrials, and financials [1] Company Overview: Charles River Laboratories International, Inc. (CRL) - Charles River Laboratories provides drug discovery, non-clinical development, and safety testing services through various segments [2] - The stock experienced a one-month return of 5.00% and a 52-week gain of 26.44%, closing at $151.60 with a market capitalization of $7.461 billion on September 16, 2025 [2] Investment Strategy and Performance - ClearBridge Growth Strategy closed positions in MongoDB and Charles River Laboratories to focus on higher-conviction growth names due to a challenging biotech funding environment and regulatory risks [3] - The company reported revenue of $1.03 billion in Q2 2025, reflecting a 0.6% increase from Q2 2024 [4] - Despite the potential of Charles River Laboratories, the company is not among the 30 most popular stocks among hedge funds, with 49 hedge fund portfolios holding the stock at the end of Q2 2025, up from 39 in the previous quarter [4]