Rockwell Automation (ROK) FY Conference May 08, 2025 02:15 PM ET Speaker0 Well, good afternoon, everyone, and, welcome back to day four of Oppenheimer's twentieth Annual Industrial Growth Conference. We're very happy to have, back to the conference, Rockwell Automation, Ajana Zehlner, head of IR and market strategy. Known each other many years, and I really appreciate you making the time right after earnings to come talk to us. So, Ajana, let's Speaker1 Would have missed it. Speaker0 Let's get into it. You ...

Summary of Rapport Therapeutics Conference Call Company Overview - **Company**: Rapport Therapeutics - **Focus**: Developing precision neuroscience therapeutics, particularly for focal epilepsy with lead program RAP219 [1][2] - **Background**: Company spun out from technology developed by Dr. David Brett, with a history at UCSF and Eli Lilly [3] Key Points Financials and Development Timeline - **Public Offering**: Company went public in June of the previous year [3] - **Cash Position**: Ended the year with approximately $285 million, sufficient to fund operations through at least the end of the next year [4] - **Upcoming Milestones**: - Phase two trial readout for focal onset patients expected in Q3 [4] - Initiation of bipolar mania trial in Q3 with data expected in early 2027 [4] Scientific Approach - **Technology**: Focus on receptor-associated protein technology to target specific areas in the brain, enhancing drug precision [3] - **Lead Program**: RAP219 targets AMPA receptors through the accessory protein gamma-eight TARP, aiming to reduce side effects associated with non-selective targeting [5][8] - **Preclinical and Phase One Data**: - Strong preclinical data supporting the targeting approach, with a focus on receptor occupancy and therapeutic index [14][15] - Phase one PET study confirmed receptor occupancy exceeding 80% at therapeutic concentrations [15][17] Clinical Trial Design - **Innovative Trial Design**: - Utilizes an RNS device to track long episodes of epileptic activity, providing objective data [20][25] - Aims to correlate long episode frequency with clinical seizure frequency, with a target of a 30% decrease in long episodes correlating with a 50% decrease in clinical seizures [34] - **Success Metrics**: - Aiming for a responder rate of 40% or greater in the trial participants [36] - Combination of clinical seizure diary data and objective electrographic biomarkers to validate findings [39] Market Opportunity - **Focal Epilepsy Market**: Approximately 1.8 million patients with focal epilepsy, with 40% still experiencing seizures, indicating a significant market opportunity for new treatments [49] - **Pipeline Potential**: Plans to initiate a phase two study in bipolar disorder, leveraging the mechanism of action that targets hyperactivity in the limbic system [50][51] Additional Insights - **Community Engagement**: The trial design was influenced by feedback from the medical community, emphasizing the need for more efficient and predictive drug development methods [21][30] - **Regulatory Perspective**: The FDA is seen as potentially supportive of the innovative trial design, although it remains early in the process [45] This summary encapsulates the key aspects of the conference call, highlighting the company's strategic direction, scientific innovations, and market potential.

Enpro (NPO) FY Conference May 08, 2025 01:30 PM ET Speaker0 Thank you. Good afternoon, everybody. I am Ian Zaffino. I am the equity research analyst covering EnPro. Thank you everybody for joining our industrial conference today. With me from the company will be Joe Broderick and also James Chantille. Joe is the CFO and James is the vice president of investor relations. So with that, guys, thanks for for joining us, and we appreciate you you being here. Speaker1 Pleasure, Ian. Thank you. Speaker0 So I figur ...

Compass Therapeutics (CMPX) 2025 Conference May 08, 2025 01:30 PM ET Speaker0 so we're gonna go ahead and get started on time. Again, welcome to the second day of the Citizens Life Science Conference. It's my pleasure to introduce the next presenting company which is Compass Therapeutics. Presenting for the company or having our discussion is Doctor. Tom Schutz, CEO of Compass. Welcome Tom, really appreciate your time. Speaker1 Thanks, Ren. Thanks for inviting us. Speaker0 So, you know, people in the audien ...

Contango Ore (CTGO) Update / Briefing May 08, 2025 01:00 PM ET Speaker0 Good evening, depending on where in the world you're signing in from. Certainly, a lot of time zones on today's call, so I do appreciate you joining us. I'm on the TangoWorks talk about the recent publishing of the technical report summary on the Johnson Track project with some pretty attractive economics. So I've got on today, CEO, Rick Van Nuneheiser and CFO, Mike Clark, gentlemen. How are you today? Speaker1 Doing well. Romeo, I'm in ...

Senti Biosciences (SNTI) 2025 Conference May 08, 2025 01:00 PM ET Speaker0 Are you ready to kick it off? Yeah. Whenever you guys wanna do. Speaker1 Okay. Welcome back to the Citizens Life Science Conference. My name is Silvan Turca, and I'm a senior analyst covering precision medicines. And now it's my pleasure to introduce Sandi Biosciences. Presenting will be Tim Liu, CEO and cofounder, and Jay Cross, CFO. Thank you so much for coming and joining us today. Speaker0 Well, thanks a lot, Silvan. Appreciate t ...

Modine Manufacturing Company (MOD) FY Conference May 08, 2025 12:45 PM ET Speaker0 Well, good afternoon, everyone, and welcome back to day four of Oppenheimer's twentieth Annual Industrial Growth Conference. I'm Noah Kaye, Managing Director and Equity Research here at OpCo. We're very happy to welcome back the management team of Modine to our conference. Neil Brinker, president CEO, Mick Lucarelli, CFO, Kathy Powers, VP of IR. Thank you all for being here, and looking forward to a great discussion. Well, go ...

Summary of Pharvaris (PHVS) Conference Call - May 08, 2025 Company Overview - **Company**: Pharvaris - **Focus**: Development of treatments for hereditary angioedema (HAE) with a unique mechanism targeting the bradykinin pathway Key Points Industry Context - **Market Dynamics**: The hereditary angioedema treatment market is highly competitive, with a significant focus on prophylactic treatments. Currently, 62% of the U.S. market is prophylactic, with expectations for growth to 70-80% [13][14][46]. Product Differentiation - **Ducritoban**: Pharvaris's lead product, a B2 receptor antagonist, offers two formulations: immediate release for rapid onset and extended release for 24-hour coverage. This positions it uniquely compared to existing plasma kallikrein inhibitors [5][6][10]. - **Patient Coverage**: Ducritoban can potentially treat a broader patient population, including type 3 HAE patients, which are often overlooked by current treatments [6][7]. Efficacy and Safety - **Phase II Results**: Ducritoban demonstrated an 85% reduction in overall attacks and over 92% reduction in moderate to severe attacks in placebo-controlled trials [53]. The drug was well tolerated over two years with no treatment-related signals observed [11]. - **On-Demand Treatment**: The time to symptom relief was approximately 1.1 hours, with complete resolution within 12 hours, showcasing its efficacy compared to existing treatments [20][21]. Phase III Trials - **Ongoing Studies**: The Phase III trial for on-demand treatment is expected to report top-line results in the first half of 2026, with a focus on symptom relief onset and overall attack management [35][69]. - **Prophylaxis Study Design**: The prophylaxis trial will involve a six-month placebo-controlled study with a 2:1 active placebo ratio, targeting 81 patients [55]. Market Opportunities - **On-Demand vs. Prophylactic**: While the on-demand market is smaller (21% of value), there is significant opportunity as 30-40% of attacks go untreated. The introduction of effective oral therapies could change treatment dynamics [46][48]. - **Patient Preferences**: There is a growing preference for oral treatments, with 70% of patients now favoring oral over injectable options, indicating a shift in market dynamics [63][64]. Financial Position - **Cash Reserves**: As of December 2024, Pharvaris had €280 million in cash, providing a strong financial position to support ongoing and future studies [68]. Future Directions - **Acquired Angioedema Study**: Pharvaris plans to initiate a pivotal study for acquired angioedema by the end of 2025, expanding its target population beyond HAE [69][70]. Additional Insights - **Long-Term Safety Confidence**: The company has built confidence in the long-term safety of bradykinin antagonism based on historical data from similar treatments [8][10]. - **Patient Treatment Burden**: The oral formulation reduces treatment burden compared to injectables, which require more complex administration [32][33]. This summary encapsulates the key insights from the Pharvaris conference call, highlighting the company's strategic positioning, product differentiation, and market opportunities within the hereditary angioedema treatment landscape.

Esperion Therapeutics (ESPR) 2025 Conference May 08, 2025 12:30 PM ET Speaker0 I guess take a step back and Primary. I guess take a step back and go go through the data that went into those new labels. Can you just walk us through the clear outcome study and the findings there? Speaker1 So the clear outcome study was a 14,000 patient outcome study which measured MACE four, MACE three in a variety of endpoints in both a, in a non statin population in both a primary and secondary prevention patient population ...

Limbach (LMB) FY Conference May 08, 2025 12:00 PM ET Speaker0 Great. Thank you, everybody. Mike McCann, President and CEO of Limbach Holdings. Joining me on this call today will be Jamie Brooks, EVP and CFO. She'll be available for Q and A. So look forward to getting into the discussion today, a little bit about Limbach Holdings. We reported at the end of the day, Monday, and we'll be talking about our growth strategy and market opportunity. So the first thing, a lot of times we are classified as E and C co ...