Financial Performance - Net income for the second quarter was $15.1 million, a decrease of 14.5% compared to the previous quarter, primarily due to credit loss expense[8, 33] - Preprovision net revenues increased by 3.7%, or $1 million, driven by a 3.7% increase in net interest income and a 4.5% increase in noninterest income[9] - Net interest margin was 3.07%, up from 3.02% in the first quarter[8, 24] - Noninterest expense increased by 4% to $36.3 million, mainly due to a $1.1 million increase in salaries and benefits[43] Loan and Deposit Portfolio - Loan receivables reached $6.31 billion, a slight increase of 0.4% from the end of the first quarter[9] - Deposits totaled $6.73 billion, up 1.7% from the previous quarter, with noninterest-bearing deposits accounting for 31.3% of total deposits[9, 19] - Loan production for the second quarter was $329.6 million, with a weighted average interest rate of 7.10%[9] - The securities portfolio was $994.6 million, representing 13% of assets, with an unrealized loss position of $76.5 million[71] Asset Quality and Capital - Criticized loans decreased significantly by 71.8% to 0.74% of total loans, reflecting $85.3 million in loan upgrades, a $20 million loan payment, and an $8.6 million loan charge-off[9] - Nonaccrual loans fell by 26.8% to 0.41% of total loans, and loan delinquencies declined to 0.17% of total loans[9] - The ratio of tangible common equity to tangible assets was 9.58%, and the common equity tier 1 capital ratio was 12.12%, remaining essentially unchanged from the first quarter[9]

Financial Performance - Q2 Total Revenues were $4.3 billion, a decrease of 1%[15] - Adjusted diluted EPS grew by 2% to $1.87, while reported diluted EPS increased by 7%[14, 15] - Operating Ratio increased by 50 bps to 61.7% compared to adjusted, and increased by 230 bps compared to reported[15] - Year-to-date Free Cash Flow increased by 5% to $1.5 billion[48] Operational Efficiency - RTMs decreased by 1%[14, 15] - Car Velocity increased from 210 to 213 car miles per day[21] - Through Dwell decreased slightly from 6.9 to 6.8 hours[21] - Train delays caused by work blocks decreased by 4% year-to-date 2025 vs year-to-date 2024[26] - GTMS/T&E employee increased by 11% in Q2 2025 vs Q2 2024[30] - Tie installation efficiency increased by 7% in Q2 2025 vs Q2 2024[32] Revenue Breakdown - Overall carloads remained flat[36] - Grain & Fertilizers revenue increased by 12%, while Automotive, Forest products, Metals & Minerals, and Petroleum & Chemicals decreased by 6%, 9%, 7%, and 6% respectively[36] Outlook - The company now assumes low single-digit RTM growth for the year[43] - The company expects mid to high single-digit adjusted diluted EPS growth[58]

ABTECT Phase 3 Program Overview - The ABTECT Phase 3 program included 2 induction trials (ABX464-105, ABX464-106) and 1 maintenance trial (ABX464-107) [25] - The trials enrolled 1,275 patients across 36 countries [20, 60] - The trials included both advanced therapy naïve (52.7%) and refractory patients (47.3%) [60] Efficacy Results - In ABTECT 1 (Study 105), the 50mg dose of obefazimod achieved a clinical remission rate of 21.7%, a 19.3% difference compared to placebo (2.5%) (p<0.0001) [33, 60] - In ABTECT 2 (Study 106), the 50mg dose of obefazimod achieved a clinical remission rate of 19.8%, a 13.4% difference compared to placebo (6.3%) (p=0.0001) [40, 60] - Pooled analysis of ABTECT 1 & 2 showed a clinical remission rate of 20.8% with 50mg obefazimod, a 16.4% difference compared to placebo (4.4%) (p<0.0001) [47, 60] - In ABTECT 1, the 25mg dose of obefazimod achieved statistically significant results on all key secondary endpoints [36] - In ABTECT 2, the 50mg dose of obefazimod achieved statistical significance on all key secondary endpoints [43] Safety and Tolerability - Obefazimod was generally well tolerated with no new safety signals observed in Phase 3 induction trials [20, 60] - In ABTECT 1, Any TEAE was 46.9% for Obe 25 mg, 59.4% for Obe 50 mg, and 53.2% for Placebo [52] - In ABTECT 2, Any TEAE was 50.9% for Obe 25 mg, 61.0% for Obe 50 mg, and 48.4% for Placebo [52] Next Steps - 44-week maintenance data is expected in Q2 2026 [25, 60]

Company Overview - Cal-Maine Foods is the 1 U S producer and distributor of fresh eggs [7] - The company's mission is to be the most sustainable producer and reliable supplier of fresh eggs, egg products, and prepared foods in the United States [10, 126] - Cal-Maine Foods operates with a fully integrated operation, processing approximately 81 million eggs per hour [22, 23] - Cal-Maine Foods has acquired 26 companies through July 22, 2025 [43, 46] Financial Performance and Strategy - Cal-Maine Foods' financial strategy prioritizes operational efficiency, a strong balance sheet, and disciplined capital allocation [30] - The company has a variable dividend policy, allocating one-third (1/3) of net income to shareholders [40, 140] - Cal-Maine Foods has paid over $796 million in total dividends as of FY25 [40] - The company's average dividends declared or paid for FY2025 is $326 per share [40] - Cal-Maine Foods' adjusted EBITDA margin for FY25 is 400% [136] Market Dynamics and Growth - 97% of U S households purchase eggs [12] - Cal-Maine Foods' largest customer accounts for 34% of revenue as of FY25 [81] - Approximately 27% of U S households are expected to be in states with cage-free mandates by 2030 [102]

Financial Performance - Net income for Q2 2025 was $93 million[8] - Diluted earnings per share (EPS) reached $052[8] - Net interest margin (NIM) expanded to 292%[8] - Return on average tangible common equity was 850%[8] Balance Sheet & Loan Portfolio - Gross loans held for investment (HFI) increased to $323 billion[8] - Total deposits amounted to $319 billion[8] - Annualized loan growth was 12%[9, 13] - Loans HFI increased by $916 million[13] Asset Quality - Nonperforming loans (NPLs) decreased by $36 million or 6%[9] - NPLs/Total Loans ratio was 176%[8] - Nonperforming assets (NPAs) decreased to $610 million[8] Capital & Efficiency - Common Equity Tier 1 (CET1) Ratio was 1761%[8] - Tangible common equity (TCE) ratio was 1107%[8] - Efficiency ratio improved to 5722%[8] Deposits - Deposits increased by $456 million or 6% annualized[13] - Uninsured deposits totaled $15 billion, representing 478% of total deposits[50]

Financial Performance - Net income for Q2 2025 was $140 million, or $2.19 per diluted share[11], compared to $119.8 million, or $1.86 per diluted share in Q1 2025[11, 14] - Net interest income increased by $11.9 million sequentially to $328.2 million[37, 39] - Total fees and commissions were $197.3 million, a 7.2% decrease year-over-year[34] - The efficiency ratio was 65.4% in Q2 2025, compared to 68.3% in Q1 2025[11] Balance Sheet - Period end loans grew by $602 million, or 2.5%, to $24.3 billion[14, 15] - Period end deposits decreased slightly by 0.1% to $38.2 billion[15] - Assets under management or administration increased by $3.9 billion to $117.9 billion[16] Asset Quality - Non-performing assets, excluding government guaranteed loans, were $74 million, representing 0.31% of outstanding loans and repossessed assets[14, 27] - Net charge-offs were $561 thousand during Q2[14, 27] - The allowance for credit losses was $330 million, or 1.36% of loans at quarter end[27] Outlook - The company expects mid to upper single-digit loan growth for the full year 2025[47] - Net interest income is projected to be between $1.325 billion and $1.375 billion for 2025, assuming two 25 basis point rate cuts[47]

Financial Performance - GAAP net loss for 2Q25 was $(27.9) million, or $(0.22) per diluted share[4], while net income excluding notable items was $24.5 million, or $0.19 per diluted share[4] - Net interest income before provision for credit losses increased by 17% QoQ to $117.53 million[64] - Noninterest income totaled $(23) million, including a net loss of $39 million from legacy securities AFS repositioning[48]; excluding notable items, noninterest income was $16 million, up 1% QoQ and 44% YoY[48] - GAAP noninterest expense was $109 million, including merger-related costs[52]; excluding notable items, noninterest expense was $92 million, up 13% QoQ[52] Balance Sheet & Capital - Total deposits reached $15.9 billion at 6/30/25, up 10% QoQ, largely due to the Territorial acquisition[5, 18] - Loans receivable totaled $14.4 billion at 6/30/25, up 8% QoQ, also largely reflecting the Territorial acquisition[5, 21] - Total capital ratio was 13.76% at 6/30/25[5] - Tangible common equity (TCE) ratio was 9.43% at 6/30/25[5] Asset Quality - Nonperforming assets (NPA) were $113 million, or 0.61% of total assets at 6/30/25[5] - Criticized loans decreased by 8% QoQ to 2.87% of total loans[5] - Net charge-offs (NCO) were $12 million in 2Q25, or 33bps of average loans, annualized[59] Strategic Initiatives - The acquisition of Territorial Bancorp Inc added $1.7 billion of stable, low-cost deposits and $1.0 billion of residential mortgage loans[5] - Repositioned $418 million of legacy investment securities available-for-sale (AFS) in June 2025, expected to contribute approximately $12 million to interest income annually[5, 36] Outlook - The company anticipates high single-digit % growth for end-of-period loans in 2025[60] - The company anticipates high single-digit % growth for net interest income in 2025[60] - The company anticipates upper-20s % growth for noninterest income (excluding notable items) in 2025[60]

July 2025 Page 1 Disclosure Regarding Forward-Looking Statements This presentation may contain statements that are forward looking. These statements are based on current expectations and assumptions that are subject to risks and uncertainties, which may cause actual results to differ materially. A summary of risks and uncertainties is described in more detail in our periodic reports filed with the Securities and Exchange Commission (SEC). We undertake no duty to update or revise this presentation, whether a ...

Financial Highlights - Total assets reached $35 billion as of June 30, 2025[10] - Total loans amounted to $28 billion[10] - Total deposits were $29 billion[10] - Net interest margin (NIM) increased to 404% in Q2 2025[14] - Return on average assets (ROA) was 131% in Q2 2025[14] Loan Portfolio - Total loans reached $28 billion with a YTD annualized growth rate of 3%[30] - Houston market experienced an 18% annualized growth rate YTD[30] - Commercial Real Estate Owner Occupied (CRE OOO) loans constitute 26% of the total loan portfolio[29] - Commercial & Industrial (C&I) loans make up 153% of the total loans[41] Deposits - Total deposits reached $2908234 thousand in Q2 2025[71] - Non-interest bearing deposits represent 27% of the total deposit composition[72] - The annualized deposit growth rate for 2025 is 9%[72]

Financial Performance Highlights - Net income for the first six months of 2025 reached a record of $384.6 million, an increase of $44.9 million or 13% compared to the same period in 2024[10] - Diluted earnings per share (EPS) for the first six months of 2025 were $5.47, up $0.26 or 5% from the same period in 2024[10] - Net interest income for the first six months of 2025 was $1.1 billion, an increase of $138.4 million or 15% compared to the same period in 2024[10] - Total assets reached $69.0 billion, an increase of $9.2 billion or 15% compared to June 2024[10, 16] - Total loans amounted to $51.0 billion, an increase of $6.3 billion or 14% compared to June 2024[10, 16] - Total deposits increased to $55.8 billion, an increase of $7.8 billion or 16% compared to June 2024[10, 16] Balance Sheet and Capital - Tangible book value per common share (non-GAAP) increased to $81.86 as of June 30, 2025[10, 14] - The investment portfolio totaled $8.7 billion as of June 30, 2025, representing 13% of total assets[41] Credit Quality - Non-performing loans totaled $189 million, comprising 0.37% of total loans as of June 30, 2025[16]