This document contains forward-looking statements concerning Eton Pharmaceuticals, Inc. ("Eton", the "Company," "we," "us," and "our"). The words "believe," "may," "will," "potentially," "estimate," "continue," "anticipate," "intend," "could," "would," "project," "plan," "expect" and similar expressions that convey uncertainty of future events or outcomes are intended to identify forward-looking statements. These forward-looking statements include, but are not limited to, statements concerning the following ...

Unleashing the Potential of Immuno-Oncology Therapies June 5, 2025 © 2025 Xilio Therapeutics, Inc. 1 Forward-Looking Statements and Disclaimers This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, statements regarding plans, timing and expectations related to: development timelines and anticipated milestones for Xilio's programs; the receipt of future contingent payments under Xilio's coll ...

NGN-401 for Rett Syndrome - NGN-401, a gene therapy leveraging EXACT transgene regulation technology, is being developed for Rett syndrome [15] - Rett syndrome affects an estimated 6,000-9,000 patients in the U S [20] - The worldwide incidence of Rett syndrome is estimated at 1 in 10,000 females [20] - Phase 1/2 data showed durable improvements, including a two-point improvement in CGI-I in all participants [38] - All four participants in the Phase 1/2 trial achieved a CGI-I rating of "Much Improved" [41] - The company expects to announce additional Phase 1/2 clinical data in the second half of 2025 [64] Clinical Trial and Regulatory Updates - The FDA has accepted the conversion of the Phase 1/2 trial to a registrational trial for NGN-401 [28] - The Embolden registrational trial is designed as an open-label, single-arm, baseline-controlled study [27] - The proposed number of participants in the Embolden trial is 18, subject to FDA feedback [28] - The company anticipates providing a regulatory update regarding the registrational trial in the first half of 2025 [64] Manufacturing and Financials - Neurogene has a 42,000 sq ft in-house AAV manufacturing facility in Houston, with 6,000 sq ft of cleanrooms [11] - The company's cash runway is expected to fund operations into early 2028 [6, 64]

Company Performance Highlights - Caesars Digital generated over $1.2 billion of TTM Net Revenue and $155 million of Adjusted EBITDA [19] - Caesars Digital's Q1 '25 TTM Net Revenue is 20% above Q1 '24 TTM [19] - Caesars Digital's Q1 '25 TTM Adjusted EBITDA is 230% above Q1 '24 TTM [19] - Las Vegas properties generated over $1.0 billion of TTM Adjusted EBITDAR [30] - Regional properties' capital spend comprises approximately 65% of Q1 2025 Regional segment Adjusted EBITDAR [33] - Caesars Digital's iGaming net gaming revenue increased by 53% YoY in Q1 2025 to $118 million [56, 59] Financial Outlook - The company anticipates $1.35 billion in master lease rent [41] - The company's current weighted average cost of debt is 6.5%, implying $775 million of full-year interest expense [41] - The company projects mid-point capital expenditures of $606 million for 2025, excluding Caesars Virginia JV [41] - The company estimates cash income taxes at approximately 5% of Adjusted EBITDAR [41]

Financial Data and Key Metrics Changes - Revenue for the third quarter was $67.1 million, down 9% year-over-year and 4% year-to-date, but up 13% sequentially [29] - Adjusted EBITDA was $7.3 million, exceeding expectations and higher than the top end of the guidance range of $4 million to $6.5 million [6][33] - Operating expenses increased to $53.5 million, primarily due to restructuring charges and increased selling, general, and administrative expenses [30] Business Line Data and Key Metrics Changes - The Enterprise Division generated 70% of total revenue, with revenue of $47.3 million, down from $51.9 million in the prior year [34] - The Education Division's revenue was $18.6 million, down 8% compared to the prior year, but subscription revenue grew 13% [39] - Adjusted EBITDA for the Education Division decreased to $2.1 million from $3.1 million last year due to lower revenue [39] Market Data and Key Metrics Changes - North America segment revenue was $37.1 million, a decrease of $3.5 million from the prior year, with subscription and subscription services revenue down 4% year-to-date [35] - International direct operations revenue was $7.5 million, a decrease of $1 million, primarily due to challenging business conditions in Asia and the UK [36] - The balance of billed deferred subscription revenue in North America was $45 million, down from $47.2 million in the prior year [36] Company Strategy and Development Direction - The company is focused on cost reductions while maintaining investments in growth initiatives, particularly in the Enterprise North America business [6][32] - A new Chief Marketing Officer has been appointed to accelerate marketing efforts and penetrate the total addressable market [22] - The company expects to grow its education business year-over-year despite uncertainties, with strong demand for its "Leader in Me" program [25][39] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the company's ability to navigate economic uncertainties and continue winning large deals [8][46] - The revised revenue guidance for the fiscal year is now between $265 million and $275 million, reflecting ongoing uncertainties and timing risks [9][42] - Management anticipates a meaningful increase in adjusted EBITDA and free cash flow in fiscal year 2026 due to cost reduction actions [43] Other Important Information - The company has completed cost reduction initiatives that are expected to yield annualized savings of $8 million in fiscal year 2026 [32] - The percentage of clients in multi-year contracts increased from 55% to 58%, indicating a strong client retention strategy [21] Q&A Session Summary Question: Can you share milestones regarding the enterprise division's performance? - Management highlighted the increase in new logos and expansion within existing clients, emphasizing the separation of sales teams for better focus [51][53] Question: What are the expectations for new school additions in the education division? - Management expects to meet or exceed the previous year's new school additions, citing the effectiveness of the "Leader in Me" solution [62][63] Question: Can you break down the guidance reduction by segment? - The reduction primarily stems from timing issues in service delivery and ongoing uncertainties affecting enterprise clients [65][68] Question: How does the company foresee the current environment impacting fiscal year 2026? - Management is planning for continued scrutiny of budgets and tariffs, but remains committed to navigating through these challenges [74][75] Question: What is the current adoption rate of AI service delivery? - Approximately 43% of clients are using the AI sales coach, with expectations for increased adoption as the technology evolves [85]

Financial Data and Key Metrics Changes - Revenue for Q3 2025 was $67.1 million, down 9% year-over-year and 4% year-to-date, but up 13% sequentially [27] - Adjusted EBITDA was $7.3 million, exceeding expectations and down from $13.9 million in the prior year [30][31] - Gross margin remained strong at approximately 76.5% of revenue, flat year-over-year [27] - Operating expenses increased to $53.5 million, primarily due to restructuring charges and increased selling, general, and administrative expenses [28] Business Line Data and Key Metrics Changes - The Enterprise Division generated 70% of total revenue, with Q3 revenue at $47.3 million, down from $51.9 million in the prior year [32] - The Education Division's revenue was $18.6 million, down 8% year-over-year but grew 1% year-to-date [36] - Subscription revenue in the Education Division increased by 13% to $11.8 million [36] Market Data and Key Metrics Changes - The North America segment revenue was $37.1 million, a decrease of $3.5 million from the prior year, affected by government actions [33] - International direct operations revenue was $7.5 million, down $1 million due to challenging business conditions [34] - The number of multi-year contracts in North America increased from 55% to 58% [34] Company Strategy and Development Direction - The company is focused on cost reductions while maintaining investments in growth initiatives [5][6] - A new Chief Marketing Officer has been appointed to accelerate marketing efforts and penetrate the total addressable market [21] - The company expects to grow its education business year-over-year despite uncertainties [22] Management's Comments on Operating Environment and Future Outlook - Management acknowledged the uncertain external environment affecting investment decisions and cost scrutiny [5] - Revised revenue guidance for the fiscal year is now between $265 million and $275 million, with adjusted EBITDA guidance widened to $28 million to $33 million [7][40] - Confidence remains in the fundamental strengths of the business and the potential for future growth [7] Other Important Information - The company has completed cost reduction initiatives that are expected to yield significant savings in the coming fiscal year [6][29] - Deferred subscription revenue increased by 7% year-over-year, indicating a strong foundation for future growth [31] Q&A Session Summary Question: Can you share milestones regarding the enterprise division's performance? - Management noted improvements in new logo sales and expansion within existing clients, with a focus on off-cycle expansion opportunities [50][52] Question: What are the expectations for new school additions in the education division? - Management expects to meet or exceed the previous year's new school additions, citing strong demand for their solutions [60][61] Question: Can you break down the guidance reduction by segment? - The reduction primarily stems from timing issues in service delivery and ongoing uncertainty affecting enterprise clients [63][66] Question: How do you foresee the current environment impacting fiscal 2026? - Management is planning for continued scrutiny of budgets and uncertainty in the enterprise level due to tariffs and other factors [70][71] Question: What is the current status of deferred revenue growth relative to total revenue growth? - Management explained that deferred revenue growth is driven by invoiced amounts from prior years, and they expect future growth to translate into reported revenue [73][78] Question: What is the adoption rate of AI service delivery among clients? - Approximately 43% of clients are using the AI sales coach, with expectations for continued growth in this area [81]

Snowflake (SNOW) FY 2025 Annual General Meeting July 02, 2025 12:00 PM ET Speaker0 Twenty twenty five Annual Meeting of Stockholders. I would like to introduce our presenter, Mr. Sreedhar Ramaswamy, Snowflake's Chief Executive Officer and the Chairperson of today's meeting. Mr. Ramaswamy, I'll turn the meeting over to you. Speaker1 Thank you. The meeting will now officially come to order. The time is now 9AM Pacific on Wednesday, 07/02/2025, Speaker2 and the polls are open for voting on all matters to be pr ...

Financial Performance and Outlook - Ligand reported $311 million in cash and investments as of March 31, 2024 [5] - The company projects long-term royalty revenue CAGR of >20% and EPS CAGR of >25% [5, 8] - 2024 financial guidance includes royalty revenue of $90 million - $95 million, representing 16% growth over 2023 [9] - Core adjusted diluted EPS for 2024 is projected at $4.25 - $4.75, a 17% increase over 2023 [9] - Total revenue for 2024 is guided at $130 million - $142 million, including Captisol revenue of $25 million – $27 million and contract revenue of $15 million - $20 million [9] Royalty Portfolio and Pipeline - Ligand has 8 major commercial-stage royalty streams and over 80 additional active programs with economic rights [5] - Kyprolis reported $376 million in Q1 2024 sales and is projected to exceed $1.5 billion in total 2024 global sales [28] - Filspari reported $19.8 million in Q1 2024 sales and has the potential to be Ligand's largest royalty stream [28] - Vaxneuvance reported $219 million in Q1 2024 sales [28] - Rylaze reported $103 million in Q1 2024 sales [28]

Financial Performance and Guidance - Ligand's total revenue guidance for 2024 is $160-$165 million[21], with royalty revenue expected to be $105-108 million[22], representing a 27% increase from 2023[30] - The company anticipates adjusted EPS of $550-$570 in 2024[22], a 38% growth[30] - For 2025, Ligand forecasts total revenue of $180-$200 million[34], with royalty revenue growing by 30% over 2024[35] - Ligand projects royalty receipts to grow at a CAGR of 22% from 2024 to 2029[24, 40] Investment and Portfolio Activity - Ligand deployed $192 million across 8 different investments in 2024[21] - The company's Q4 pipeline includes over 30 actionable opportunities, representing over $1 billion of potential investments[61] - Ligand acquired Apeiron Biologics in July 2024 for approximately $100 million, gaining rights to Qarziba royalties[70] Key Products and Platforms - Ligand's Captisol platform is used in 16 approved products[99, 104] - Verona's Ohtuvayre, in which Ligand has royalty rights, achieved over $11 million in sales in the first 4 months following approval[75] - Travere's Filspari generated $356 million in Q3 2024, with 31% growth from Q2 2024[80] - Merck's Capvaxive, another royalty asset for Ligand, protects against strains that cause 84% of invasive pneumococcal disease[88]

Financial Data and Key Metrics Changes - The company affirmed its full-year beer revenue growth outlook despite industry weakness observed in May and June, indicating confidence in achieving guidance [10][12] - The first quarter was described as normal, with a depletion decline similar to the previous quarter, and the company expects sequential improvement as it moves into easier comparisons [11][12] - The impact of incremental tariffs is projected to be around $20 million, with a 20 basis point hit to margins, but the company believes it can still deliver margins in line with previous guidance [14] Business Line Data and Key Metrics Changes - The company is focused on maintaining strong brand health metrics and loyalty among consumers, particularly within the Hispanic demographic, which constitutes a significant portion of its business [19][20] - Marketing investments were higher in Q1 due to seasonality, with a focus on high-impact events to strengthen brand presence [27][28] - The introduction of new products like SunBrew and adjustments in pricing strategies are aimed at capturing market share in the high-end light beer segment [33][57] Market Data and Key Metrics Changes - The company reported high single-digit share gains in the market, indicating a positive trend in brand performance despite overall market challenges [21][52] - The competitive landscape has intensified, with increased marketing activities from competitors, particularly in the high-end light beer category [25][57] - The company is seeing a consistent percentage of alcohol in consumer baskets, despite overall basket sizes shrinking due to economic concerns [20] Company Strategy and Development Direction - The company is committed to controlling its controllables, focusing on distribution and price pack architecture to adapt to consumer spending behaviors [52][54] - There is an ongoing emphasis on innovation, with new product introductions expected to contribute significantly to growth [33] - The company is exploring opportunities for diversification in its portfolio, particularly in the non-alcoholic sector, which has gained traction since the last investor day [32] Management's Comments on Operating Environment and Future Outlook - Management acknowledged macroeconomic uncertainties, including inflation and unemployment, but expressed confidence in the brand's resilience and consumer loyalty [12][13] - The company anticipates a return to more normal consumer behavior as socioeconomic conditions improve, particularly for its Hispanic consumer base [40][41] - The rebuilding efforts following California wildfires are expected to provide a long-term tailwind, although short-term challenges remain due to macroeconomic factors [61][63] Other Important Information - The company has implemented a robust hedging policy to manage currency and commodity risks, particularly concerning the peso [47][49] - The management highlighted the importance of maintaining strong relationships with consumers and adapting to their changing needs in the current economic climate [20][54] Q&A Session Summary Question: Confidence in beer revenue growth outlook and margin guidance - Management confirmed confidence in the unchanged full-year beer revenue growth outlook, noting that the quarter was as expected despite consumer concerns [10][12] Question: Impact of socioeconomic factors on consumer behavior - Management indicated that while occasions for beer consumption have decreased, interest in beer remains strong among consumers, suggesting a potential return to normalcy [40][41] Question: Marketing strategy and competitive landscape - Management discussed increased marketing investments and the competitive landscape, emphasizing the strength of their brands and loyalty among consumers [25][27] Question: Pricing environment in beer - Management acknowledged additional price promotions in the market and indicated adjustments in their pricing strategy to capture share in the high-end light beer segment [57] Question: Rebuilding after California wildfires - Management noted that rebuilding efforts would create job opportunities and potentially boost beer consumption, with this upside factored into their guidance [61][63]